An apparatus and method for separating a target material. The apparatus for separating a target matter includes a mixture including a target matter, a density gradient material layer disposed under the mixture and having a greater density than a density of the mixture, magnetic beads including a magnetic material and binding to the target matter to form a complex, and a magnetic field generating device applying a magnetic field to the complex to precipitate the complex at the bottom of the density gradient material layer.

A dirt separator including a vessel having a separation container having a lateral container wall, a container bottom, and a container axis, which container has an inlet and an outlet as well as an interior, and having a particle separation chamber, which is disposed at the outlet of the separation container and stands in a fluid connection with the separation container, an inlet for supply of liquid into the vessel, and an outlet for discharge of the liquid out of the vessel. The dirt separator is configured in such a manner that liquid introduced into the separation container flows downward along the container wall in a cyclone-like movement, and then flows upward to the particle separation chamber within the liquid that flows downward in cyclone-like manner, and the dirt separator includes at least one particle separator, which is disposed in the particle separation chamber.

A device comprises a contact reaction chamber, a circulating water inlet, a clear water basin, a circulating pump, a circulating water outlet, a solid phase extractant collecting tank, a magnetic holder, an electromagnet, a solid-liquid separation area, a drain valve, a wall sprinkling water inlet, and a wall sprinkling pipe, wherein, the contact reaction chamber is in a conical shape, and utilizes hydraulic power to perform stir to ensure no dead corner exists during contact stir; the obconical solid-liquid separation area increases the action area between a magnetic solid phase extractant and the electromagnet; the solid phase extractant collecting tank is in a downwards protruding dish shape to prevent the solid phase extractant from losing.

Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining T cell reactivity with a library of candidate peptide antigens.

A discontinuous wall magnet having an opening or channel is provided. A bead separation magnet having a discontinuous or segmented wall is also provided. The segmented wall causes bead formation to form in a segmented or gapped ring to allow for easier manual pipetting. Also provided are systems and kits having the inventive magnets. Methods of purifying a macromolecule using the inventive magnets are also provided.

The present disclosure relates to a filter, which comprises a housing, a protective bushing, a magnetic bar and a filter screen. The protective bushing, the magnetic bar and the filter screen are disposed in the housing. The protective bushing comprises a cavity and a channel. The channel is disposed along the axial direction of the cavity. The advantageous effects of the filter according to the present disclosure lies in that: the magnetic bar inside the filter can adsorb metal impurities in the water in the channel; and the channel is in S shape which can increase the length of the flow path of the water so that the metal impurities in the water can be guaranteed to be sufficiently adsorbed by the magnetic bar; and the filter screen can filter out non-metal impurities in the water. An exhaust valve provided at the top of the protective bushing can keep the balance between the air pressure inside the filter and the air pressure outside the filter, which can ensure that the water can flow out and in smoothly. The filter is attached with an operating handle. If the user wants to disassemble the filter to clear up the metal impurities and non-metal impurities in the filter, he can disassemble the filter by means of the operating handle without the need of professional operator, which is convenient and simple.

The invention, provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

Some described examples relate to an apparatus for removing magnetically active particles from a fluid. The apparatus comprises at least one vessel for receiving a fluid comprising magnetically active or ferrous particles, and at least one electromagnet operable to produce a magnetic field within the vessel to act on the magnetically active or ferrous particles in use.

A strainer (101) for use in fluid piping. The strainer (101) comprises a body (102) for connection to a fluid piping inflow conduit (201) and to a fluid piping outflow conduit (202). The body (102) defines an interior chamber (103), a fluid inlet port (104) and a fluid outlet port (105). The body (102) defines a fluid flow path (106) between the fluid inlet port (104) and the fluid outlet port (105) that extends through the interior chamber (103). The strainer (101) comprises a screen collector (107) that is removably locatable in the body (102), within the fluid flow path (106). The strainer (101) further comprises a permanent magnet collector (102) that is removably locatable in the body (102). The strainer (101) may be used in fluid circuit piping of a heating or a cooling system.

Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a portion of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.