A device for non intrusive agitation of a fluid is provided, including a container adapted to contain the fluid, at least one of the walls thereof includes a membrane and a main movable stirring means inside the container adapted to stir at least the fluid. The first flexible element is adapted to interfere mechanically with an external movable impulsion means, thus creating a deformation which has a mechanical interference with the main movable stirring means. This movement of such impulsion means is transmitted to the main movable stirring means by the interposition of the first flexible element.

A packaging for a flexible container, in particular for a disposable bag for use in a bioreactor, comprises a bottom part for fixing a first portion of the container, a ceiling part for fixing an opposite second portion of the container, a receiving space which on a first side is defined by the bottom part and on an opposite second side is defined by the ceiling part, and struts arranged between the bottom part and the ceiling part, which fix a defined distance between the bottom part and the ceiling part.

A method for operating a bioreactor includes passing a drive shaft into a first tubular connector and a second tubular connector projecting from the first tubular connector, the first tubular connector and the second tubular connector being at least partially disposed within a container, the first tubular connector being more flexible than the second tubular connector, the second tubular connector having a length that comprises at least 20% of a combined length of the first tubular connector and the second tubular connector. Rotating the drive shaft so as to rotate the first tubular connector and the second tubular connector within the container.

An incubation device has multiple rocking platforms with each platform pivotally mounted about a respective axis. Each rocking platform has a respective receiving device for mechanically reversibly receiving a respective incubation channel. The device also has a common drive unit for common respective rocking movements of each platform from a zero position through with a specific angle range as a result of movement of the drive unit. Each rocking platform is coupled to the drive unit via a respective coupling mechanism, and each coupling mechanism elastically and resiliently couples the respective rocking platform to the drive unit, such that when the rocking platform is restrained, despite continuation of the drive movement, the rocking platform remains motionless in a fixed position. After release of the restraint on the rocking platform, the rocking platform resumes the rocking movement with the specific angle range.

In accordance with embodiments of the herein disclosed subject matter it is described a stirring device (100) comprising a shaft rotatable about an axis of rotation; a stirring element (106) attached to the shaft, the stirring element (106) having a recess (108); the recess (108) having a surface portion (114) and an edge (116), the edge (116) defining an opening which provides access to the surface portion (114); the recess (108) being spaced from the shaft, wherein a rotation of the shaft defines a moving direction (120) of the recess (108) in which the edge (116) forms a leading edge of the recess (108); the surface portion (114) defining a depth (122) of the recess (108) with regard to the edge (116); and wherein in a direction (124) radially inwardly the depth (122) of the recess (108) is decreasing. In accordance with embodiments, the decreasing depth (122) may be realized by a suitable inclination (136) of the surface portion (114) of the recess (116) and/or by a suitable inclination (140) of the edge (116) of the recess (108).

A mixing system includes a container having a support plate and a mixing assembly supported on the support plate. The mixing assembly includes a pliable enclosure containing a fluid and a mixing device. A portion of the mixing device extends from the pliable enclosure and is adapted to be detachably coupled to a drive mechanism. A first plate is detachably secured to the rigid container. The pliable enclosure is disposed between the first plate and the support plate. A mixing arrangement includes a docking station having a drive cradle and a drive mechanism. The mixing system is removably positioned within the drive cradle so that the drive mechanism is removably coupled to the mixing device.

A method for producing a liquid medium composition, including mixing a first liquid A1 containing a particular compound and a second liquid B1 containing a linking substance, and the method is carried out using a production apparatus. The production apparatus has a container 1 provided with at least two openings 2, 3 in a wall, the two openings are connected to each other by a tube 4 outside the container, and the tube has a part with a shape and flexibility that render the tube placeable as a pumping tube into a peristaltic pump 5. In the production method, the peristaltic pump is operated, and the first liquid and the second liquid are mixed by circulating them to form the object liquid medium composition in the container.

The present invention relates to a bioreactor assembly comprising a plurality of trays (30) for holding a cell culture bag, a holder (2) on which the trays are mounted side by side to form a first series of trays rocking mechanism (4) for rocking the trays, the rocking mechanism (4) being operatively connected to each of the trays (30).

The invention also relates to a bioreactor system (100) comprising at least one bioreactor assembly.

A stirring device of a plug-flow fermentation device includes a shaft rotatable about an axis of rotation which defines an axial direction. The stirring device further includes a boundary stirring element that defines the axial extent of a stirring volume covered by the stirring device. A nearest neighbor of the boundary stirring element in the axial direction has an axial maximum width which is smaller than an axial maximum width of the boundary stirring element and which is larger than an axial maximum width of a next-nearest neighbor of the boundary stirring element.

It is an object of the present technology to provide a sample liquid accommodation container that has favorable dispersibility of microparticles in a sample liquid when the sample liquid is stirred and allows the sample liquid to be easily taken out.

The present technology provides a sample liquid accommodation container including: a container main body that has a bottomed cylindrical shape with an opening at one end and a bottom surface portion at another end, and accommodates a sample liquid containing microparticles; and a lid body that has a top surface portion and seals the opening of the container main body, in which the top surface portion of the lid body has a first through hole, and an inner surface of the top surface portion of the lid body has an inclined surface inclined upward with the first through hole as a highest point.