The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.

A device (1) for mixing which comprises a housing (2) with at least one inlet (3). A first process region (4) mixes the supplied substances which are introduced via the inlet (3) while a second process region (5) discharges the mixture via an outlet (6). A first gap-forming element (7), preferably a rotor, is assigned to the first process region (4) and comprises openings (8), and a second gap-forming element (9), preferably a stator, is assigned to the second process region (5) and corresponds with the first gap-forming element (7), wherein the second gap-forming element (9) comprises openings (10). At least one of the gap-forming elements (7, 9) is rotatable relative to the other gap-forming element (7, 9). The openings (8, 10) of the first and second gap-forming elements (7, 9) are arranged such that a mixture passes through the openings from the first into the second process region.

The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Disclosed herein are formulations and processes for the preparation of pigment and wax dual dispersions by (1) providing a solution comprising a water and at least one surfactant in a dispersion apparatus comprising a container, a rotor-stator homogenizer, and a piston homogenizer coupled via a recirculation device; (2) adding at least one pigment to the solution; (3) forming a pigment dispersion by flowing the at least one pigment and the solution to the rotor-stator homogenizer via the recirculation device; (4) adding at least one wax to the pigment dispersion; and (5) flowing the at least one wax and pigment dispersion to the piston homogenizer via the recirculation device until a pigment and wax dual dispersion is formed. Also disclosed herein are pigment and wax dual dispersions, as well as a dispersion apparatus for preparing pigment and wax dual dispersions. In certain embodiments, a dispersion apparatus for preparing a pigment and wax dual dispersion may comprise a container, a rotor-stator homogenizer, a piston homogenizer, and a recirculation device coupled to the container and the homogenizers that allows a dispersion to flow between the container and the homogenizers.

An emulsion system is provided. The system includes a shaft that supports a plurality of cutting assemblies and plates in alternating order, wherein the cutting assembly rotates with respect to an in close proximity to the plate. The plurality of cutting plates each on their circumferential edge have an identification system to memorialize the diameter of the emulsion holes.

The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.