Methods of producing a deformed porous hollow fiber membrane by thermally induced phase separation, particularly by discharging a fusion kneaded product containing a thermoplastic resin and an organic liquid through an orifice of a hollow fiber-forming deformed nozzle; cooling and solidifying the fusion kneaded product discharged through the deformed nozzle to form the product into a hollow fiber-like material having a deformed cross section at a cross section vertical to a discharging direction; and extracting away the organic liquid from the hollow fiber-like material to obtain the deformed porous hollow fiber membrane, wherein an inorganic fine powder is kneaded in the fusion kneaded product.

A method of vacuum membrane filtration including placing a membrane filter between a filtration base and a pouring funnel, an upper side of the filtration base having a membrane bearing area with a bearing structure and a supporting contour surrounding the bearing structure and the supporting contour having at least one notch in flow connection with a bottom side of the membrane bearing area, detachably mounting the pouring funnel on the filtration base thereby clamping the membrane filter between the filtration base and the pouring funnel, applying suction to the filtration base such that the membrane filter is pulled against the bearing structure and comes into contact with the supporting contour, and dismounting the pouring funnel from the filtration base while still applying the suction, causing an outer rim of the membrane filter to bulge upward from the supporting contour and uncover the at least one notch.

In one embodiment, the present invention provides a central core element for a reverse osmosis separator assembly, the central core element comprising a pair of central core element components, each of said core element components comprising at least one porous exhaust conduit and at least one friction coupling, the friction couplings being configured to join said core element components to form a central core element defining a cavity configured to accommodate a first portion of a membrane stack assembly; wherein each core element component comprises a first section defining an exhaust cavity and a second section comprising a porous exhaust conduit, wherein said porous exhaust conduit comprises a removable wall member configured to form a substantial portion of a porous exhaust conduit wall.

Distributed liquid-flow systems—in which flow spreads out from a system inlet and traverses the system through multiple discrete, smaller flow channels—are constructed to minimize variations in flow-resistance-induced pressure drop from the system inlet to entrances to the flow channels. Because flow-driving pressure will be more uniform at the entrances to the flow channels, flow along the channels will be more uniform. Disclosed embodiments may be particularly suitable or advantageous for use in gas-exchange/artificial lung devices.

The present invention relates to a external-perfusion hollow-fiber membrane module containing a hollow-fiber membrane bundle including a plurality of hollow-fiber membranes; and a casing that houses the hollow-fiber membrane bundle, wherein the hollow-fiber membrane bundle has one end that is fixed to an inside of the casing by a potting portion in an open state, and the external-perfusion hollow-fiber membrane module is configured to perform degassing on a gas contained in a liquid inside the casing, the gas being introduced into an inside from an outer surface of the hollow-fiber membrane.

A process for continuous purification of high-purity trimethylaluminum is provided. The process includes preparing a membrane separator, which is placed vertically for use, and arranging a condenser tube inside of the membrane separator and a heating tube outside of the membrane separator, and a disperser at the top of the membrane separator for dispersing a liquid. The liquid naturally flows down along the inner wall of the heating tube by gravity to form a membrane. The process further includes concentrating liquid components having a low boiling point which are collected by the condenser at different stages and concentrating liquid components having a high boiling point which are collected by the heating wall.

Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (A2M) from whole blood and or recombinant A2M are provided. Also provided are methods of treating wounds with A2M. Methods for utilizing A2M in combination with other treatments (e.g., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant A2M wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of A2M and/or to prolong the half-life of the protein for treating wounds.

The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface, a heater in thermal communication with the planar surface, and a sodium sensor in electromagnetic communication with the planar surface. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.

The invention discloses a distribution plate for supplying crossflow filtration cassettes, which comprises a surface, two opposite end walls, two opposite side walls, a feed channel in fluid communication with a feed inlet port and with a plurality of feed apertures; a retentate channel in fluid communication with a retentate outlet port, and with a plurality of retentate apertures; and a permeate channel in fluid communication with two permeate outlet ports and with a plurality of permeate apertures; wherein the feed channel, the retentate channel and the permeate channel extend in a direction essentially parallel with one or both side walls; wherein the feed apertures are grouped at a first area on the surface, the retentate apertures are grouped at a second area on the surface; wherein the permeate apertures are located at the first and/or the second area; and wherein a plurality of permeate connector channels extend inside the plate from at least one region of the permeate channel, adjacent the permeate outlet ports and the permeate connector channels provide fluidic communication between the permeate apertures and the permeate channel.

Assembly for treating fluids, comprising a support (12) having a first and second oppositely arranged surfaces (121) for backing support of a semi permeable membrane (11), a first fluid conveying compartments (124) interposed between the first and second surfaces, a plurality of first fluid passages (126) extending from the first surface (121) and being in fluid communication with the first compartments (124), and a first duct attached to the support (12) and in fluid communication with the first compartments. The assembly comprises a second compartment (125) arranged for conveying fluid and different from the first compartment, and a second duct attached to the support (12) and configured to be in fluid communication with the second compartment (125).