Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.

Iontophoresis, a minimally-invasive methodology that uses a weak electric current to enhance penetration of ionized molecules into tissues, was found to be an effective technique for the intraocular delivery of large bioactive molecules, specifically lutein.

Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.

A conductive gel composition for use with a TTField-generating system is disclosed. Also disclosed are kits containing the gel composition and methods of producing and using the gel composition. The composition includes a semi-solid conductive gel for application to a patient's skin and for placement between the patient's skin and at least one transducer array that generates an alternating electric field having a frequency in a range of from about 50 kHz to about 500 kHz, wherein the conductive gel comprises a free salt present at a concentration in a range of from about 0.1 mM to about 1 M.

A skin treatment device includes a substrate and a plurality of discrete galvanic couples provided on the substrate, each discrete galvanic couple including a first conductive electrode that is an anode and a second conductive electrode that is a cathode, wherein the anode of each galvanic couple includes a first metal and the cathode of each discrete galvanic couple includes a second metal, different from the first metal, the first and second metal having a different standard potential.

The present invention provides a container having an application part, which comprises a composition holding part and a composition application part, wherein the application part is equipped with two or more rotating bodies, and as the material of the rotating bodies, a metal is selected that forms a potential difference due to an ionization phenomenon of a liquid at a part being used and/or the composition contained in the holding part.

A method of reducing or eliminating vertigo symptoms in an individual experiencing vertigo or an individual identified as being susceptible to vertigo is disclosed. The method includes positioning a non-invasive nerve stimulation device on the individual's wrist, wherein the electrodes of the non-invasive nerve stimulation device are in electrically conductive contact with skin at acupuncture point P6 of the wrist. The methods also include generating a stimulation signal and delivering the stimulation signal to the acupuncture point P6 of the wrist to prevent, reduce or eliminate one or more vertigo symptoms in the individual. The vertigo symptoms may include a feeling of spinning, tilting, swaying, or being unbalanced or pulled to one direction, vomiting, abnormal or jerking eye movements (nystagmus), headache, sweating, ringing in the ears, hearing loss, visual disturbances, weakness, difficulty speaking, a decreased level of consciousness, and difficulty walking.

A method of reducing or eliminating alcohol hangover symptoms in an individual identified as experiencing an alcohol hangover is disclosed. The method includes positioning a non-invasive nerve stimulation device on the individual's wrist, wherein the electrodes of the non-invasive nerve stimulation device are in electrically conductive contact with skin at acupuncture point P6 of the wrist. The method also includes generating a stimulation signal and delivering the stimulation signal to the acupuncture point P6 of the wrist to reduce or eliminate one or more alcohol hangover symptoms in the individual. The alcohol hangover symptoms could include headache, nausea, retching, vomiting, fatigue, gastrointestinal distress, drowsiness/lethargy, problems concentrating, dry mouth, and dizziness.

Iontophoresis, a minimally-invasive methodology that uses a weak electric current to enhance penetration of ionized molecules into tissues, was found to be an effective technique for the intraocular delivery of large bioactive molecules, specifically lutein.

Provided is an iontophoresis device. An iontophoresis device according to an embodiment of the present invention includes a power supply unit configured to supply power; two electrodes configured to supply current to a user's skin when brought into contact with the skin, thereby allowing an ionic drug or an active ingredient applied to the user's skin to permeate the skin by an electrical repulsive force; and a control unit configured to adjust an output value of a voltage or a current applied to the electrodes according to the user's skin condition, thereby allowing the user to feel a uniform intensity of electrical stimulation.