Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

An inspection chip according to the present invention is an inspection chip for stirring liquid by a circular movement of a bottom surface end, including a well main body for accommodating the liquid and a side wall member arranged on a side surface of the well main body. The bottom surface end has a bottom surface structure in contact with a rotating member for allowing the bottom surface end to perform the circular movement in a position leaning from a center line of the well main body toward the side wall member.

Methods of partition-based analysis. In an exemplary method, a device having a port fluidically connected to a chamber may be selected. A sample-containing fluid may be placed into the port. The sample-containing fluid may be moved from the port to the chamber. Partitions of the sample-containing fluid may be formed. A monolayer of the partitions in the chamber may be created. At least a portion of the monolayer may be imaged.

Machine image detection involving a trained classifier is used to detect a result of a test stick diagnostic device configured to detect the presence of an analyte in a test sample. Example implementations include receiving a digital image comprising a depiction of at least a portion of a test stick diagnostic device and applying the digital image to a classifier configured to determine a relative position, relative orientation, and relative scale of the portion of the test stick diagnostic device with respect to the digital image, identify a test result region of the test stick diagnostic device, and detect a test result marking in the test result region of the test stick diagnostic device. An indication of a result of a diagnostic test may be provided based on the detected test result marking.

Instruments, systems, and methods for measuring optical density of microbiological samples are provided. In particular, optical density instruments providing improved safety, efficiency, comfort, and convenience are provided. Such optical density instruments include a handheld portion and a base station. The optical density instruments may be used in systems and methods for measuring optical density of biological samples.

An add-on device for attachment to a micropipette for determining the rotational movement and longitudinal displacement of a micropipette plunger for digitization, communication and quantification of pipetting actions.

An automatic assaying system having a multiplex pipette cartridge section in which pipette cartridges are docked. At least one pipette cartridge has a different pipetting characteristic from another corresponding pipette cartridge, the different pipetting characteristic being selectable from a number of different pipetting characteristics. A multiplexing work item holder has an array of work item holder docks that dock corresponding work item holders selectable from pipette trays and pipette tip set racks that define the selectable different pipetting characteristic. One or more of the work item holder docks are indexed to selectably multiplex both the different interchangeable pipette trays and the at least one pipette set rack. A carrier moves the pipette cartridge or a work item holder carriage and a controller selects the at least one pipette tip set rack corresponding to a work item holder dock so as to effect automatic selection of the different pipetting characteristic.

The present invention relates to the field of droplet microfluidics, particularly relates to a droplet sorting chip. The droplet sorting chip disclosed herein is provided with a cavity area, which can accommodate impurities such as fibers entering the droplet sorting chip, can effectively prevent clogging and collision and fusion of droplets caused by impurities, and ensure smooth droplet sorting.

Arrays of droplet-on-demand dispensers are controlled by a row-column addressing scheme that can reduce the number of on-chip address lines, thereby making it feasible to construct large dispenser arrays. Decoders are used to further reduce the number of control lines that select a specific address line. A microfluidic logic controller includes row-select lines, each coupled to dispensers disposed on the same row, and column-select lines, each coupled to dispensers disposed on the same column such that each dispenser is associated with a unique row-column address. A logic circuit can actuate a dispenser only if the logic circuit receives signals from both of the row-select line and the column-select line corresponding to the row-column address of the selected dispenser. Reagents can be dispensed from the dispenser array, thereby allowing for rapid formatting of a reagent library into microfluidic droplets.

A pipetter is disclosed that has a suction lumen with an opening and an ejection bar that slides relative to the suction lumen. The pipette tip has a distal end opening and a proximal end with a rim. The pipette tip has a pipette wall with a low-force stretch region with a plurality of thinning channels. The system comprises at least three configurations: an insertion configuration, wherein (1) the suction lumen is inserted into the proximal opening, and (2) the ejection bar does not abut the rim; a sealed/installed configuration, wherein (1) the suction lumen forms a liquid-tight seal between the suction lumen and the pipette wall, and (2) the ejection bar abuts the rim, preventing further insertion of the suction lumen (95); and an ejection configuration, wherein (1) the ejection bar is slid towards the rim, and (2) the ejection bar dislodges the pipette tip from the suction lumen.