Disclosed herein are devices, apparatuses, and methods for grinding of samples. A method includes securing a sample vial in a holder attached to a connecting linkage, the sample vial having a grinding media in the sample vial. The method includes rotating a crank that is operatively coupled to a proximal end of the connecting linkage at a proximal pivot point so that the proximal pivot point undergoes rotational motion. The method includes restricting a distal pivot point of the connecting linkage to a linear path, the distal pivot point near a distal end of the connecting linkage. A result being that the sample vial undergoes a combination of rotational and linear motion.

Disclosed herein are devices, apparatuses, and methods for grinding of samples. A method includes securing a sample vial in a holder attached to a connecting linkage, the sample vial having a grinding media in the sample vial. The method includes rotating a crank that is operatively coupled to a proximal end of the connecting linkage at a proximal pivot point so that the proximal pivot point undergoes rotational motion. The method includes restricting a distal pivot point of the connecting linkage to a linear path, the distal pivot point near a distal end of the connecting linkage. A result being that the sample vial undergoes a combination of rotational and linear motion.

A unit for grinding biological samples, comprising a grinding device including at least two tubes having different volumes, suitable for being mounted on a support of the grinding device, each tube comprising an inner space having a height (h) along the axis of the corresponding tube, and being intended to contain samples to be ground, means for driving the support in a precession movement, the support having an axis the position of which varies by describing a cone, each tube being subjected to a movement (d) defined by the projection, onto the axis of said cone, of the distance between the extreme positions of a same point of the tube during the precession movement.

A unit for grinding biological samples, comprising a grinding device including at least two tubes having different volumes, suitable for being mounted on a support of the grinding device, each tube comprising an inner space having a height (h) along the axis of the corresponding tube, and being intended to contain samples to be ground, means for driving the support in a precession movement, the support having an axis the position of which varies by describing a cone, each tube being subjected to a movement (d) defined by the projection, onto the axis of said cone, of the distance between the extreme positions of a same point of the tube during the precession movement.

A bead beater homogenizer includes a shaft having a main body extending along a main axis and a distal connection body extending along a connection axis that is acutely angled with respect to the main axis, a motor configured to rotate the shaft about the main axis, a head rotatably connected to the distal connection body of the shaft, and a clamp secured to the head and configured to secure a sample vial holder configured to hold one or more sample vials therein, wherein rotational motion of the shaft about the main axis is translated into motion of the head in directions normal to the main axis. A sample vial holder having an internal network of channels defined within the housing through which a coolant can be passed to control a temperature of a vial disposed therein is also provided.

A system includes a platform having an upper surface and defining a recess having a floor, the recess configured to seat a dish, and a movable securing frame that is movably connected with the platform, the frame including a lift support having an upper surface that is movable along a path from a first location that is beneath the floor of the recess, through the recess, to a second location that is coplanar with the upper surface of the platform. A motor configured to cause oscillation of the platform and the movable securing frame can be used. A method of using the system can include placing a dish above a recess defined by an upper surface of a platform, and lowering the frame with respect to the platform, thereby seating the dish within the recess.

A system includes a platform having an upper surface and defining a recess having a floor, the recess configured to seat a dish, and a movable securing frame that is movably connected with the platform, the frame including a lift support having an upper surface that is movable along a path from a first location that is beneath the floor of the recess, through the recess, to a second location that is coplanar with the upper surface of the platform. A motor configured to cause oscillation of the platform and the movable securing frame can be used. A method of using the system can include placing a dish above a recess defined by an upper surface of a platform, and lowering the frame with respect to the platform, thereby seating the dish within the recess.

A grinding machine includes a slight gyration module for driving a homogeneous container to undergo an X-axial motion and a Y-axial motion within 1-3 mm distance, a homogeneous-stick rotation module for rotating a homogeneous stick in the homogeneous container so as to generate an eccentric motion between the homogeneous stick and the homogeneous container, and a homogeneous-stick vertical movement module for vertically moving the homogeneous stick with respect to the homogeneous container. When the homogeneous stick is lowered into the homogeneous container by the homogeneous-stick vertical movement module, an eccentric motion with a 1-3 mm radius of gyration can be activated between the homogeneous container and the homogeneous stick so as to carry out the grinding in a tiny slim space between the homogeneous container and the homogeneous stick; such that the grinding efficiency of the grinding machine can be substantially enhanced.

A grinding machine includes a slight gyration module for driving a homogeneous container to undergo an X-axial motion and a Y-axial motion within 1-3 mm distance, a homogeneous-stick rotation module for rotating a homogeneous stick in the homogeneous container so as to generate an eccentric motion between the homogeneous stick and the homogeneous container, and a homogeneous-stick vertical movement module for vertically moving the homogeneous stick with respect to the homogeneous container. When the homogeneous stick is lowered into the homogeneous container by the homogeneous-stick vertical movement module, an eccentric motion with a 1-3 mm radius of gyration can be activated between the homogeneous container and the homogeneous stick so as to carry out the grinding in a tiny slim space between the homogeneous container and the homogeneous stick; such that the grinding efficiency of the grinding machine can be substantially enhanced.

Disclosed herein are devices, apparatuses, and methods for grinding of samples. A method includes securing a sample vial in a holder attached to a connecting linkage, the sample vial having a grinding media in the sample vial. The method includes rotating a crank that is operatively coupled to a proximal end of the connecting linkage at a proximal pivot point so that the proximal pivot point undergoes rotational motion. The method includes restricting a distal pivot point of the connecting linkage to a linear path, the distal pivot point near a distal end of the connecting linkage. A result being that the sample vial undergoes a combination of rotational and linear motion.