A customized tracheocutaneous fistula and tracheostomy plug having a face plate and a body customized to the anatomy of a patient is disclosed. The face plate has a face plate diameter, and the body has a first end connected to the face plate and a second end, a shoulder connected at the second end, and a tapered tip extending from the shoulder. The body has a body length extending from the first end to the second end and a shoulder diameter. The face plate diameter and the shoulder diameter are each greater than a measured minimum stoma diameter, and the body length is equal or substantially equal to a measured stoma length. Also, a mold-based method and a direct method of manufacturing the plug.

Tissue processing techniques are described involving association of tissue with a form under pressure to more precisely adapt the crosslinked tissue to the form. Pressure can be applied through holding of the issue on a porous form with suction on the form maintain tight adherence of the tissue on the form. In some embodiments, the tissue on the form is placed with the crosslinking solution in a bag that is then vacuum sealed to have the evacuated bag hold the tissue on the form. Whether or not the tissue is crosslinked on a form, glutaraldehyde can be used for crosslinking in a substantially unpolymerized state to achieve distinct crosslinked tissue properties.

The present disclosure provides a dental orthodontic appliance and a design method and a manufacturing method thereof. The dental orthodontic appliance includes a shell-like body, and the shell-like body is provided with a plurality of cavities for accommodating maxillary teeth, and the shell-like body is further provided with an upper palatal arch that reshapes a form of a dental arch. Two ends of the upper palatal arch are respectively and partially connected to positions of gingival margins or positions adjacent to the gingival margins on ligual sides in posterior regions of left and right sides of the shell-like body. When the shell-like body interacts with teeth, the upper palatal arch can induce buccolingual lateral amplification of maxillary palatal suture bone deposition by means of deformation, and teeth in the posterior regions move laterally buccolingually under an action of the shell-like body.

A periodontal tissue regeneration inducer and an apparatus and a method for manufacturing the same are provided. The periodontal tissue regeneration inducer includes a sheet body formed of a flexible material, and a pattern layer having a pattern formed therein to facilitate bone formation or regeneration on a surface of the sheet body. Therefore, the periodontal tissue regeneration inducer and the apparatus and method for manufacturing the same have an advantage in that the bone formation or regeneration may be facilitated during implant surgery because the membrane sheet is composed of a polycaprolactone (PCL) material and a nanopattern is formed on a surface of the pattern layer.

A flexible sheet for neurostimulation is described having a flexible non-conductive substrate matrix in which electrodes are embedded along a lower surface. Electrically conductive wires extend from the electrodes through the flexible substrate to another exterior surface of the substrate. Methods of making the flexible sheet and making a device using the flexible sheet are also disclosed.

A device for separating a deep-drawn jaw-spanning dental apparatus such as an aligner or a bite splint of thermoform film that includes: a separating element for thermally separating the deep-drawn thermoform film and simultaneously refining, the separated deep-drawn thermoform film; a heating means for regulating the heating of the separating element so as to increase the temperature of the thermoform film substantially to at least its glass temperature; a support for supporting the deep-drawn thermoform film relatively movable with respect to the separating element; a moving mechanism for moving the separating element along a separation contour of the deep-drawn jaw-spanning dental apparatus relative to the support; and a control unit adapted to control the heating means and the moving mechanism based on the separation contour.

Disclosed is a method for producing at least one molded, filled and sealed container product (10) comprising at least the method steps listed below: extruding a hose (32) by means of an extrusion device (12) using supporting gas in vertical extrusion direction in a preforming position; sealing the hose (32) at its lower end and cutting it at its upper open end; transporting of the parison (22) thus cut to length by means of a gripper device (20) in linear transport direction transverse to the extrusion direction from the preforming position into an opened molding tool (18); transferring the parison (22) into the opened molding tool (18) by means of the gripper device (20) in a main forming position; sealing the molding tool (18) for further forming of the parison (22) by a pressure gradient; filling and sealing the parison (22); and returning the gripper device (20) to the preforming position for a repeated sequence of the above method steps

An orthodontic appliance may include an outer shell having a plurality of cavities shaped to receive the patient's teeth and generate one or more of a force or a torque in response to the appliance being worn on the patient's teeth. The orthodontic appliance may also include an inner structure having a stiffness different than a stiffness of the outer shell. The inner structure can be positioned on an inner surface of the outer shell in order to distribute the one or more of a force or a torque to at least one tooth received within the plurality of cavities.

The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.

A method of constructing an inflatable fluidic actuator that includes generating a tube configuration with one or more shapes of fluid-impermeable membrane material, the tube configuration having a first tube end and a second tube end and an internal tube face and an external tube face. The method also includes coupling a first and second interface to the tube configuration at the first and second tube ends by respectively coupling each interface to the tube configuration at a respective tube end by generating at least one of: a first circumferential bond between the fluid-impermeable membrane material and one or more sidewalls of the interface; and an external face bond between fluid-impermeable membrane material at the tube end onto an external face of the interface.