The present disclosure provides an apparatus for stimulating neural activity in a pudendal nerve of a subject, the apparatus comprising of: at least one primary electrode configured to apply a first electrical signal to said nerve; and a controller coupled to said primary electrode (s) and controlling the first electrical signal to be applied thereby, wherein said controller is configured to cause said at least one primary electrode to apply said first electrical signal that stimulates neural activity in the pudendal nerve to improve bladder function, and wherein the first electrical signal is applied in a burst pattern.

A neurostimulation system is shown and described. The neurostimulation system may include a stimulation device implantable into a patient, a lead operatively coupled with the stimulation device, a first power cell providing power to the stimulation device where the first power cell is charged by an externally applied AC (High HF) magnetic field.

In an embodiment herein, an aortopulmonary stimulation method is provided including positioning at least one aortic electrode in or near the aorta, and using the at least one aortic electrode, to deliver stimulation to the aorta to decrease aortic after load.

A method of stimulation treatment for medical disorders using stimulation parameters that provide stimulation of a target site directly or create partial stimulation signals that combine into vector signals that stimulate a target site. Stimulation signals have characteristics such as frequency, timing, temporal content that is adjusted for the person being treated. Signals are designed with advantageous characteristics to influence target tissue in an intended manner and avoid producing unwanted side-effects. Stimulation signals are designed to match or avoid internal/endogenous activity (e.g., brain patterns and rhythms) of a patient. Methods for choosing, creating and partial signals are provided. Tissue modulation may be accomplished with electrical and/or magnetic stimulation, such as repetitive transcranial magnetic stimulation.

A neuromodulation system including at least one input module for inputting a planned neuromodulation event or a series of neuromodulation events and at least one analyzing module for analyzing a neuromodulation event or a series of neuromodulation events. The analyzing module and the input module may be connected such that the input module is configured to forward the planned neuromodulation event or a series of neuromodulation events to the analyzing module and the analyzing module is configured to analyze the planned neuromodulation event or a series of neuromodulation events regarding one or more possible neuromodulation conflict(s).

One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Methods and systems for programming stimulation parameters for an implantable medical device for neuromodulation, such as spinal cord stimulation (SCS) are disclosed. The stimulation parameters define user-configured waveforms having at least a first phase having a first polarity and a second phase having a second polarity, wherein the first and second phases are separated by an interphase interval (IPI). By delivering user-configured waveforms with different IPIs, stimulation geometry, and other waveform settings, therapeutic asynchronous activation of dorsal column fibers can be obtained.

A neurostimulation device 1 for non-destructively stimulating neural activity in a nerve 3 in proximity to a blood vessel 5. The neurostimulation device 1 comprises a catheter 7 for insertion into the blood vessel 5; a proximal electrode 11 offset from a distal electrode 9 along a length of the catheter 7; and an insulator 13 positioned between the proximal electrode 11 and the distal electrode 9 on the catheter 7. The insulator 13 has a contracted configuration in which the size of the insulator 13 allows the catheter 7 to travel inside the blood vessel 5. The insulator 13 has an expanded configuration in which the insulator 13 blocks blood flowing through the blood vessel between the proximal electrode 11 and the distal electrode 9. The neurostimulation device 1 comprises a stimulator 15 arranged to apply an electrical signal between the proximal electrode 11 and the distal electrode 9 when the insulator 13 is in the expanded configuration, thus inducing electrical activity in a wall portion of the blood vessel between the proximal and distal electrodes 9, 11. There is also an insulation portion between the distal electrode 9 and a distal end of the catheter 7 for offsetting the distal electrode 9 from a wall of the blood vessel 5.

Methods, system, and computer-implementable algorithms are disclosed for determining time-varying pulses for a patient having an implantable stimulator device (ISD). At least one time-invariant tonic stimulation pulse parameter (e.g., amplitude, pulse width, or frequency) is modified by a modulation function to produce time-varying pulses (TVPs), and one or more measurements are taken to determine the effectiveness of the TVP. The measurements may be objective and taken from the patient, and/or subjective and determined based on feedback from the patient. In one example, objective measurements may comprise one or more features determined from an electrospinogram (ESG) signal detected by the ISD, which may include evoked compound action potentials The one or more measurements are used to determine a score for the TVP, which is useful in selecting a best TVP for use with the patient, or for adjusting the modulation function applied to the tonic stimulation parameters.

Conventional devices deliver a degree of electrical charge into biological tissues; —to satisfy regulatory and safety concerns, measures are taken to maintain a zero-charge residual at the stimulation site.

Disclosed herein is a method of controlling electrical energy provided by a stimulation device to one or stimulation electrodes comprised in the device, the device including: a first stimulation electrode; a pulse energy controller for transferring electrical energy as one or more electrical stimulation pulses to the first stimulation electrode; the pulse energy controller further including two or more stimulation energy supplies for each supplying electrical energy substantially concurrently to the first stimulation electrode as a first pulse; and each supplying electrical energy separately to the first stimulation electrode as a second pulse.

A simpler, more accurate and less-expensive control of stimulation may be provided by considering each energy supply as an energy building block, which may be selected as required.