Systems for performing cellular analysis and related devices for conditioning environments adjacent chips in such systems. A device for conditioning an environment adjacent a chip in a system for performing cellular analysis, the device includes a cover for being disposed adjacent the chip and comprising a planar body having a top surface, a bottom surface, and an outer edge surface. The cover includes a central opening extending between the top surface and the bottom surface and bounded by an inner edge surface of the cover. The cover also includes a fluid inlet extending into the body from the outer edge surface between the top surface and the bottom surface the fluid inlet arranged to accept a gas to be delivered to the central opening. The cover also includes a plurality of fluid outlets defined in the inner edge surface and in fluid communication with the fluid inlet. The plurality of fluid outlets are arranged to receive the gas from the fluid inlet and exhaust the gas into the central opening.

In certain embodiments, the disclosure provides an inflatable bladder lid that configures with a cartridge configured for assay testing. The inflatable bladder provides substantially uniform pressure to the cartridge. The pressure is substantially distributed across the one or more regions of the cartridge to extend pressure over a wide cartridge surface. At least a portion of the bladder lid may comprise a flexible membrane material that inflates and stretches over at least a portion of the cartridge to conformally contact its first/top surface.

The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.

An aseptic sampling apparatus includes an isolator, a liquid delivery port that is disposed in the isolator, a sampling section that is disposed inside the isolator, a first flow path that communicates with a discharge flow path of the sampling section, and that connects an inside and outside of the isolator to each other through the liquid delivery port, a fluid supplying unit that supplies a fluid to the sampling section, a gas supplying unit that communicates with the fluid supplying unit, and a seal member that prevents the fluid supplied from fluid supplying unit to the discharge flow path from leaking.

A skewer-type gripper for one-sidedly receiving a test sample positioned in a defined manner and still compressed by plungers in a punching device and consisting of viscoelastic materials with an upper side and an edge area. The gripper has a base and skewer-type means arranged in a plane therein, which can pierce into the edge area of the still compressed test sample parallel to the upper side. The skewer-type means are configured in such a way that the test sample can be received and held in a torque-proof manner by the skewer-type means. The gripper is configured and set up for horizontally receiving the test sample from a punching device, and the gripper or skewer-type means can be exposed to a feed force for this purpose.

The present disclosure discloses an electronic cooling anti-condensation system, and an anti-condensation method for the same. The system comprises a testing chamber, electronic cooling plates, temperature sensors, a temperature and humidity sensor, a cooling plate control unit, and a main controller. The main controller is electrically connected to the temperature sensors, the temperature and humidity sensor, and the cooling plate control unit. The main controller is capable of calculating a dew point value of the air in the testing chamber according to a temperature value and a humidity value of the interior the testing chamber acquired by the temperature and humidity sensor, and if the dew point value of the air is greater than a pre-determined threshold, the main controller controls the cooling plate control unit to reduce the number of operating electronic cooling plates or output powers of the electronic cooling plates, wherein the pre-determined threshold is a temperature T1° C. of the electronic cooing plate or a temperature T1+n° C. of the electronic cooling plate acquired by the temperature sensor, and n≤is less than or equal to 10. The present disclosure achieves real-time control of operation states of the electronic cooling plates, thereby realizing redundant control of the cooling plates, and preventing the cooling plates from causing condensation in the chamber body, so as to achieve continuous operation when a failure occurs.

An environment forming device includes: a device body having a space for generating a predetermined environment; a door; and a slide mechanism that makes the door slidable with respect to the device body so as to open and close the space. The slide mechanism includes an extension member having an elongated shape fixed to the door, and a holding portion that is arranged on the device body and slidably holds the extension member. A reception portion for a sample is arranged on the door such that the sample is arranged in the space in a state where the door closes the space. The extension member is positioned below the reception portion.

A droplet dispensing apparatus includes a crystal sensor, a resonance frequency measuring unit, and a controller. The controller is configured to obtain the resonance frequency of the crystal sensor before droplets are discharged from a liquid dropping device, control the liquid dropping device to discharge droplets on to the crystal sensor, and obtain the resonance frequency of the crystal sensor after droplets are discharged from the liquid dropping device. The controller estimates a volatilization amount for the droplets on the crystal sensor based on a temporal change trend in the resonance frequency of the crystal sensor and calculates the total weight of the droplets discharged from the liquid dropping device based on the difference in resonance frequency of the crystal sensor before and after the droplets are discharged and the estimated volatilization amount.

Devices, systems, and associated methods are provided for manipulating and/or determining one or more characteristics of cells contained within a biological sample. In particular a device and methods of use thereof are provided, the device comprising a sorting component configured to separate cell-containing microdroplets from empty ones into a population of cell-containing first microdroplets; a microdroplet manipulation component configured to manipulate the first microdroplets using real or virtual electrowetting electrodes, and an optical detection system configured to detect an optical signal from the microdroplets via the one or more detection windows.

The present disclosure provides microfluidic test platforms, systems, and methods for manufacturing the disclosed test platforms. The present disclosure further provides uses of the disclosed microfluidic test platforms in personalized medicine. Specifically, in providing prognostic and therapeutic methods for determining drug sensitivity and optimizing treatment regimen for subjects suffering from a pathologic disorder, specifically, cancer.