A method includes measuring, by a flow sensor (70), a flow rate of a permeate fluid (48) flowing through a filter (20) of a membrane filtration system (12). Further, the method includes receiving, by a control unit (86), the measured flow rate of the permeate fluid (48) and determining, by the control unit (86), a first flux rate of the filter (20) based on the measured flow rate of the permeate fluid (48). Furthermore, the method includes comparing, by the control unit (86), the determined first flux rate with a first predetermined flux rate. Additionally, the method includes operating the membrane filtration system (12), by the control unit (86), in a normal mode or a flux tolerant mode based on the comparison of the determined first flux rate with the first predetermined flux rate. The flux tolerant mode of the membrane filtration system (12) is further based on a determined normalized water permeability value of the filter (20).

A method includes measuring, by a flow sensor (70), a flow rate of a permeate fluid (48) flowing through a filter (20) of a membrane filtration system (12). Further, the method includes receiving, by a control unit (86), the measured flow rate of the permeate fluid (48) and determining, by the control unit (86), a first flux rate of the filter (20) based on the measured flow rate of the permeate fluid (48). Furthermore, the method includes comparing, by the control unit (86), the determined first flux rate with a first predetermined flux rate. Additionally, the method includes operating the membrane filtration system (12), by the control unit (86), in a normal mode or a flux tolerant mode based on the comparison of the determined first flux rate with the first predetermined flux rate. The flux tolerant mode of the membrane filtration system (12) is further based on a determined normalized water permeability value of the filter (20).

An electrodialysis desalination device includes a first electrode including a first-stage side; a second electrode including a first-stage side; and a first stage between the first-stage side of the first electrode and the first-stage side of the second electrode. The first stage includes at least one first-stage cell pair positioned between the first-stage side of the first electrode and the first-stage side of the second electrode, and each cell pair includes a pair of first-stage selectively permeable ion-exchange membranes with alternating selectivity that define first-stage channels on opposite sides of each first-stage membrane for respective flows of a first-stage diluate stream and a first-stage concentrate stream. A single pump is configured to pump the diluate streams and the concentrate streams through the first stage.

This present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C. The disclosure also includes a process of preparing highly concentrated antibody compositions. and highly concentrated antibody products.

A filter device includes one or more filter membranes, and a filter housing enclosing the one or more filter membranes. Each of the filter membranes includes a base membrane made of a ceramic material, and a plurality of through holes. The base membrane is coated with a coating material.

A method of filtration includes a filtration step in which a liquid to be filtered is filtered through a porous membrane module consisted of a resin having a three-dimensional network structure by external pressure filtration; a cleaning step of cleaning an outer surface of the porous membrane by carrying out backwash of passing a cleaning solution through the porous membrane from an inner surface of the membrane, and air bubbling after the filtration step; and a discharging step of discharging the cleaning solution remaining on the outer surface and inside of the porous membrane after the cleaning step; and in SEM images of a membrane cross section in a membrane thickness direction orthogonal to the inner surface of the porous membrane, a total area of a resin portion having an area of 1 μm.sup.2 or less is 70% or more relative to a total area of the resin portion.

A spiral wound assembly including a pressure vessel including an inner chamber, feed inlet, concentrate outlet and permeate outlet and a spiral wound membrane module located within the inner chamber of the pressure vessel; wherein the assembly is characterized by including: i) a flow restrictor comprising: a first and second plate in sealing contact with one another; and a fluid channel located between the first and second plate and including a first end in fluid communication with at least one of the concentrate outlet and the permeate outlet, and a second end adapted for discharging fluid from the spiral wound assembly; and ii) a sensor sheet comprising at least one sensor element located between the first and second plates and in contact with the fluid channel, wherein the sensor sheet is adapted for measuring a property of fluid passing through the fluid channel.

Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.

Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.

A gas separation system for controlling a concentration of a first gas species and a second gas species in an outlet gas comprises a splitter unit. The splitter unit comprises a gas membrane system having a gas inlet port. The gas inlet port is in fluid connection with an air intake. A membrane is a selective barrier and allows some things to pass through but stops others.