A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm.

A device and method for processing solid cleaning product into solution. A drum has a plurality of canisters. Each canister has a top opening and a lower opening. A plate is positioned below the drum. The plate has an orifice therein. The drum and lower plate are in a rotational relationship to progressively align the lower opening of each canister with the orifice in the plate. A mixing tank is positioned below the drum. The mixing tank receives a sleeve of solid cleaning product gravitationally transported from a canister of the drum through the orifice of the lower plate.

The solid cleaning product is mixed with water in the mixing tank. After mixing, the resulting cleaning solution is transported to a holding tank. The process is repeated according to the level of cleaning solution in the holding tank.

The invention provides a method for producing prion protein having an aggregated conformation by contacting native conformation prion protein with aggregated conformation prion protein in a liquid preparation and subjecting this to at least one cycle or to a number of cycles of application of shear-force for fragmenting aggregates of prion protein, wherein the shear-force applied is precisely controlled. In addition to this process for amplification of aggregated state prion protein from native conformation prion protein, the invention relates to the aggregated state prion protein obtained by the amplification process, which aggregated state prion protein has one conformation, which is e.g. identical within one batch and reproducible between batches, e.g. as detectable by proteinase resistance in a Western blot.

A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm.

A mixer support assembly for use in an integrated cover and mixer apparatus and anaerobic digester system incorporating same provided. The digester system includes a tank with an integrated cover and mixer apparatus which provides a completely or substantially gas tight enclosure for the collection of biogas. The integrated cover and mixer apparatus includes a cover, a mixer, and a mixer support assembly for supporting the mixer. The mixer support assembly includes a float ring and a support body that is selectively removable from the float ring. The support body is attached to the float ring by way of a clamping arrangement.

A mixing machine includes a mixing head and at least one connection means for connecting a mixing container containing material to be mixed to said mixing head for forming a closed mixing container. The mixing head, as part of a pivotable assembly, is pivotably mounted with respect to a frame such that the closed mixing container formed from the mixing head and the mixing container can be pivoted relative to the frame for performing the mixing process. The mixing head carries at least one rotationally-driven mixing tool. The mixing head comprises a head plate having a connecting flange molded thereon which is configured as an annular disc and comprises a planar contact surface. At least two ring seals of differing diameters are arranged in said contact surface of the connecting flange at a spacing between each other, such that mixing containers with different connection diameters of their mixing head side can be connected to said mixing head. The at least one connection means is configured for gripping mixing containers which differ in the diameter of their connection sides.

A mixer apparatus for mixing high viscosity fluids has a mixer shaft with a plurality of sets of blades affixed thereto. A lowermost set of blades is pivotally mounted so as to be movable between a first position pivoted upwardly and a second position pivoted outwardly. The mixer apparatus has a hydraulic motor drivingly connected to the mixer said shaft so as to rotate the mixer shaft, a hydraulic pump connected by fluid circuit to the hydraulic motor, and electric motor connected to the hydraulic pump, and a hydraulic fluid reservoir connected to the fluid circuit so as to supply hydraulic fluid to the hydraulic pump. The mixer shaft has a base at the lowermost end thereof.

A mixer apparatus for mixing a high-viscosity fluid has a mixer shaft with a plurality of blades affixed thereto, a hydraulic motor drivingly connected to the mixer shaft so as to rotate the mixer shaft, a hydraulic pump connected by a fluid circuit to the hydraulic motor so as to deliver hydraulic fluid under pressure to the hydraulic motor, an electric motor drivingly connected to the hydraulic pump, and a hydraulic fluid reservoir connected to the fluid circuit so as to supply hydraulic fluid to the hydraulic pump. The plurality of blades are pivotally mounted to the mixer shaft.

A mixing system typically for use in a container for mixing its contents, the mixing system including a cap unit, an extension unit and a magnetic mixing unit that is attached to the cap unit by the extension unit. The magnetic mixing unit can be folded to permit insertion and/or removal of the system via a mouth of the container. The extension unit and magnetic mixing unit connect via a hinge formed by upper and lower hinge portions that meet at a pivot point. The hinge portions extend from the pivot point along a first axis. The magnetic mixing unit includes a first magnetic elongate member that extends from the lower hinge portion along a second axis that is substantially perpendicular to the first axis, and a second magnetic elongate member that extends from the lower hinge portion along the second axis in the opposite direction relative to the first elongate member. The magnetic member(s) may be provided by a plastic coated magnetic stir bar.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.