A gear-driven infusion assembly is provided which has a housing, a gear assembly coupled to the housing, a shuttle assembly slidably coupled to the housing and operably coupled to the gear assembly, and a tube enclosure connected to the housing. The tube enclosure is configured to house a primary drug closure. The gear assembly includes a spool assembly having a pinion gear and a drive spool. When the spring rotates the drive spool, the drive spool drives the pinion gear, and the gear assembly drives the shuttle assembly. When the gear assembly drives the shuttle assembly, the shuttle assembly slides longitudinally along the housing. The gear assembly may be spring driven such that a spring rotates the pinion gear about the drive spool. The primary drug closure may be a syringe. An overspeed protection device is also provided which has a spool assembly including a drive spool having a plurality of cams, a spring, and a pinion gear with spiral cam surfaces.

An injector apparatus includes a housing (10.sup.1, 10.sup.2) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.

A method of assembling a drug delivery device, comprising the steps of: inserting a piston rod in a nut portion of a cartridge assembly and rotating the piston rod until the piston rod distal end engages the cartridge piston, mounting a drive member on the piston rod in a rota-tional position being closest to a pre-determined rotational position, and rotating the drive member to the pre-determined rotational position.

According to some embodiments, a syringe may include a barrel; a delivery conduit; a plunger seal disposed within the barrel; and a plunger rod assembly affixed to an end of the barrel, the plunger rod assembly including a first plunger rod component comprising a first linear gear, a second plunger rod component disposed at least partially in the barrel and engaged with the plunger seal, wherein the second plunger rod component comprises a second linear gear, a first rotational gear having a plurality of gear teeth for engaging the first linear gear, and a second rotational gear having a second plurality of gear teeth for engaging the second linear gear, wherein the first rotational gear is coupled to the second rotational gear such that translation of the first plunger rod component causes translation of the second plunger rod component.

Dosing device for an administration device with a limiting mechanism containing: a dosing sleeve with a first stop and a stop wheel with a second stop means adapted to continually and proportionally follow a movement of the dosing sleeve during dosing movements. During an ejection movement, there is no relative movement between dosing sleeve and stop wheel. The first stop and the second stop each describe a path curve by their movements such that the two path curves intersect in one point and the stops contact one another and tilt the stop wheel, thereby blocking the dosing movement of the dosing sleeve. The stop wheel comprises first and third sloped surfaces that may form first and second gear guidances with a clutch thereby returning the stop wheel to a non-tilted position during up or down dosing movements when the stops do not contact another.

An injection device having a drive member with first and second gear patterns that are fixed relative to each other. The drive member is rotatable and translatable in first and second opposing axial directions. A plunger expels medicament from a cartridge when it is translated in an advancing direction. A dosage indicator indicates a set dosage. A first gearing arrangement operably couples the first gear pattern with the plunger wherein rotation of the drive member in a first direction translates the drive member in a first axial direction without movement of the plunger and translation of the drive member in the opposite axial direction drives the plunger in the advancing direction. A second gearing arrangement operably couples the second gear pattern with the dosage indicator and moves the dosage indicator to indicate an increase in the set dosage when the drive member is translated in the first axial direction.

An autoinjector device includes a dose cassette having an outer container and a needle cap having a base with a diameter larger than the outer container of the dose cassette. The autoinjector device further include a housing for receiving the dose cassette, a clasp mechanism configured to hold the dose cassette within the housing, and an actuator configured to move the dose cassette proximally within the housing after the dose cassette is secured within the housing. The movement of the dose cassette causes the base of the needle cap to mechanically engage with a distal end of the housing, and the mechanical engagement between the base of the needle cap and the distal end of the housing causes the needle cap to separate from the dose cassette.

The present disclosure is generally directed to a drive mechanism for use in a drug delivery device having a cylindrical cartridge, i.e. a handheld injection device for selecting and dispensing a number of user variable doses of a medicament. The drive mechanism includes a base element, a toothed piston rod, which is guided within and movable relative to the base element, and a drive gear having a pinion, which is rotatably held in the base element and in meshed engagement with the toothed piston rod. The toothed piston rod includes multiple rigid rod pieces which are connected by hinges. The rigid rod pieces comprise a flat plate provided with a straight toothed rack.

An autoinjection housing device includes a housing for receiving a dose cassette, a base latch configured to hold the dose cassette within the housing, and a back plate operably connected to a spring. The back plate is configured to move proximally within the housing upon receipt of the dose cassette into the housing, and the proximal movement of the back plate compresses the spring. The autoinjection housing device further includes an actuator operably connected to the base latch. The actuator is configured to move the base latch and the dose cassette proximally within the housing after the dose cassette is secured in the housing. The base latch is configured to move radially outwards upon said proximal movement of the base latch within the housing. The radial movement of the base latch is configured to cause the dose cassette to become unsecured within the housing. In response to the dose cassette becoming unsecured, the spring decompresses, causing the back plate to move distally and push the dose cassette out of a distal end of the housing.

Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.