The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting pain while preserving other sensory and motor function, and proprioception.

A device for treating sleep disordered breathing includes a stimulation element to stimulate an airway-patency-related nerve.

A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

Disclosed herein are systems and methods for nerve conduction block that can involve the delivery of relatively high amounts of charge safely to tissue. Such systems and methods can include control systems for safely monitoring a direct current electrode system, including delivering direct current via an electrode lead to a target tissue of a patient; measuring the driving voltage across the electrode; comparing the driving voltage across the electrode to predetermined threshold range values; measuring the body impedance; determining a voltage drop across the lead from the body impedance measurement; and adjusting the driving voltage to maintain the voltage drop across the lead within a predetermined voltage range.

Methods and systems are described for detecting if a stimulation lead implanted in a patient's brain has moved. Lead movement occurring between a first time and a second time may be determined by comparing features extracted from evoked potentials recorded at the two times. The disclosed methods and systems are particularly useful for determining if a stimulation lead has moved between the time it was implanted in the patient's brain and the time that stimulation parameters are being optimized. Lead movement during implantation, during parameter optimization, and during or between other lead optimization processes may be determined as well.

Processing circuitry of a system configured to determine a patient state based on sensed signals including posture and activity information and control delivery of electrical stimulation therapy to the patient via electrodes implanted proximal to target tissue of the patient. The sensed signals also include impedance measurement, and other bioelectrical signals, where sensing is interleaved with the electrical stimulation therapy. Responsive to determining the patient state, select an action, wherein the selected action comprises one or more of: store collected information, upload the collected information to an external computing device, and output an electronic signal comprising an alert.

Processing circuitry for a medical system configured to determine posture and activity information of a patient and sense bioelectrical signals as well as receive information about the environment of the patient. The processing circuitry is configured to determine respiration activity of the patient based on the sensed signals and determine a degree of distress of the patient based on the sensed signals and the determined respiration activity. Responsive to determining the degree of distress, the processing circuitry is configured to output a command signal, which may adjust the output of stimulation circuitry configured to deliver electrical stimulation to a patient via a set of electrodes implanted proximal target tissue of the patient, upload the received information, cause the communication circuitry to send an electronic message comprising a notification of the degree of distress of the patient or take other actions.

Processing circuitry for a medical system configured to sense bioelectrical signals and determine posture and activity information as well as information about the environment of the patient. The processing circuitry is also configured to control stimulation generation circuitry to deliver the electrical stimulation therapy, and interleaved with the electrical stimulation therapy, control the stimulation generation circuitry to output an impedance measurement signal. The processing circuitry is further configured to determine respiration of the patient based on the impedance. Responsive to determining the respiration of the patient, the processing circuitry may then determine a patient state based on the determined respiration, and the posture and activity information of the patient. Based on the patient state, the processing circuitry may select an action including one or more of: store collected information, upload the collected information to an external computing device, and output an electronic signal comprising an alert.

A biocompatible soft pressure sensor comprises: a stretchable top electrode comprising a first elastomeric substrate and a first biocompatible conducting polymer coated on an inner surface of the first elastomeric substrate; a stretchable bottom electrode comprising a second elastomeric substrate including a textured inner surface comprising an array of peaked structures, and a second biocompatible conducting polymer coated on the textured inner surface, where a coated tip of each peaked structure is in contact with the first biocompatible conducting polymer; a top encapsulation layer on an outer surface of the first elastomeric substrate; and a bottom encapsulation layer on an outer surface of the second elastomeric substrate. A resistance measured by the biocompatible soft pressure sensor changes upon exposure to an external pressure.

An example implanted medical device includes one or more vestibular sensors and one or more cochlear sensors. Data obtained from the one or more vestibular sensors are used to diagnose or predict a condition of the cochlear system. Data obtained from the one or more cochlear sensors are used to diagnose or predict a condition of the vestibular system. Treatment actions can be performed based on the diagnosis or prediction.