Wirelessly powered implantable pulse generators (IPG) are described. In an embodiment, a wirelessly powered stimulator, includes an implantable pulse generator (IPG), including: an Rx antenna that receives a radio frequency (RF) signal from an external Tx antenna; a rectifier; an energy storage capacitor C.sub.STOR, where the RF signal coupled to the Rx antenna is rectified by the rectifier to generate VDD and charges the C.sub.STOR; a demodulator; an output voltage regulator that generates a stable voltage to activate the demodulator; and where the demodulator outputs a stimulation that releases the energy stored in the C.sub.STOR on an electrode based on detecting amplitude modulation in the received RF signal; and a Tx antenna that generates the RF signal that wirelessly powers the IPG and that controls timing of output stimulations of the IPG, where amplitude modulation is applied to the RF signal to control the timing of the output stimulations.

Systems and methods for treating a patient's pain using ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods are disclosed. A representative method for treating a patient includes positioning an implantable signal delivery device proximate to a target location at or near the patient's spinal cord, and delivering an electrical therapy signal to the target location via the implantable signal delivery device, wherein the electrical therapy signal has a frequency in a frequency range of from about 1 kHz to about 100 kHz, and wherein the frequency is increased or decreased from a first value to a second value during delivery.

In an embodiment herein, an aortopulmonary stimulation method is provided including positioning at least one aortic electrode in or near the aorta, and using the at least one aortic electrode, to deliver stimulation to the aorta to decrease aortic after load.

A method of stimulating nerve tissue, a tissue stimulation system, and an external control device are provided. The method, system, and control device causes an electrical stimulus to be applied to at least one electrode adjacent the nerve tissue of a patient. The applied electrical stimulus comprises a plurality of pulses defined by a pulse width value and an amplitude value. The pulse amplitude value is increased (e.g., manually), and the pulse width value is automatically decreased in response to increasing the pulse amplitude value in a manner that increases the intensity of the applied electrical stimulus. Alternatively, the pulse width value may be decreased (e.g., manually), and the pulse amplitude value automatically increased in response to decreasing the pulse width value in a manner that increases the intensity of the applied electrical stimulus.

A neuromodulation system including at least one input module for inputting a planned neuromodulation event or a series of neuromodulation events and at least one analyzing module for analyzing a neuromodulation event or a series of neuromodulation events. The analyzing module and the input module may be connected such that the input module is configured to forward the planned neuromodulation event or a series of neuromodulation events to the analyzing module and the analyzing module is configured to analyze the planned neuromodulation event or a series of neuromodulation events regarding one or more possible neuromodulation conflict(s).

Synchronized stimulation of cardiac tissue can be implemented by implanting two or more rectifier-based AM receivers into different positions within a subject's heart. Each receiver is tuned to a different frequency, and generates an output signal that is capable of stimulating cardiac tissue when a signal at the corresponding tuned frequency arrives at the receiver. An AM transmitter can activate any given one of the receivers by transmitting a signal into the subject's body at the proper frequency. A controller controls the transmitter by commanding the transmitter to transmit pulses of AC at different frequencies at different times, so that when those pulses are received by the correspondingly-tuned receivers, each of the receivers will generate respective output signals that stimulate respective parts of the heart at respective times to promote improved cardiac performance.

An apparatus, system and technique selectively eliminates the noxious signal components in a neuronal signal by creating an interfering electrical signal that is tuned to a given frequency corresponding to the oscillatory pattern of the noxious signal, resulting in a modified neuronal signal that substantially reproduces a normal, no-pain neuronal signal. The disclosed system and technique of pain relief is based on the hypothesis that the temporal profile of pain signals encodes particular components that oscillate at unique and quantifiable frequencies, which are responsible for pain processing in the brain.

An implantable neurostimulator for delivering one or more stimulation pulses to a target region within a patient's body. The implantable neurostimulator including a housing and an energy storage feature. There is also a lead coupled to the hermetic housing and a plurality of electrodes located proximate to a distal end of the lead. The neurostimulator includes stimulation circuitry that includes an adjustable resistance element. A voltage of the electric signal derived from the energy storage feature and a resistance of the adjustable resistance element are both adjusted based on a measurement of a value indicative of a tissue impedance of the target region to provide a desired value of a stimulation current for the one or more stimulation pulses.

A method of forming an activated coating composition is disclosed. The method includes providing (a) boron nitride, (b) carbon, (c) aluminum oxide and (d) a liquid carrier. Each of the boron nitride, carbon and aluminum oxide are in particulate form. The coating composition is activated to form an activated coating composition. The activated coating composition includes active components having from about 60.0 wt% to about 90.0 wt% boron nitride, from about 16 wt% to about 24 wt% carbon and from about 4 wt% to about 6 wt% aluminum oxide. A coating method, coated substrate and activated coating composition are also disclosed.

The present invention relates to a multi-target electrical stimulation circuit, an electrical stimulator, and a signal output method of the electrical stimulator. The electrical stimulation circuit includes a control module, a plurality of brain wave acquisition modules and a plurality of stimulation adjustment modules. Each electrode is correspondingly provided with one brain wave acquisition module and one stimulation adjustment module, and different electrodes are used for stimulating different targets. The brain wave acquisition modules are used for acquiring brain wave signals in the corresponding electrodes and transmitting the brain wave signals to the control module. The control module is used for acquiring brain rhythm phase signals according to the received brain wave signals and outputting stimulation signals at preset waveform phase points after phase locking of the brain rhythm phase signals. The stimulation adjustment modules are used for adjusting brain wave stimulation signals output to the corresponding electrodes according to the received stimulation signals. The multi-target electrical stimulation circuit, the electrical stimulator and the signal output method provided by the present invention are beneficial for achieving electrical stimulation of a plurality of targets as well as time-locked matching of electrical stimulation of a plurality of targets.