A device for treating sleep disordered breathing includes a stimulation element to stimulate an airway-patency-related nerve.

Methods and systems for improving headache pain by using feedback mechanisms are provided.

A device for treating sleep disordered breathing includes a stimulation element to stimulate an airway-patency-related nerve.

A neuromodulation system and method with feedback optimized electrical field generation for stimulating target tissue of a patient to treat neurological and non-neurological conditions. The system generally includes implantable electrodes, implantable sensors, an implantable or external electrical signal generator, and an implantable or external controller. The controller controls the electrical signal generator to generate electrical noise stimulation signals that are delivered to the target tissue via the electrodes and that produce an optimized electric field having maximized voltage with low current density. The sensors produce temperature and impedance data for the target tissue and the controller automatically responds to values of the sensor data that indicate potential damage to the target tissue to reduce the strength of the electric field.

Systems, devices, and methods for delivering one or more electrical pulses to a target region within a patient's body are disclosed herein. An implantable neurostimulator for delivering such one or more electrical pulses can include a hermetic housing made of a biocompatible material, an energy storage feature, and at least one lead. The implantable neurostimulator can further include stimulation circuitry that can include a first circuit and a second circuit. The first circuit can include an adjustable resistance element having a first terminal and a second terminal, a first switch coupled to the first terminal of the adjustable resistance element and selectively coupleable with a stimulation-voltage node and a ground node, a second switch selectively coupling the a first one of the plurality of electrodes to one of: the second terminal of the adjustable resistance element; and the stimulation-voltage node.

Example neurostimulation induced medicine devices and methods of use are described herein. An example endotracheal device can include an elongate tubular member having a proximal end and a distal end, an inflatable cuff arranged between the proximal and distal ends of the elongate tubular member, and an electrode array disposed in proximity to an exterior surface of the inflatable cuff. The inflatable cuff can be configured to expand to contact a subject's tracheal wall. Additionally, the electrode array can include a plurality of flexible electrodes, where a set of the flexible electrodes anatomically align with a region of the subject's tracheal wall for selectively targeting vagus nerve activity.

A system for stimulating body tissue may include a stimulation lead, sensors, and a control unit. The stimulation lead may include one or more energy sources. The control unit may include a processor and non-transitory computer readable medium, and an interface (e.g., touch screen interface) for receiving user inputs and communicating information to the user. The sensors may be configured to provide impedance measurements to the control unit. The control unit may calculate lung gas distributions and/or generate an image modeling lung gas distributions. Stimulation delivered by the stimulation may be adjusted based on the impedance measurements.

A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting pain while preserving other sensory and motor function, and proprioception.

An example method includes receiving one or more physiological signals; detecting an apnea event based on the one or more physiological signals; determining that the apnea event cannot be characterized as one of a normal, OSA (obstructive sleep apnea), CSA (central sleep apnea), or combination OSA/CSA event; and outputting an electrical stimulation as a default based on determining that the apnea event cannot be characterized as a normal event, an OSA event, a CSA event, or combination OSA/CSA events.