Differential charge-balancing can be used in high-frequency neural stimulation. For example, a neural stimulation apparatus can have first and second electrodes configured to be coupled proximate to a nerve fiber to implement a neural stimulation procedure. A neural stimulation circuit can be electrically coupled to the first and second electrodes. The neural stimulation circuit can apply stimulation currents to the nerve fiber through the first and second electrodes during a first stimulation phase of the neural stimulation procedure. The neural stimulation circuit can also apply a modified stimulation current to the nerve fiber through the first electrode during a second stimulation phase of the neural stimulation procedure. The modified stimulation current can be generated based on a difference between (i) a voltage at the first electrode, and (ii) a reference voltage derived from voltages on the first and second electrodes.

Techniques are disclosed for implementing the use of electrically evoked compound action potentials (ECAPs) to adaptively adjust parameters of high frequency electrical stimulation. In one example, a medical device delivers electrical stimulation therapy comprising a train of electrical stimulation pulses to a patient, wherein the train of electrical stimulation pulses comprises a pulse frequency greater than or equal to 500 Hertz. After delivering the train of electrical stimulation pulses, the medical device ceases delivery of the high frequency electrical stimulation therapy for a predetermined period of time. During the predetermined period of time, the medical device senses an ECAP from the patient and determines, based on the sensed ECAP, a value of a parameter at least partially defining the train of electrical stimulation pulses. Responsive to the predetermined period of time elapsing, the medical device resumes delivery of the high frequency electrical stimulation according to the determined parameter.

The present disclosure relates to a system for neuromodulation and/or neurostimulation, for the treatment of a subject. The system comprises a stimulation controller, a stimulation pattern storage means including stimulation data connected to the stimulation controller, an electrical stimulation device and electrical interface between the electrical stimulation device and the subject, the electrical interface being connectable with a bio-interface of the nervous system of the subject. The stimulation data are pre-programmed patterns comprising spatial and temporal components, The stimulation controller sends configuration signals on the basis of the stimulation data to the electrical stimulation device such that via the electrical interface electrical stimulation is provided to the bio-interface, wherein the electrical stimulation provided is characterized by stimulation parameters that vary over time in a pre-programmed manner.

A method includes configuring, by a computing device, stimulation settings for each electrode in an at least one electrode array in physical contact with a patient, the stimulation settings having adjustable parameters comprising frequency, pulse width, and amplitude, obtaining, by the computing device, feedback information from the patient, and automatically adjusting, by the computing device, at least one of the adjustable parameters based on the feedback information from the patient.

Disclosed herein are systems and methods that can involve a neuromodulation device configured to perform in multiple electrical modulation modes with a single architecture.

A neural stimulator system which generates stimulation from an implantable stimulator circuit which generates stimulation outputs which mimic biological signals. The user/operator can select stimulation generated from recorded waveforms, or by selecting the characteristics for generating stimulation based on randomized inter-pulse-intervals (IPI). A control unit controls the operation of the implantable stimulator circuit, and receives sets of stimulation parameters based on user input from a user input device executing application specific programming.

A method for assisting and tracking a user with a neurological disorder includes receiving, from a user interface, a selection of a physical activity that the user wishes to perform. The method further includes sending a control signal to a neurostimulation device, the control signal including instructions for the neurostimulation device to implement a neurostimulation therapy regimen corresponding to the selected physical activity that the user wishes to perform. The method also includes receiving an activity feedback signal from at least one sensor, the activity feedback signal including information regarding performance of the selected physical activity when performed by the user. The method further includes sending a monitoring signal to a remotely located caregiver device, the monitoring signal including activity data derived from the information regarding performance of the selected physical activity.

The present technology is generally directed to wearable devices for treating sleep apnea, and associated systems and methods. In some embodiments, a system for treating sleep apnea comprises an implantable device and a wearable device. The implantable device can be implantably positionable at a patient's head and/or neck, proximate to the patient's oral cavity, and include a signal generator configured to generate an electrical signal, an electrode coupled to the signal generator to direct the electrical signal to the patient's tissue, and a power receiver device coupled to the signal generator. The wearable device can include a power source and a power transmission device coupled to the power source and configured to transmit power wirelessly to the implantable device.

A method of downregulating and/or upregulating neural activity by applying a high frequency alternating current electrical signal to a nerve in a subject is disclosed. The signal comprises more than one microsecond cycle comprising one or more periods, each period comprising a charge recharge phase, and optionally, a pulse delay, each period having a frequency of at least 1000 Hz; and a microsecond inactive phase. In embodiments, an electrical signal treatment comprises more than one microsecond cycle to form a millisecond cycle, each millisecond cycle separated by a millisecond inactive phase during an on time. In embodiments, the electrical signal patterns can differ in amplitude.

Systems and methods for treating a patient having a blood glucose abnormality, such as type 2 diabetes (T2D), using an electrical signal are disclosed. A representative method for treating a patient includes, based at least in part on a patient indication of a blood glucose abnormality, positioning at least one implantable signal delivery device proximate to a target location at the patient's spinal cord within a vertebral range of from about C8 to about T12. The method further includes directing an electrical signal to the target location via the implantable signal delivery device, wherein the electrical signal has a frequency in a frequency range of from 1.2 kHz to 100 kHz.