The invention provides a solid-dosage-form printing apparatus comprising: i) a 3D printer suitable for printing solid-dosage-forms, said 3D printer comprising an interchangeable print head selected from the group consisting of: a fused deposition modelling print head, a semi-solid extrusion print head and a direct powder extrusion print head; ii) a build platform; iii) a balance for measuring the mass of the printed solid-dosage-forms, said balance being integrated into said build platform; and optionally iv) means for performing in-line near-infra-red and/or raman spectroscopy on the solid-dosage-form product; wherein said solid-dosage-form comprises at least one active-ingredient and at least one excipient. Further provided are methods of producing solid-dosage-forms using the apparatus, including computer-implemented methods.

The present invention relates to a porous scaffold having excellent tissue engineering properties, and a method for manufacturing same. The scaffold of the present invention can be manufactured by a simple process, and exhibits high tensile strength and biocompatibility, as well as an excellent cell engraftment rate, and thus can be useful as a support composition for various of human transplantation, for example, as a support for artificial ligaments or abdominal wall reinforcement.

Transdermal medicaments containing cannabidiol (CBD) for use in the amelioration of conditions, including anxiety, depression, pain, inflammation, epilepsy, parkinson's disease, oxidative injury and nausea; and a method for preparing same.

A high-strength absorbable internal fixation bone screw for a fracture. The bone screw is made of a degradable oriented polylactic acid section. A raw material for the oriented polylactic acid section is a poly(L-lactic acid). The specific optical rotation of the poly(L-lactic acid) is −155° to −160°. The section is made of the poly(L-lactic acid) through the processes of making a billet, orientation strengthening and quenching in order. The method for making the billet is plastic injection molding. The method for orientation strengthening is forging and pressing or extrusion. The section is turned, finely milled, or directly molded into the bone screw. The bone screw has high strength and a low rate of mechanical strength loss, ensures mechanical support during bone healing and sufficient healing time for an injured bone, has good biocompatibility, and can be degraded and absorbed.

A dressing for treating a tissue site with negative pressure may comprise a cover having an adhesive, a manifold, a perforated polymer film, and a perforated silicone gel having a treatment aperture. The cover, the manifold, the perforated polymer film, and the perforated silicone gel may be assembled in a stacked relationship with the cover and the perforated silicone gel enclosing the manifold. The perforated polymer film may be at least partially exposed through the treatment aperture, and at least some of the adhesive may be exposed through the perforated silicone around the treatment aperture.

A process for producing an electrical conductor structure that involves embedding at least one metallic conductor track and at least one heating conductor in an electrically insulating substrate, and producing an electric current in the heating conductor so that a first layer of the substrate and a second layer of the substrate fuse in an area surrounding the heating conductor, to seal an interface between the two layers. A conductor structure is also disclosed, in particular in the form of an implantable electrode lead.

Method for determining a manufacturing parameter for making an aligner with a desired aligner thickness using a thermoforming device operable for making the aligner by shaping a precursor aligner into the aligner using a mold representative of a dental archform, the method comprising: obtaining a 3D map associated with the dental archform; parsing the 3D map to determine a first property value and a second property value, the first property value being based on the 3D map and the second property value being derived from a 2D projection of the 3D map, and determining a thickness of the precursor aligner for obtaining the desired aligner thickness based on a ratio of the first property value and the second property value and a given value of an operating parameter of the thermoforming device; and sending instructions to the thermoforming device to make the desired aligner based on the determined operating parameter.

An implantable medical device is disclosed comprising a thermoplastic composite body having anterior, first lateral, second lateral, posterior, superior, and inferior surfaces, and at least one dense portion and at least one porous portion which are integrally formed. The at least one dense portion is formed of a first thermoplastic polymer matrix that is essentially non-porous, and which is continuous through a thickness dimension from the superior surface to the inferior surface. The at least one porous portion is formed of a porous thermoplastic polymer scaffold having a second thermoplastic polymer matrix which is continuous through the thickness dimension. A method for forming the thermoplastic composite body is disclosed comprising disposing a first powder mixture in a first portion of a mold, disposing a second powder mixture in a second portion of the mold, simultaneously molding the first powder mixture and the second powder mixture, and leaching porogen.

The present invention provides a thin and flexible device and method of use thereof for wound treatment and infection control. The integrated surface stimulation device may comprise wireless stimulation system in a disposable and/or reusable flexible device for widespread use in multiple therapeutic applications. The invention would be situated on the skin surface of a patient and would be activated so as to reduce the overall occurrence of infections and/or increase wound healing rates. As provided, the device will comprise an integrated power supply and pre-programmable stimulator/control system on a flexible polymeric substrate layer with areas of stimulating electrodes, applied using techniques such as those found in additive manufacturing processes. The device is especially valuable in treating biofilm-based infections.

Continuous adjustment appliances are provided that can store a large number of geometries that can be successively accessed throughout orthodontic treatment, with each geometry can correspond to an arrangement of the patient's teeth. An appliance according to the present disclosure can be stimulated to transition among the myriad geometries, which can include changes to the overall shape of the appliance as well as the position and geometry of the cavities corresponding to a patient's teeth. Methods of creating the continuous adjustment appliances and methods of treatment using the continuous adjustment appliances are also revealed.