Systems and techniques are disclosed to adjust programming of an implantable electrical neurostimulation device for treating chronic pain of a human subject, through the use of a dynamic model adapted to identify pain treatment parameters for a human patient and determine a best device operational program to implement the pain treatment parameters to address the chronic pain condition. In an example, the system to adjust programming of the neurostimulation device performs operations that: obtain data related to a state of pain of the human subject; identify pain treatment parameters using a dynamic model adapted to evaluate the pain treatment parameters in the human subject over a time period, based on the data related to the state of pain; and select a neurostimulation program for the neurostimulation device, corresponding to at least a portion of the identified pain treatment parameters.

An implantable medical device for stimulating a human or animal heart, comprising a first processor, a first memory unit, a stimulation unit configured to stimulate a first cardiac region of a human or animal heart, and a detection unit configured to detect an electric signal at the first cardiac region of the same heart, wherein the detection unit comprises i) an electrode lead having an electrode pole and ii) a first channel for measuring electric signals provided by the electrode lead. A maximum sensitivity of the first channel of the detection unit is adjustable in dependence on a stimulation site of the electrode pole, wherein the maximum sensitivity of the first channel lies in a range of from 0.1 mV to 0.4 mV if the electrode pole is intended to detect electric signals at the His bundle of the heart.

A programming device for programming an implantable medical device for stimulating a human or animal heart, wherein the following steps are performed: a) allowing to select one of at least two electrode lead configurations for stimulating a human or animal heart, wherein the at least two electrode lead configurations comprise a second electrode lead configuration in which at least one electrode lead is connected to an electrode lead port, the electrode lead port being configured to receive an electrode lead for stimulating a second cardiac region or detecting an electric signal at the second cardiac region, wherein the second cardiac region is a part of a ventricular conduction system of the heart, wherein the at least one electrode lead is intended to be implanted or is implanted in the second cardiac region; b) generating and releasing a notification signal if the second electrode lead configuration is selected.

An implantable medical device for stimulating a human or animal heart. In operation, the device performs the following steps: a) sensing an atrial electric signal a the first detection unit; b) sensing an electric signal at the His bundle with a second detection unit upon termination of a first time period starting upon sensing the atrial electric signal with the first detection unit and/or starting upon applying a stimulation pulse, wherein the first time period lies in a range of from 10 ms to 100 ms; c) classifying the electric signal sensed with the second detection unit as His bundle activity signal or as ventricular activity signal.

An implantable medical device for stimulating a human/animal heart, comprising a first electrode lead port for receiving an electrode lead. The first electrode lead port comprises a first marking element and a second marking element, wherein the first marking element indicates a first kind of electrode lead that can be received by the first electrode lead port and for an operation of which the first electrode lead port is designed to be configured, wherein the first kind of electrode lead is a His bundle electrode lead , wherein the second marking element indicates a second kind of electrode lead that can be received by the first electrode lead port and for an operation of which the first electrode lead port is designed to be configured. The second kind of electrode lead includes one of an atrial electrode lead, a right ventricular electrode lead, and a left ventricular electrode lead.

A programming device for programming an implantable medical device for stimulating a human or animal heart, wherein the programming device carries out the steps: a) allowing to select one of at least two electrode lead configurations for stimulating a heart, wherein the at least two electrode lead configurations comprise: i) a first electrode lead in which an atrial electrode lead and a right ventricular electrode lead are connected to electrode lead ports, and ii) a second electrode lead in which an atrial electrode lead and a His bundle electrode lead are connected to electrode lead ports; b) allowing to select a first timing parameter value if the first electrode lead is selected and to select a second timing parameter value if the second electrode lead is selected, wherein the first timing parameter value is an atrioventricular interval and the second timing parameter value is an atrial-His interval.

An implantable medical device for stimulating a human/animal heart having a stimulation unit which stimulates the His bundle and a detection unit which detects an electrical signal at the His bundle. The device performs: a) determining a first value of a parameter of a first measuring pulse measured between a first electrode pole and a housing; b) determining a second value of the same parameter of a second measuring pulse measured between the first electrode pole and a second electrode pole; c) comparing the first and second values; d) determining, based on the comparing step, whether the first or second measuring pulses enables a higher available level control range of the analog-to-digital converter; e) measuring an impedance in a unipolar manner between the first electrode pole and the housing or in a bipolar manner between the first electrode pole and the second electrode pole depending on the determining step.

An interface relay system for use with a fully implantable medical devices that permits transcutaneous coupling of the implanted medical device to a consumer electronics device. In one embodiment, coupling the implanted medical device to the external electronics device provides a back-up source of power for operating the implanted medical device. In another embodiment, coupling the implanted medical device to the external electronics device allows for providing unidirectional and/or bidirectional data transfer between the devices. In one arrangement, the consumer electronics device may be connectable to a communications/data network to allow for network communication between the implantable medical device and a remote processing platform/server.

Systems and techniques are disclosed to adjust programming of an implantable electrical neurostimulation device for treating chronic pain of a human subject, through the use of a dynamic model adapted to identify pain treatment parameters for a human patient and determine a best device operational program to implement the pain treatment parameters to address the chronic pain condition. In an example, the system to adjust programming of the neurostimulation device performs operations that: obtain data related to a state of pain of the human subject; identify pain treatment parameters using a dynamic model adapted to evaluate the pain treatment parameters in the human subject over a time period, based on the data related to the state of pain; and select a neurostimulation program for the neurostimulation device, corresponding to at least a portion of the identified pain treatment parameters.

Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region to address low back pain without creating unwanted sensory and/or motor side effects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.