A method for selective activation of central thalamus fibers in a subject is disclosed. The method involves providing one or more electrodes each with one or more contacts. The one or more electrodes are positioned in the subject’s central thalamus fibers. An electrical stimulus is applied to the positioned one or more electrodes to selectively activate the central thalamus fibers of the subject. The positioning and applying are carried out to maximize central lateral nucleus and medial dorsal tegmental tract fiber pathway activation in the subject and to minimize central median parafascicularis fiber pathway activation in the subject. Methods, devices, and computer readable media for surgical planning involving selective activation of central thalamus fibers in a subject are also disclosed.

The present disclosure provides advantageous post and partition assembly that is configured and adapted to promote modularity and withstand the harsh environment of central sterile processing processes. Modular post assembly may be removed and relocated on tray without additional fasteners or components. Tray and bracket assembly may further provide identification features to correctly associate cataloged reusable medical devices to identified trays.

Provided herein is method of modulating a plurality of neurons in a patient, by stimulating an area of the patient's central nervous system. The stimulation includes alternating first periods when a plurality of pulses of electrical stimulation are delivered and second periods when no pulses of electrical stimulation are delivered. The first periods have a duration of about 100 to about 400 ms and the second periods have a duration of about 500 ms to about 1900 ms. The pulses have a frequency of about 100 Hz to about 250 Hz.

A method for assessing treatment of a subject who has overactive bladder (OAB) includes using an implant to stimulate a tibial nerve of the subject according to a stimulation protocol. An electronic processor is used to receive, from one or more sensors, data indicative of activity of the subject over a time period extending over at least one week. Based on the data, a characteristic of a response of the subject to the stimulation is assessed. Other embodiments are also described.

A computer brain interface (CBI) device of an individual is self-calibrated. A neurostimulation test signal is generated based on a selected set of test signal parameters. The neurostimulation signal is applied to the afferent sensory nerve fibers to elicit a bioelectric response via a neurostimulation interface operably connected to or integrated with the CBI device. The neurostimulation interface senses the bioelectric responses of the stimulated afferent sensory nerve fibers. The CBI devices determines, based on the sensed bioelectric responses, whether an excitation behavior of the stimulated afferent sensory nerve fibers with respect to the neurostimulation interface has changed. When the excitation behavior has changed, a set of recalibrated neurostimulation signal parameters is determined based on the sensed bioelectric responses. The CBI device is operated using the recalibrated neurostimulation signal parameters to communicate information to the individual via neurostimulation of the afferent sensory nerve fibers.

The present disclosure relates to treatment of reflux disease of a human patient. More particularly, a device is disclosed, which is configured to be implanted in the body of the human to restrict movement of the cardia of the patient's stomach towards the diaphragm opening into the patient's thorax, and/or to prevent stomach contents from passing from the stomach into the esophagus.

An example system includes a memory; and processing circuitry configured to: cause an implantable stimulation device to deliver a plurality of doses of electrical stimulation to a patient; receive, for each respective dose of the plurality of doses, a respective electrical signal of a plurality of electrical signals; and determine, based on a variation of the plurality of electrical signals, whether the plurality of doses of electrical stimulation evoked neural potentials in the patient.

A computer brain interface (CBI) device of an individual applies a burst sequence of stimulation pulses to afferent sensory nerve fibers to elicit a bioelectric response via a neurostimulation interface operably connected to or integrated with the CBI device. The neurostimulation interface senses the bioelectric responses of the stimulated afferent sensory nerve fibers. The CBI device derives, based on the sensed bioelectric responses, a neural excitability profile characterizing a non-linear, dynamic excitation behavior of the afferent sensory neurons corresponding to the applied sequence of stimulation pulses. At least one stimulation parameter of the current set of stimulation parameters is adjusted based on the derived excitability profile to obtain an updated set of stimulation parameters.

Disclosed are various examples and embodiments of systems, devices, components and methods configured to treat mood disorders in a patient using a compact implantable neurostimulator and corresponding lead(s) that are shaped, sized and configured to be implanted beneath a patient's skin in the head or neck, and to stimulate one or more target cranial nerves. The one or more medical electrical leads comprising electrode(s) are positioned adjacent to, in contact with, or in operative positional relationship to, the one or more target cranial nerves of the patient. In some embodiments, electrical stimulation is provided to the one or more target cranial nerve(s) of the patient for periods of time ranging between 30 and 60 minutes, once or twice per day. In some embodiments, power is provided to the implantable neurostimulator transcutaneously by inductive, wireless, RF, acoustic, microwave, or other suitable non-invasive means.

A method of providing electrical stimulation therapy to a patient according to one embodiment includes generating an un-tuned electrical noise signal by at least one noise generator, partitioning the un-tuned electrical noise signal into a plurality of discrete frequency bands having corresponding bandwidths, delivering the un-tuned electrical noise signal through one or more electrodes to the patient to target the patient's central or peripheral nervous system, adjusting, for each of a plurality of selected frequency bands, an amplitude of the voltage or current of the un-tuned electrical noise signal within a corresponding frequency band to generate an adjusted electrical stimulation signal based on feedback received from the patient, wherein the adjusted electrical stimulation signal includes a plurality of local maxima and a plurality of local minima, and delivering the adjusted electrical stimulation signal through the electrodes to provide electrical stimulation therapy to the patient.