An electrode arrangement for stimulating and recording electrical signals in biological matter comprises: an array (110) of electrodes (112), wherein electrodes (112) are configured to be switchable between stimulating and recording of electrical signals; a control unit (120), wherein the control unit (120) is configured to select a plurality of electrodes (112) to form a combined macroelectrode site (114) for providing a stimulating signal, wherein the control unit (120) is further configured to determine a perimeter electrode (112b) and a central electrode (112a), wherein the perimeter electrode (112b) is arranged at a perimeter of the combined macroelectrode site (114) and the central electrode (112a) is arranged centrally within the combined macroelectrode site (114), and wherein the control unit (120) is further configured to provide a stimulation signal to the perimeter electrode (112b) that has a lower magnitude than a stimulation signal provided to the central electrode (112a).

The present invention provides improved methods for positioning of an implantable lead in a patient with an integrated EMG and stimulation clinician programmer. The integrated clinician programmer is coupled to the implantable lead, wherein the implantable lead comprises at least four electrodes, and to at least one EMG sensing electrode minimally invasively positioned on a skin surface or within the patient. The method comprises delivering a test stimulation at a stimulation amplitude level from the integrated clinician programmer to a nerve tissue of the patient with a principal electrode of the implantable lead. Test stimulations are delivered at a same stimulation amplitude level for a same period of time sequentially to each of the four electrodes of the implantable lead. A stimulation-induced EMG motor response is recorded with the integrated clinician programmer for each test stimulation on each electrode of the implantable lead via the at least one pair of EMG sensing electrodes so as to facilitate initial positioning of the implantable lead at a target stimulation region.

Disclosed is an implantable device for lead offset determination, comprising first and second electrode leads. A stimulus is delivered from one lead to tissue, and a signal is sensed from the tissue by the other lead. The sensed signal is processed to produce a measure of a stimulus artefact present in the signal. The stimulus artefact measure is used to produce a measure of an offset between the first electrode lead and the second electrode lead, such as by applying a distance-squared. analytical model to measures of stimulus artefact obtained from at least two sense electrodes. And/or, a compound action potential evoked by the stimulus is sensed from neural tissue, a latency of the evoked compound action potential is measured, and a measure of an offset between the first electrode lead and the second electrode lead is produced from the latency.

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neutral- and non-neural tissue of the nervous structure, inhibiting the perception of pain while preserving other sensory and motor function, and proprioception.

Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system is configured to receive information representing a plurality of signals sensed from a tissue of a patient via a plurality of electrode combinations, wherein the plurality of electrode combinations comprises different electrode combinations comprising electrodes disposed at different positions of the lead implanted in the patient, determine one or more features from the information representing the plurality of signals, and compare the one or more features to a plurality of templates, each template of the plurality of templates representing respective locations of a signal source within the tissue. The system may then determine, based on the comparison of the one or more features to the plurality of templates, an estimated location of the signal source with respect to the lead.

Systems and methods which provide for and enable sensing responsive signals with respect to the application of paresthesia-free stimulation are described. Sensing signal initiators may be utilized comprising one or more non-therapeutic and/or non-tonic pulses in the form of pinging-pulses configured for invoking responsive signals suitable for measurement and/or analysis in association with the application of neural stimuli. A sensing signal initiator technique may provide an interleaved implementation to introduce one or more pinging-pulses between burst groups of a burst stimulation regimen. Additionally or alternatively, a sensing signal initiator technique may provide a postfixed implementation to introduce one or more pinging-pulses by modifying a therapeutic stimulation burst so that the last phase of the passive discharge is replaced with pinging-pulse providing an active discharge.

An implantable neurostimulator for delivering one or more stimulation pulses to a target region within a patient's body. The implantable neurostimulator including a housing and an energy storage feature. There is also a lead coupled to the hermetic housing and a plurality of electrodes located proximate to a distal end of the lead. The neurostimulator includes stimulation circuitry that includes an adjustable resistance element. A voltage of the electric signal derived from the energy storage feature and a resistance of the adjustable resistance element are both adjusted based on a measurement of a value indicative of a tissue impedance of the target region to provide a desired value of a stimulation current for the one or more stimulation pulses.

Graphical User Interface (GUI) control of a stimulator device is disclosed. The GUI receives modeling information indicating optimal stimulation parameters for a patient based on patient testing, and may also receive an indication of a particular stimulation mode to be used for the patient which comprises a subset of those parameters. The GUI provides simple options to allow a user to navigate the optimal parameters or subsets to constrain selection to only those stimulation parameters set within the optimal parameters or subsets.

A medical apparatus configured to neuromodulate tissue and/or record patient information is provided. The apparatus includes an external system to transmit transmission signal(s), each signal having at least power or data, and an implantable system to receive the transmission signal(s). The data transfer between the external and implantable systems is asynchronous. The external system includes external antenna(s) to transmit a transmission signal. The transmission signal is an amplitude modulated signal modulated by varying a load on the external antenna(s) that causes an impedance mismatch prior to amplifying the signal for transmission. An implantable device includes implantable antenna(s) to receive the transmission signal. The implantable system comprises a receiver to receive the transmission signal from the implantable antenna(s), implantable transmission module(s) to transmit data to the external system, and a variable load connected to the implantable antenna(s). Data is transmitted by varying the load.

Methods of performing diagnostic tests on electroencephalography (EEG) recording devices comprising at least one stimulator coupled with a plurality of EEG electrode recording channels and corresponding recording channel connectors are performed by a test fixture comprising a plurality of resistors coupled with one or more of the EEG electrode recording channels and corresponding recording channel connectors. The methods include performing an impedance test for determining if each EEG recording channel of the EEG recording device has a predefined impedance, performing a channel uniqueness test for each EEG recording channel, performing a test for verifying the state of a switch of the stimulator of the EEG recording device, and performing a test for verifying connector IDs of the recording channel connectors connecting the EEG electrodes to respective EEG recording channels.