The invention relates to a sealed container (1) comprising a flexible film (2) which is arranged to define an internal space (3) and a through-opening, and a sealed connection device (4) which is arranged to allow the flexible film (2) to be connected to a complementary connection device of a sterile enclosure, while ensuring sterile communication between the internal space (3) of the container (1) and that of the enclosure, the connection device (4) comprising a flange to which the flexible film (2) is attached, the flange delimiting the through-opening of the flexible film (2), characterized in that the flange is constituted by two different pieces distinct from each other, respectively forming an external sleeve (5) and an internal sleeve (6) the flexible film (2) being kept gripped between the external sleeve (5) and the internal sleeve (6).

A method for transferring at least one filling needle of a number of filling needles into an isolator which has a transfer lock, the method having the following steps: providing a first needle carrier within the transfer lock, said needle carrier carrying the number of filling needles; providing a second needle carrier in a first position within the isolator; robot-assisted transferring of the at least one filling needle of the number of filling needles from the first needle carrier to the second needle carrier; and robot-assisted placing of the at least one filling needle of the number of filling needles in the second needle carrier, wherein the at least one filling needle of the number of filling needles is held directly during the robot-assisted placing. A transfer system, in which such a method can be conducted, is also disclosed.

A system for measuring electrical characteristics of bioparticles is described. The system comprises an incubator for performing electrochemical measurements in a defined environment and a substrate holder positioned in said incubator for holding a substrate comprising a plurality of wells. The system is furthermore configured for continuously or regularly measuring electrochemical data. The system also comprises a processing means for comparing the continuously or regularly measured electrochemical data with reference data and for determining a moment for adding an active compound based on said comparison.

The invention relates to a sealed transfer device between two enclosed volumes, comprising two flanges (10, 20) that can be secured to each other by a first bayonet connection, two doors (11, 21) which close off the passage openings defined by the flanges and can be secured to each other by a second bayonet connection, and a control mechanism comprising a control member (3) that is movably mounted on the first flange (10) between a closed position and an open position of the doors (11, 21), characterized in that the control mechanism comprises a member (7) for locking the second door (21) to the first door (11), ensuring that the doors are locked together when the control member (3) switches into the open position of the first and second doors, said locking member (7) being integrated into the first door (11).

The invention relates to a sealed transfer device between two enclosed volumes, comprising two flanges (10, 20) that can be secured to each other by a first bayonet connection, two doors (11, 21) which close off the passage openings defined by the flanges and can be secured to each other by a second bayonet connection, and a control mechanism comprising a control member (3) that is movably mounted on the first flange (10) between a closed position and an open position of the doors (11, 21), characterized in that the control mechanism comprises a member (7) for locking the second door (21) to the first door (11), ensuring that the doors are locked together when the control member (3) switches into the open position of the first and second doors, said locking member (7) being integrated into the first door (11).

Device for testing sealing of at least a part of a double-door sealed transfer system between two closed volumes, the system including a first flange and a and a second flange capable of being rigidly connected to one another, and a first door and a second door normally sealing openings respectively defined by the first and the second flanges, the device including a casing including a cavity provided with an opening, mechanical connection to a flange so that the cavity is closed by the flange and the door and an inflatable joint which, in the inflated state, is in contact with the flange and ensures a sealing allowing to verify the sealing between the flange and the door.

Device for testing sealing of at least a part of a double-door sealed transfer system between two closed volumes, the system including a first flange and a and a second flange capable of being rigidly connected to one another, and a first door and a second door normally sealing openings respectively defined by the first and the second flanges, the device including a casing including a cavity provided with an opening, mechanical connection to a flange so that the cavity is closed by the flange and the door and an inflatable joint which, in the inflated state, is in contact with the flange and ensures a sealing allowing to verify the sealing between the flange and the door.

The invention relates to a sealed container (1) comprising a container body (2) having a through-hole (8) that is delimited by a flange and is closed by a removable door (7) mounted on the flange, an annular seal (13) located between the flange and the door (7), the flange, the door (7) and the seal forming a sealed connection device that can be connected to a complementary connection device on a sterile enclosure by means of bayonet connection means in order to allow sterile communication between the sealed container and the sterile enclosure, characterized in that the seal (13) comprises, on its inner peripheral circumference, an annular attachment bead (130) for attaching the door (7) to the flange inserted into a notch (70) on the door (7).

The present invention relates to a biological (eg cell) processing assembly comprising an aseptic chamber with apertures adapted for gloves to fit and an incubation chamber connectable to aseptic chamber with transfer hatches, doors secured by multi-walls and inflatable seals, stepped collars for tight closure of doors and closed interaction between the chambers. From the aseptic chamber it can be reached through into incubation chamber. There is a docking spigot on outlet wall to interact with stepped collar to define transfer port between the chambers and a disinfectant delivery device to disinfect transfer port.

The present invention relates to a biological (eg cell) processing assembly comprising an aseptic chamber with apertures adapted for gloves to fit and an incubation chamber connectable to aseptic chamber with transfer hatches, doors secured by multi-walls and inflatable seals, stepped collars for tight closure of doors and closed interaction between the chambers. From the aseptic chamber it can be reached through into incubation chamber. There is a docking spigot on outlet wall to interact with stepped collar to define transfer port between the chambers and a disinfectant delivery device to disinfect transfer port.