A hippocampal prosthesis for bypassing a damaged portion of a subject's hippocampus and restoring the subject's ability to form long-term memories. The hippocampal prosthesis includes a first set of hippocampal electrodes configured to receive an input signal from at least one of the subject's hippocampus or surrounding cortical region. The hippocampal prosthesis includes a processing device having a memory and one or more processors operatively coupled to the memory and to the first set of hippocampal electrodes. The processing device being configured to generate an output signal based on the input signal received from the first set of hippocampal electrodes. The hippocampal prosthesis includes a second set of hippocampal electrodes operatively coupled to the one or more processors and configured to receive and transmit the output signal to the subject's hippocampus.

Pulse pattern detecting circuitry for use with a fractional voltage multiplier of a neurostimulation system is provided. The pulse pattern detecting circuitry is configured to detect an initial overlap of a repeating pulse pattern, wherein the repeating pulse pattern is generated by a plurality of pulse engines that generate pulses at different frequencies, the initial overlap occurring when pulses generated by each of the plurality of pulse engines occur simultaneously, detect a subsequent overlap of the repeating pulse pattern, the subsequent overlap of the pulse pattern occurring when pulses generated by each of the plurality of pulse engines again occur simultaneously, detect a plurality of events between the initial overlap and the subsequent overlap, each event corresponding to at least one of the plurality of pulse engines generating a pulse, and record a voltage multiplier setting for each of the plurality of detected events.

A system for sleep apnea treatment includes an implantable medical device (IMD) coupled to a first lead and a second lead, wherein the IMD comprises a processor and stimulation circuitry, and wherein the processor is configured to cause the stimulation circuitry of IMD to: transmit a first stimulation signal to the first lead to stimulate at least one of an ansa cervicalis, a glossopharyngeal nerve, tensor veli, levator veli, and digastric anterior of a patient, and transmit a second stimulation signal to the second lead to stimulate at least one a hypoglossal nerve or a phrenic nerve of the patient.

Disclosed herein are deep-brain stimulation (DBS) systems and methods for the treatment of Tourette Syndrome (TS). The DBS methods described herein comprise a stimulation paradigm that may help to reduce the frequency and/or severity of motor and vocal tics, as well as rapid and involuntary muscle motions that are characteristic of TS. One variation of a method for the treatment of TS comprises adjusting electrical stimulation to a target brain region based on changes or variations in the neural activity signals in the target brain region. One example of a method described herein comprises monitoring the power values (e.g., spectral power values) of one or more frequency bands of the acquired neural activity signals and adjusting electrical stimulation parameters based on at least one variation or change of the monitored power values.

Systems and methods for providing electrostimulation to a neural target are discussed. An example system comprises an implantable stimulator and a controller. The implantable stimulator can provide burst stimulation comprising a pulse train followed by a pulse-free period. The controller can detect an indication of frequency drift of an intrinsic oscillatory neural activity, and in response to the indication of frequency drift, calibrate a burst stimulation parameter including a burst frequency or a timing for initiating the burst stimulation at a particular phase of an oscillation cycle of the intrinsic oscillatory neural activity. The controller can generate a control signal to the implantable stimulator to generate burst stimulation in accordance with the calibrated burst stimulation parameter.

A motor device for stimulating muscle, including at least one electrode for generating electric current operatively attached to an electrode array and exposed on an inner surface of an array body, and a programming mechanism of a computer that executes an algorithm stored on non-transitory computer readable medium and includes an information storage mechanism and a user-operated interface in electrical connection with said at least one electrode for programming operation of said at least one electrode, said motor device being implanted in an individual and applying electric current to nerves at an area above an area of neurological damage.

A neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of electrodes, a user interface configured for receiving input from a user that selects one of a plurality of different shapes of a modulating signal and/or selects one of a plurality of different electrical pulse parameters of an electrical pulse train, neuromodulation output circuitry configured for outputting an electrical pulse train to the plurality of electrical terminals, and pulse train modulation circuitry configured for modulating the electrical pulse train in accordance with the selected shape of the modulating signal and/or selected electrical pulse parameter of the electrical pulse train.

This application is generally related to systems and methods for providing a medical therapy to a patient by tracking patient activity and adjusting medical therapy based on occurrence of different types of activities performed by the patient while automatically rescheduling stimulation programs based on detected patient activity.

A medical apparatus for a patient comprises an external system and an implantable system. The external system is configured to transmit one or more transmission signals, each transmission signal comprising at least power or data. The implantable system is configured to receive the one or more transmission signals from the external system, and to deliver stimulation energy to the patient. Methods of delivering stimulation energy are also provided.

Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods are disclosed. A representative method in accordance with an embodiment of the disclosure includes creating a therapeutic effect and a sensation in a patient by delivering to the patient first pulses having a first set of first signal delivery parameters and second pulses having a second set of second signal delivery parameters, wherein a first value of at least one first parameter of the first set is different than a second value of a corresponding second parameter of the second set, and wherein the first pulses, the second pulses or both the first and second pulses are delivered to the patient's spinal cord.