An implantable electroacupuncture device (IEAD) treats Parkinson's disease or Essential Tremor through application of stimulation pulses applied to at least one of the acupoints on the chorea line. The IEAD includes an hermetically-sealed implantable electroacupuncture (EA) device and a conduit extending therefrom. At least one electrode is located on the outside of the housing. At least one electrode is located at an opening formed through the conduit. The housing contains a primary power source and pulse generation circuitry. A sensor wirelessly senses externally-generated operating commands, such as ON, OFF and AMPLITUDE. The pulse generation circuitry generates stimulation pulses. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen.

Applying therapeutic neural stimuli involves monitoring for at least one of sensory input and movement of a user. In response to detection of sensory input or user movement, an increased stimulus dosage is delivered within a period of time corresponding to a duration of time for which the detected sensory input or user movement gives rise to masking, the increased stimulus dosage being configured to give rise to increased neural recruitment.

Methods of providing electrical neural modulation to a patient's brain are disclosed herein. The methods involve differentially modulating two or more target regions of the brain. For example, a first target region may be provided with an electrical neural modulation signal that activates that target region while a second target region is provided with an electrical neural modulation signal that suppresses or deactivates that target region. As the implantable pulse generators (IPGs) described herein include independent current sources, such differential modulation can be provided with a single IPG.

A system for stimulating body tissue may include a stimulation lead, sensors, and a control unit. The stimulation lead may include one or more energy sources. The control unit may include a processor and non-transitory computer readable medium, and an interface (e.g., touch screen interface) for receiving user inputs and communicating information to the user. The sensors may be configured to provide impedance measurements to the control unit. The control unit may calculate lung gas distributions and/or generate an image modeling lung gas distributions. Stimulation delivered by the stimulation may be adjusted based on the impedance measurements.

A method of downregulating and/or upregulating neural activity by applying a high frequency alternating current electrical signal to a nerve in a subject is disclosed. The signal comprises more than one microsecond cycle comprising one or more periods, each period comprising a charge recharge phase, and optionally, a pulse delay, each period having a frequency of at least 1000 Hz; and a microsecond inactive phase. In embodiments, an electrical signal treatment comprises more than one microsecond cycle to form a millisecond cycle, each millisecond cycle separated by a millisecond inactive phase during an on time. In embodiments, the electrical signal patterns can differ in amplitude.

A medical device for electrical stimulation of a patient. A pulse generator generates current pulses for the electrical stimulation. An electrode lead with a plurality of electrode contacts delivers the pulses to tissue of the patient. The pulse generator repeatedly delivers a current pulse between two electrodes forming a first group and delivers a charge balancing current pulse after each current pulse between the electrodes of the first group. The respective current pulse is separated from the succeeding charge balancing current pulse by an inter pulse interval. The respective current pulse has an amplitude with the same absolute magnitude as the succeeding charge balancing current pulse, but is of opposite sign. The pulse generator delivers between each current pulse and the succeeding charge balancing current pulse a current pulse between two further electrodes forming a second group of electrode contacts of the plurality of electrode contacts.

Devices, systems, and techniques are described for adjusting therapy parameters defining electrical stimulation therapy. An example system includes a stimulation generator comprising a voltage stack configured to provide a stack voltage based on a multiplier of a battery voltage and processing circuitry. The processing circuitry receives a first set of parameter values that use a first stack voltage of the voltage stack to provide a first electrical stimulation defining a first therapy. The processing circuitry also determines, based on a second stack voltage lower than the first stack voltage, a second set of parameter values that define a second electrical stimulation, the second set of parameters defining a lower amplitude of electrical stimulation. Additionally, the processing circuitry controls the stimulation generator to deliver the second electrical stimulation according to the second set of parameter values using the second stack voltage of the voltage stack.

Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system is configured to receive, for each electrode combination of a plurality of electrode combinations, information representing a signal sensed in response to first electrical stimulation delivered to a patient via a lead, wherein the plurality of electrode combinations comprise different electrode combinations comprising electrode disposed at different positions around a perimeter of the lead implanted in the patient. The system may also be configured to determine, based on the information for each electrode combination of the plurality of electrode combinations, values for a threshold at different locations around the perimeter of the lead and determine, based on the values for the threshold, one or more stimulation parameter values that at least partially define second electrical stimulation deliverable to the patient via the lead.

An example method includes determining, by an implantable medical device (IMD), an electrode of a plurality of electrodes of a lead to be used to deliver electrical stimulation to a patient at a particular time; selecting, by the IMD and based on the determined electrode, a set of electrodes of the plurality of electrodes; and sensing, by the IMD and via the selected set of electrodes, electrical signals of the patient at the particular time.

Devices, systems, and techniques are described for adjusting therapy parameters defining electrical stimulation therapy delivered by multiple electrodes while maintaining a ratio of a value of a therapy parameter between the multiple electrodes. In one example, a device defines a relationship for multiple electrodes that defines a ratio of a value of a therapy parameter between the multiple electrodes. The device performs a master adjustment that adjusts each value of the therapy parameter for each respective electrode of the multiple electrodes by an amount specified by the relationship to maintain the ratio of the value of the therapy parameter between the multiple electrodes. The device controls delivery of electrical stimulation therapy according to the master adjustment.