Method of robot control is disclosed that includes the steps of: providing a user interface for introducing data indicative of a drug to be subjected to a reconstitution process; accessing an internal data base for outputting, for a selected drug, a list of primitive movements P1, P2, . . . Pi, . . . Pn to be used in the reconstructing process; operating the robot for executing sequentially the primitives and moving a container according to the instructions of the primitives; measuring, during the movement of the container under robot action, physical positions in the space and dynamic parameters of the container creating a list of registered data; comparing the measured positions in the space and the dynamic parameter with the corresponding ones of the primitive movements for selecting a list of eligible primitives if a sufficient approximation level is reached; elaborating selected eligible primitives together to generate instructions for the robot allowing a complex movement encompassing the simple movements; and using the robot for shaking the container according to the complex movement.

The invention comprises a novel modular, generalizable meso-micro-nano-fluidic platform apparatus, design and methodology which in exemplary embodiments may be applied in conjunction with a novel external triggering and automation/feedback loop control mechanism deployed via computer to explore the phase space of single or double emulsification for applications including the encapsulation of hydrophilic active pharmacological ingredients (APIs). End use applications include the mass production of particulate encapsulation of hydrophobic or hydrophilic APIs with automatic or user-supervised feedback methodology to control and discover mass production or per-drug customized settings of interest for the manufacture of novel or extant therapeutics. This invention allows for a process to produce monodispersed particles of varying sizes and may be used to rapidly screen for optimal size for maximal bioavailability of API particles either on lab bench for in vitro dissolution or in vivo studies, and patient-specific handhelds for maximal drug inhalation.

Provided is a liquid medication dispensing machine that can shorten the time to supply a liquid medication to a prescription bottle. The liquid medication dispensing machine is a liquid medication dispensing machine supplying a liquid medication from a liquid medication bottle containing the liquid medication to a prescription bottle, including a liquid medication stirring unit that stirs the liquid medication in the liquid medication bottle, a bottle holding unit that holds a plurality of liquid medication bottles including a first bottle containing a liquid medication G and a second bottle containing a liquid medication B, and a control unit that controls operation of the liquid medication dispensing machine. The control unit operates the liquid medication stirring unit to stir liquid medication B while liquid medication G is supplied from the first bottle to the prescription bottle.

The present disclosure provides for a first embodiment, where, a first, lower shaft speed mixing of the component combination takes place in a thermokinetic mixer, where monitoring of the batch by temperature rate increase determination results in a determination that a substantial portion of desired thermokinetic mixing has occurred, whereafter a different shaft speed is used to complete the desired thermokinetic mixing of the component combination.

Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.

A molded product production system includes at least two measuring feeders configured to simultaneously adjust an amount of a discharged powdery material to a target value and feed the powdery material, a mixer configured to mix at least two powdery materials fed from the measuring feeders to obtain mixed powdery materials, a filler configured to fill, with the mixed powdery materials obtained by the mixer, a die bore of a compression-molding machine configured to compress a powdery material to mold a molded product, a sensor configured to measure a mixing degree of the mixed powdery materials obtained by the mixer, and a controller configured to adjust an amount of at least one of the powdery materials fed by the measuring feeders, or motion speed of a mixing member configured to agitate powdery materials in the mixer in accordance with the mixing degree of the mixed powdery materials measured by the sensor.

A molded product production system includes a powdery material mixing and feeding device configured to feed mixed powdery materials including at least two types of powdery materials, a filler configured to fill, with the mixed powdery materials fed by the powdery material mixing and feeding device, a die bore of a compression-molding machine, a sensor configured to measure a mixing degree of the mixed powdery materials fed by the powdery material mixing and feeding device, and a molded product removal mechanism configured to distinguish a molded product obtained by compression molding mixed powdery materials having a mixing degree measured by the sensor out of a predetermined range from a molded product obtained by compression molding mixed powdery materials having a mixing degree within the predetermined range.

An integrated medicine mixing interface comprising a medicine mixing mouth (1), hard double interfaces (2) and a medicine feed needle (3). The hard double interfaces (2) comprise a base (21), a medicine mixing interface (22) and an infusion interface (23). The medicine mixing mouth (1) and the medicine mixing interface (22) are integrated. When using the integrated medicine mixing interface, it is only necessary to weld the base (21) to the bag body of a soft infusion bag (11) and integrate the medicine mixing mouth (1) with the medicine mixing interface on the hard double interfaces (2) without adopting a hose connection and an easily folding handle, which not only reduces hose installation location, but also avoids welding leakage brought about by hose welding defects. Moreover, the structure is simple and the costs are low.

Systems and method for producing a small-scale mixer are provided. In some implementations, a method for includes obtaining dimensions of an at-scale mixer. The method also includes determining first dimensions of the small-scale mixer based on respective dimensions of the at-scale mixer. The method further includes determining second dimensions of the small-scale mixer independent of the dimensions of the at-scale mixer. Additionally, the method includes generating the small-scale mixer using the first dimensions and the second dimensions using a three-dimensional printer.

Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.