The present disclosure relates to a holder for releasably coupling at least one external medical module, for example a blood filter, to a medical treatment apparatus, wherein the holder comprises at least a first reception unit and a second reception unit.

Embodiments disclosed herein are directed to microfluidic devices that allow for scalable on-chip screening of combinatorial libraries and methods of use thereof. Droplets comprising individual molecular species to be screened are loaded onto the microfluidic device. The droplets are labeled by methods known in the art, including but not limited to barcoding, such that the molecular species in each droplet can be uniquely identified. The device randomly sorts the droplets into individual microwells of an array of microwells designed to hold a certain number of individual droplets in order to derive combinations of the various molecular species. The paired droplets are then merged in parallel to form merged droplets in each microwell, thereby avoiding issues associated with single stream merging. Each microwell is then scanned, e.g., using microscopy, such as high content imaging microscopy, to detect the optical labels, thereby identifying the combination of molecular species in each microwell.

Disclosed herein are flask clamps that capture and firmly hold flasks or vessels of various shapes, enclosing the sidewall of the flask or vessel in a trap or loops. The trap relatively conforms to the profile of the perimeter of the vessel and are spring loaded in the upward direction in order to rise upward along the sides of the vessel. The loops pivot relative to the bottom of the flask creating an arc motion that tightens against the sidewall as it rises. The loaded loops are in tension against the flask, and the multiplicity of loops hold vessels in tension with opposing forces.

A connector for flexible tubing comprises a first hollow insert for allowing fluid flow, having a proximal end configured to fit inside the tubing, a first outer part, a joining member rigidly connecting the first insert to the outer part at a region spaced from the proximal end of the first insert and a generally annular gap between the first insert and the first outer part, which forms a tubing accepting opening at or adjacent the proximal end of the insert, the first outer part further comprising plural resilient protrusions extending into the gap, allowing the tubing to be inserted, but resisting removal of the tubing once inserted and wherein at least the insert, the joining member and the outer part are formed as a single integral molding.

The present disclosure provides methods and apparatus for reducing bubble formation during incubation processes. The incubation process, e.g., a hybridization process for a hybridization solution, can be more than a few hours, during which there are bubbles formed at the end of the incubation process. The present disclosure provides a hybridization method with reduced bubble formation at the end of the hybridization process.

A clamping platform for a mechanical shaker, which allows automated release and fastening of microtiter plates that are subject to tolerances, includes at least two mounts arranged pairwise for the releasable fastening of the microtiter plates. The platform includes clamping jaws, on which a compression spring acts, actuatable with a link control having a linear drive. In conjunction with the compression spring, the geometry of the guide links allows compensation for the dimensional tolerances of the microtiter plates that are to be fixed by clamping. The spring force of the compression spring is determined such that the clamping jaws that are loaded by the compression spring exert the required clamping force in the deployed position onto the microtiter plates to be fixed.

This disclosure is directed to an apparatus, system and method for retrieving target material from a suspension. A system includes a processing vessel, a displacement fluid, and a tube. The tube includes a funnel, a cannula, and a cavity. The cannula allows for fluid communication between the funnel and the cavity, such that the processing vessel is inserted into the cavity, and the cannula extends into the processing vessel.

Provided are automated cell culture systems and related in vitro cell culture methods, including for a co-culture of different cell populations having different cell culture conditions. For example, the system may comprise a bioreactor having a plurality of cell culture compartments, the bioreactor having a fluid port fluidly connected to the plurality of cell culture compartments. A pump fluidly connected to the fluid port can provide a cell culture medium to the plurality of culture compartments. A sensor is operably connected to at least one of the plurality of cell culture compartments for measuring at least one cell culture parameter. In this manner, a controller electronically connected the pump and sensor, is configured to automatically adjust a pump flow rate and/or a cell culture gas content to provide a desired steady-state cell culture parameter for facilitating cells interactions and collection of products representative of said interactions.

A sample receptacle transporting carrier includes a base defining a recess for receiving a bottom end of the sample receptacle. The carrier also includes a plurality of resilient wire fingers affixed to and extending upward from the annular support. The fingers are configured to retain the bottom end of the sample receptacle within the recess of the base and to maintain the sample receptacle in an upright orientation. Each of the wire fingers includes a first segment adjacent to the base, a linear second segment joined to the first segment by a first angled portion, and a linear third segment joined to the second linear segment by a second angled portion. The third segment of each finger is configured to contact the bottom end of the receptacle as the receptacle is inserted into the carrier. The third segment and the vertical axis of the carrier form an angle between about 40 and about 50.

The present disclosure provides a frozen sample holder having an identification ring, and relates to the technical field of freezing sectioning-related equipment, the frozen sample holder having an identification ring comprising an identification ring structure and a frozen sample holder structure, wherein the identification ring structure is in connection with an outer wall of the frozen sample holder structure; and the identification ring structure includes an identification segment, which is configured to mark the information of a sample in the frozen sample holder structure. The present disclosure solves the technical problem existing in the operating process of freezing sectioning all along that multiple samples would easily be confused with each other due to the difficulty to mark frozen sample holders.