A method of separating blood into two or more components and subsequently washing a component, comprising providing a blood storage container containing an initial blood composition, and a blood separation circuit comprising a separator. The method also comprises separating and washing cellular material within the same blood separation circuit.

A filtration arrangement for a filtration device having a container. The filtration arrangement includes at least two or more hollow shafts, rotatably mounted in a machine frame, on which a plurality of membrane filter disks are arranged. At least one drive device is allocated to the plurality of hollow shafts. Permeate can be discharged from the container through the hollow shafts. Each hollow shaft can be inserted into the container on one of the ends thereof having the plurality of membrane filter disks, such that the opposite end thereof protrudes out of the container. Several or many of the membrane filter disks are arranged axially spaced apart on each hollow shaft, and deformable spacer sleeves are arranged between one part or all adjacent membrane filter disks and axially space apart the membrane filter disks on the hollow shafts.

A filtration arrangement for a filtration device having a container is provided. The filtration arrangement includes at least two hollow shafts rotatably mounted in a machine frame and on which a plurality of membrane filter disks are arranged. The at least one or the plurality of hollow shafts being assigned at least one drive device, the discharge of permeate from the container being possible through the hollow shafts, and it being possible to insert each hollow shaft at one of its ends with the plurality of membrane filter disks into the container, such that its opposite end projects out of the container. A rotatable pump disk, which forms part of a centrifugal pump arrangement for pumping permeate, is arranged or formed at the opposite end of each rotatable hollow shaft.

A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

A system for remedying deep-sea mine tailings includes a reaction basin in which the solid-liquid ratio of deep-sea mine tailings is adjusted and into which aluminum sulfate is injected as an additive for extraction of heavy metals from the deep-sea mine tailings.

The invention relates to a method for the purification of immunoglobulin and/or albumin from a sample of plasma, the method comprising mixing a sample of plasma with a medium chain fatty acid, and recovering the soluble immunoglobulin from the mixture.

A well plate includes a including a top portion, a bottom portion and a membrane disposed between the top portion and the bottom portion. The top portion defines a sample well in fluid communication with an opening defined by the membrane and in fluid communication with a reservoir defined by the bottom portion. The well plate is configured to be used in a centrifugation process of a test sample including a sample material and a wash liquid. The test sample configured to be received within the sample well and the reservoir. The membrane configured to filter the wash liquid from the test sample during the centrifugation process such that the wash liquid can pass from the reservoir, through the membrane and can be captured within a collection chamber while the sample material remains within the reservoir.

A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.

Methods for controlling a spinning membrane separator so as to limit fouling of the membrane by changing the rotation rate of the spinning membrane in response to the fouling rate, while maintaining a constant outlet cellular concentration. Increasing the spinner rotation rate will increase the strength of the Taylor vortices generated within the separator by the spinning of the membrane, which should reduce fouling of the membrane. The goal of the method is to rotate the spinning membrane at the slowest rate possible without unacceptable fouling. Two specific methods to control fouling are disclosed. In a first, unidirectional method, the spin rate of the membrane is only increased in response to undesirable fouling in order to prevent the fouling from continuing. In a second, bidirectional method, the spin rate of the membrane may be either increased or decreased in response to the measured fouling rate in order to maintain the fouling rate within a desired range.

This invention relates generally to a filtration process and apparatus for separating valuable or harmful process liquids from mixtures or slurries that contain such liquids and solid particles. In particular, the invention relates to a filtration process for separating Process Liquid from a feed slurry that comprises a mixture of the Process Liquid and solid particles, the process employing a Sweep Liquid that is less dense than the Process Liquid.