The present disclosure relates to implantable capsules for stimulation. One implantable capsule includes a tubular body and a distal member provided at its distal end with an anchoring device adapted to penetrate into a tissue of a wall of an organ of a patient and a distal electrode, the body accommodating a set of functional elements of the capsule and including a proximal electrode. The capsule includes an electrically insulating member between the body and the distal member to isolate the distal member of said body.

Delivery of implantable active agent delivery components includes implanting a distal lead end of a lead into tissue at an implantation site. A delivery stylet is then inserted through a lead lumen of the lead. The delivery stylet includes a stylet body having a distal stylet end and an active agent delivery component detachably coupled to the distal stylet end. The active agent delivery component is inserted into the tissue at the implantation site by extending the distal stylet end of the delivery stylet from a distal lead end of the lead such that the active agent delivery component is inserted into the tissue at the implantation site. The active agent delivery component is then detached within the tissue at the implantation site and the delivery stylet may be retracted and removed from the lead lumen.

A leadless biostimulator has a housing including an electronics compartment, an electronics assembly mounted in the electronics compartment, a proximal electrode that disposed on and/or integrated into the housing, and an electrical feedthrough assembly. The electrical feedthrough assembly includes a distal electrode and a flange. The flange is mounted on the housing. The distal electrode is electrically isolated from the flange by an insulator and configured to be placed in contact with target tissue to which a pacing impulse is to be transmitted by the leadless biostimulator. A mount is mounted on the flange and thereby mounted on the electrical feedthrough assembly. A fixation element is mounted on the mount and configured to facilitate fixation of the leadless biostimulator to tissue of a patient.

A shaft of an interventional medical system catheter has a distal end formed by opposing elastically deformable retention features that protrude into a lumen of the shaft, and that define an expandable distal opening of the lumen. The retention features secure an implantable medical device to the catheter by an interlocking engagement within a gap defined by a necked-in portion of a device holding member. Each retention feature includes a distal-facing surface defining the distal opening, and, when an elongate release member of the catheter, which extends within the shaft lumen, applies a push force against proximal-facing surfaces of the features, the distal opening expands from a constricted to an open configuration, wherein the open configuration allows passage of the device holding member through the distal opening, and the constricted configuration allows for the interlocking engagement with the device.

Embodiments of the present invention provide an electroporation system comprising an electroporation probe having at least two contiguous electrodes configured to be inserted into biological tissue for electroporation treatment, and a pulse generator electrically connected to the probe and configured to drive the electroporation probe using a sequence of one or more electric pulses to cause current transmission through the probe and induce a non-uniform electric field in the biological tissue proximate the probe electrodes. Treatment tissue can be targeted by controlling the probe configuration, carrier solution characteristics and parameters of the electroporation pulse sequence to achieve predictable electroporation outcomes. This electroporation control method can also reduce potentially toxic effects of electroporation treatment.

A leadless biostimulator includes a housing, and distal and proximal electrodes disposed on or integrated into the housing. The distal electrode includes an electrode body and an electrode tip mounted on a distal end of the electrode body, wherein the electrode tip is electrically conductive and configured to be placed in contact with a stimulation site. The electrode tip includes a distal tip end facing a surrounding environment and opposite a proximal tip end. The electrode tip defines a tip hole extending through the electrode tip along a longitudinal axis of the housing from the distal tip end to the proximal tip end. The tip hole comprises a through hole having a first diameter at the distal tip end and a second diameter at the proximal tip end of the tip electrode, wherein the first diameter of the tip hole is less than the second diameter of the tip hole.

The present disclosure relates to implantable capsules for stimulation. One implantable capsule includes a tubular body and a distal member provided at its distal end with an anchoring device adapted to penetrate into a tissue of a wall of an organ of a patient and a distal electrode, the body accommodating a set of functional elements of the capsule and including a proximal electrode. The capsule includes an electrically insulating member between the body and the distal member to isolate the distal member of said body.

A shaft of an interventional medical system catheter has a distal end formed by opposing elastically deformable retention features that protrude into a lumen of the shaft, and that define an expandable distal opening of the lumen. The retention features secure an implantable medical device to the catheter by an interlocking engagement within a gap defined by a necked-in portion of a device holding member. Each retention feature includes a distal-facing surface defining the distal opening, and, when an elongate release member of the catheter, which extends within the shaft lumen, applies a push force against proximal-facing surfaces of the features, the distal opening expands from a constricted to an open configuration, wherein the open configuration allows passage of the device holding member through the distal opening, and the constricted configuration allows for the interlocking engagement with the device.

In general all embodiments relate to implantable medical devices including at least one injectable device and at least one anchor for fixation of the injectable device to body tissue. The anchor of the implantable medical device fulfills the requirement for secure anchoring of the injectable device to body tissue. The medical device includes at least one contrast agent reservoir with an outlet, wherein the reservoir is filled with a contrast agent, which may be released through the outlet into body tissue or cavities. The contrast agent is able to be visible with known imaging methods comprising X-ray or Mill imaging or other well-known techniques to determine if a secure anchoring of the medical has been achieved.

Techniques for delivering genetic material to a target tissue site of a patient via a leadless implantable medical device that includes a pump and a stimulation energy delivery element are described. In some examples, delivery of genetic material to the target tissue site causes transgene expression of tissue at the target tissue site, which may result in generation of new cells or modified properties of existing cells of the target tissue site, facilitating more effective and efficient treatment of a disorder of the patient.