Disclosed herein are apparatuses and methods for semi-permeable membrane cleaning. Specifically, a pressure retarded osmosis (PRO) process redirects raw solution and fluid streams in such a way as to cause periodic changes of the process from PRO to reverse osmosis (RO) for removing fouling. Further disclosed is applying a pulsed-flow regime in the fluid stream, thereby causing increased shearing force for enhanced foulant evacuation. Additionally, a backward wash may be provided by injection of additional solution such that net driving pressure becomes RO as opposed to PRO, thereby providing a backward flow from a first side of the membrane to a second side. Further disclosed are phased operations that resolve the issue of self-extinguishing PRO, thereby providing energy savings and/or PRO process optimization by, for instance, (1) utilizing osmotic pressure for circulation, (2) variation in POp gauge pressure, and/or (3) variation of the ratio of Additional Solution to Draw Solution.

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

Methods include monitoring blood pH or electrolyte levels and setting initial fluid parameters, such as dialysate fluid parameters or replacement fluid parameters, for a blood fluid removal session based the monitored data. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.

A water purifier, including a housing, a piston cylinder, a base, and a dust cap. The housing includes a water inlet end and a water outlet end, and a composite filter material and an ultrafiltration membrane are disposed in the housing to constitute a filter element. The piston cylinder is sleeved on the housing. The upper end of the piston cylinder is provided with a suction nozzle. The base includes an upper part and a lower part. The upper part includes a lower bayonet and an upper bayonet. The lower part includes a multipurpose interface and a water inlet nozzle. The dust cap is disposed on the upper end and covers the suction nozzle. The central part of the dust cap protrudes downward to form a flexible sealing plug. The water inlet end of the housing is secured to the lower bayonet of the base.

A method includes monitoring an indicator of fluid volume of a patient via a sensor device, and setting an initial fluid volume removal prescription for a blood fluid removal session based on the monitored indicator of fluid volume. The method may further include transmitting data regarding the indicator of fluid volume from the implantable sensor device to fluid removal device. The system includes a blood fluid removal device configured to set the initial fluid removal volume and rate prescription. In some embodiments, the fluid removal device sets or calculated the initial fluid volume removal prescription based on the data received from the implantable sensor. The indicator of fluid volume may be an indicator of tissue fluid volume or an indicator of blood fluid volume.

Disclosed herein is a water purifying system, including: a raw water tank configured to store raw water; a filter unit configured to include a plurality of filtration modules for purifying the raw water and a plurality of valves for feeding or cutting off the raw water; a raw water pump configured to feed the raw water from the raw water tank to the filter unit; and a backwash module configured to feed backwash water to the filter unit, in which some of permeate water permeated by the filter unit is fed to the backwash module to be used as the backwash water and a feed pressure of the backwash water is fed by the raw water pump.

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

A method includes initiating a blood fluid removal session of a patient; monitoring an indicator of tissue fluid volume of the patient, or a portion thereof, during the blood fluid removal session; monitoring an indicator of blood fluid volume of the patient during the blood fluid removal session; determining whether a ratio of the indicator of tissue fluid volume to indicator of blood fluid volume is outside of a predetermined range; and altering the rate of fluid removal during the blood fluid removal session if the ratio is determined to be outside of the predetermined range. A blood fluid removal system may be configured to carry out the method.

A membrane filtration device includes a plurality of membrane separation units vertically disposed in multiple stages. The membrane separation unit has a primary side communicating with a backwash drainage system and a flushing-air supply system to receive supplied raw water and a secondary side communicating with a backwash-water supply system to collect permeate. The backwash-water supply system includes a backwash-water main pipe and a plurality of backwash-water branch pipes to feed the backwash water into the membrane separation units. The backwash drainage system includes a plurality of backwash-drainage branch pipes and a backwash-drainage main pipe connected in parallel to the backwash-drainage branch pipes. The flushing-air supply system includes an air main pipe for passing flushing air upward and a plurality of air branch pipes for feeding flushing air into the membrane separation units, the air branch pipes being connected in parallel to the air main pipe.