The invention relates to a rotary press having height-staggered ram tips for carrying out at least two pressing operations, which preferably build on one another. Furthermore, the invention relates particularly to rotary presses and methods for producing multi-layer and coating-core tablets and for pressing tablets into cups during a rotation.

The invention relates to a rotary press having height-staggered ram tips for carrying out at least two pressing operations, which preferably build on one another. Furthermore, the invention relates particularly to rotary presses and methods for producing multi-layer and coating-core tablets and for pressing tablets into cups during a rotation.

A sample encapsulation system (10) includes a fixture, a base (12), a chamber (14) having an inlet and a chamber housing (16). The housing (16) has inner (36) and outer (38) housings. The chamber (14) is fixedly mounted in the inner housing (36). The base, chamber (14) and housing (16) are affixed relative to one another and movable relative to the fixture. The system includes a cap (78) and a first ram (80) operably mounted to the cap (78) for engaging the chamber inlet. A second ram (24) is positioned in the chamber (14) opposite the inlet and moves toward and away from the first ram (80). The second ram (24) is driven by a cylinder. A heating assembly is positioned in the inner housing (36) and a cooling assembly which includes a cooling jacket (50) defined in part by the inner housing (36) and the outer housing (38) includes a manifold (60). The chamber (14), chamber housing (16) and base (12) are movable toward the cap (78) for engaging the first ram (80) with the chamber inlet during an encapsulation cycle and away from the cap (78), disengaging the first ram (80) from the chamber inlet following an encapsulation cycle. The cooling system includes a vacuum breaker (62) to self-drain following cooling.

A sample encapsulation system (10) includes a fixture, a base (12), a chamber (14) having an inlet and a chamber housing (16). The housing (16) has inner (36) and outer (38) housings. The chamber (14) is fixedly mounted in the inner housing (36). The base, chamber (14) and housing (16) are affixed relative to one another and movable relative to the fixture. The system includes a cap (78) and a first ram (80) operably mounted to the cap (78) for engaging the chamber inlet. A second ram (24) is positioned in the chamber (14) opposite the inlet and moves toward and away from the first ram (80). The second ram (24) is driven by a cylinder. A heating assembly is positioned in the inner housing (36) and a cooling assembly which includes a cooling jacket (50) defined in part by the inner housing (36) and the outer housing (38) includes a manifold (60). The chamber (14), chamber housing (16) and base (12) are movable toward the cap (78) for engaging the first ram (80) with the chamber inlet during an encapsulation cycle and away from the cap (78), disengaging the first ram (80) from the chamber inlet following an encapsulation cycle. The cooling system includes a vacuum breaker (62) to self-drain following cooling.

A tablet sampler assembly is provided for a tablet coating machine which comprises a rotatable drum for containing a bed of tablets being coated. The tablet sampler assembly comprises a housing configured for attachment to said tablet coating machine, and a receptacle for receiving a sample of said tablets. At least a portion of the receptacle is movable between a collecting position in which the receptacle is configured to be in communication with the interior of the drum, thereby enabling collection of a sample by the receptacle from the drum, and a non-collecting position in which the receptacle is configured to be substantially out of communication with the interior of the drum.

The invention relates to a method for producing a molded piece (compression molding, molded body) using a compression molding device. The use of special construction features for the compression molding device, such as a spring-loaded punch, an intermediate punch and clamps, allows the advantageous production of molded pieces.

The invention relates to a method for producing a molded piece (compression molding, molded body) using a compression molding device. The use of special construction features for the compression molding device, such as a spring-loaded punch, an intermediate punch and clamps, allows the advantageous production of molded pieces.

The purpose of present invention to provide a method for the production of an easy-to-take solid preparation, which is mainly characterized in that a coating processing for the easy-to-take property is simply performed by using a gelling agent in a dry process, without going through a wet condition, the easy-to-take solid preparation and the like.

The present invention relates to a dry-process method for the production of an easy-to-take solid preparation wherein a compression-molded core is coated with a coating agent comprising a gelling agent that will show slipperiness when it is brought into contact with water, comprising directly applying only powder of the coating agent to a mortar inner surface, the bottom end surface of an upper-pestle, and the top end surface of a lower-pestle, and subsequently loading and integrally compression-molding a core-molding material; a powder composition for coating the solid preparation, which comprises a water-soluble polymer to be used in the aforementioned production method, and the like.

The purpose of present invention to provide a method for the production of an easy-to-take solid preparation, which is mainly characterized in that a coating processing for the easy-to-take property is simply performed by using a gelling agent in a dry process, without going through a wet condition, the easy-to-take solid preparation and the like.

The present invention relates to a dry-process method for the production of an easy-to-take solid preparation wherein a compression-molded core is coated with a coating agent comprising a gelling agent that will show slipperiness when it is brought into contact with water, comprising directly applying only powder of the coating agent to a mortar inner surface, the bottom end surface of an upper-pestle, and the top end surface of a lower-pestle, and subsequently loading and integrally compression-molding a core-molding material; a powder composition for coating the solid preparation, which comprises a water-soluble polymer to be used in the aforementioned production method, and the like.

The purpose of present invention to provide a method for the production of an easy-to-take solid preparation, which is mainly characterized in that an outer layer-forming processing to provide an easy-to-take property is simply performed in a dry process without going through a wet condition so as to make the formed outer layer thicker; the easy-to-take solid preparation and the like.

The present invention relates to a dry-process method for the production of an easy-to-take solid preparation wherein an inner core tablet is coated with a compression-molded outer layer-forming agent comprising a gelling agent that will show slipperiness when it is brought into contact with water, comprising loading separately or simultaneously the inner core tablet and powder of the outer layer-forming agent to a mortar inner surface, the bottom end surface of an upper-pestle, and the top end surface of a lower-pestle, and subsequently compression-molding them; a powder composition for coating a solid preparation for use in the above method, which comprises the water-soluble polymer and water-soluble sugar or sugar alcohol