A method includes: transmitting a first set of radio-frequency (RF) pulses to an implantable wireless stimulator device such that electric currents are created from the first set of RF pulses and flown through a calibrated internal load on the implantable wireless stimulator device; in response to the electric currents flown through a calibrated internal load, recording a first set of RF reflection measurements; transmitting a second set of radio-frequency (RF) pulses to the implantable wireless stimulator device such that stimulation currents are created from the second set of RF pulses and flown through an electrode of the implantable wireless stimulator device to tissue surrounding the electrode; in response to the stimulation currents flown through the electrode to the surrounding tissue, recording a second set of RF reflection measurements; and characterizing an electrode-tissue impedance by comparing the second set of RF reflection measurements with the first set of RF reflections measurements.

An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.

In one example, the disclosure describes a method comprising receiving, by processing circuitry, information indicative of one or more evoked compound action potential (ECAP) signals. The one or more ECAP signals are sensed by at least one electrode carried by a medical lead. The processing circuitry determining that at least one characteristic value of the one or more ECAP signals is outside of an expected range. Responsive to determining that the at least one characteristic value of the one or more ECAP signals is outside of the expected range, the processing circuitry performs a lead integrity test for the medical lead.

This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.

In some variations provided herein, a system for deep brain stimulation includes an implantable device that acquire and store neural activity signal records and apply electrical stimulation. The system further includes a personal controller device that establishes a first wireless connection to the implantable device. The personal controller device transmits power to the implantable device, and the implantable device transmits neural activity signal records to the personal controller device over the first wireless connection. The system further includes a clinician programmer device that receive the neural activity signal records from the implantable device by establishing a second wireless connection based on activation of the first wireless connection. The clinician programmer device sets one or more stimulation parameters based on the neural activity signal records.

A multipolar cannula, comprising: a cannula tube, which has a distal end and a proximal end; a first electrode; and at least one second electrode. The cannula tube has a cannula tube body and a coating, which electrically insulates the first and the second electrode from one another. The distal end of the cannula tube has a distal tip, and an attachment is arranged on the proximal end, which attachment has an electrically contacting connection point for the electrodes. The electrically insulating coating and at least the second electrode are applied to the cannula tube body in a thin-film process.

The techniques of the disclosure describe example medical devices, systems, and methods for delivering stimulation therapy comprising a first set of a plurality of pulses having a first amplitude, and a second set of a plurality of pulses having a second amplitude greater than the first amplitude. The second amplitude is adjusted to an adjusted second amplitude based on second amplitude being less than or greater than activation threshold. The first amplitude is adjusted based on adjusted second amplitude, and therapy is delivered based at least one the adjusted first amplitude.

A device for delivery of electrical pulses to a desired tissue of a mammal. The device comprises a pulse generating device and an electrode device connected to the pulse generating device. The pulse generating device is configured to determine conductance and phase angle values between one electrode and a reference electrode of the electrode device when the electrode device is inserted into the desired tissue and when pulses based on alternating currents having different frequencies are generated between the electrode and the reference electrode. Based on the determined conductance and phase angle values, the pulse generating device is configured to determine the type of tissue the electrode device penetrates, to determine one or more parameters of electrical pulses to be delivered to the desired tissue and to generate the electrical pulses having the determined one or more parameters.

A neuromodulation system and method with feedback optimized electrical field generation for stimulating target tissue of a patient to treat neurological and non-neurological conditions. The system generally includes implantable electrodes, implantable sensors, an implantable or external electrical signal generator, and an implantable or external controller. The controller controls the electrical signal generator to generate electrical noise stimulation signals that are delivered to the target tissue via the electrodes and that produce an optimized electric field having maximized voltage with low current density. The sensors produce temperature and impedance data for the target tissue and the controller automatically responds to values of the sensor data that indicate potential damage to the target tissue to reduce the strength of the electric field.

This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.