Multilayer polymer sheets are provided, as well as related methods, systems, and appliances.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

Dental retainer devices are provided. The dental retainer devices can be customized based on patient specific dental anatomy and dental treatment plans. Methods of making the dental retainer devices are also provided. The methods can included additive manufacturing. Methods are also provided for customization of a dental retainer device based on the patient specific anatomy. The methods for customization can include providing a dentist with different options for anterior teeth coverage, posterior teeth coverage, and palatal configurations for the dental retainer devices.

Systems and methods for controlling a pump system for use in negative pressure wound therapy are described herein. In some embodiments, a method for controlling a pump system includes applying a drive signal to a pump assembly of the pump system, the drive signal alternating between a positive amplitude and a negative amplitude and the drive signal having an offset, and sampling a pressure within a fluid flow path configured to connect the pump system to a wound dressing configured to be placed over a wound during one or more time intervals. Each of the one or more time intervals can occur when the drive signal is approximately at an amplitude equal to one or more sampling amplitudes.

Disclosed is a device for manufacturing a skin-simulating phantom, which has properties that are similar to those of real skin, using a 3D printer so that layers are stacked to form a multi-layered structure and a nozzle tip connected to the 3D printer is used to provide roughness, and a method of manufacturing a skin-simulating phantom using the same. According to this present invention, solutions can be mixed, depending on the component constitution reflecting the optical properties of the skin, using a program that is set depending on the type of skin. The output condition of the 3D printer can be controlled using a program that is set so as to conduct a step of comparing measured thickness and roughness values to those of the real skin and performing feedback. The nozzle tip connected to the 3D printer can move up and down to provide roughness. Further, the multi-layered structure can be manufactured using the 3D printer, thereby outputting and embodying lesions.

The present disclosure provides tissue wrap devices with embedded three dimensional attachment features, methods of manufacturing three-dimensional attachment features for tissue wrap devices, and methods of using a nerve wrap device to protect a damaged nerve. Tissue wrap devices of the present disclosure may include a sheet of biocompatible material, the sheet having a first side, a second side, a middle portion, a first outer portion, and a second outer portion, the first side of the first outer portion being configured to overlap and interface with the second side of the second outer portion when the sheet is transitioned to a rolled configuration; wherein the first side of the first outer portion comprises a plurality of three dimensional attachment features; and wherein the plurality of three dimensional attachment features are configured to engage with the second side of the second outer portion to maintain the sheet in the rolled configuration.

A parison for being blow molded into a medical balloon for a catheter includes a first tubular layer having a functional modification and a second tubular layer adapted for bonding with the first tubular layer to form the blow molded balloon. Related methods are disclosed.

Methods for fabricating attachment placement appliances are provided. In some embodiments, a method includes directly fabricating an attachment placement appliance body including a support formed in a tooth-receiving cavity configured to receive a tooth. The method can include directly fabricating one or more coupling structures connected to the support, and directly fabricating an aligner attachment connected to the one or more coupling structures. The attachment placement appliance body can be configured to align the aligner attachment to a predetermined location on the tooth. The aligner attachment can be shaped to engage with an attachment well of a shell aligner and exert one or more forces on the tooth when the aligner attachment is coupled to the attachment well. The one or more coupling structures can be configured to release the aligner attachment with removal of the attachment placement appliance body from the tooth.

The present invention relates to a method for three dimensional printing of a porous object enabling the capillary transport of hydrophilic fluids, for use as liquid handling device, for example as a point of care diagnostic device. The invention also provides the porous object obtainable or obtained by such methods, and its use in liquid handling or as a point of care diagnostic device.

Provided is a transdermal absorption sheet capable of improving strength against impact at the time of puncture. A transdermal absorption sheet includes a sheet portion and a plurality of needle-like protruding portions arranged on a first principal surface of the sheet portion, in which the sheet portion has a center portion which is a region in which the plurality of needle-like protruding portions are formed, and an outer edge portion which is a region from the center portion to an end portion, and a maximum thickness of a thickness portion of the outer edge portion is larger than an average thickness of the center portion.