The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Disclosed is a peroral endoscopic apparatus of a swallowable type, the peroral endoscopic apparatus including: at least one imaging unit configured to perform imaging of a human body digestive system and output image data; at least one ultrasonic unit configured to output ultrasonic data on a submucosal region of the digestive system and a peripheral organ located therearound; a magnetic unit configured to adjust a position, a posture, and a proceeding direction of the peroral endoscopic apparatus in response to an external magnetic force; a transceiving unit configured to transmit the image data and the ultrasonic data to an external device or receive an external control signal; a control unit configured to control the imaging unit and the ultrasonic unit to perform imaging of the digestive system and the submucosal region simultaneously or individually; and a power supply unit configured to supply power.

Fluorescence imaging with reduced fixed pattern noise is disclosed. A method includes actuating an emitter to emit a plurality of pulses of electromagnetic radiation and sensing reflected electromagnetic radiation resulting from the plurality of pulses of electromagnetic radiation with a pixel array of an image sensor to generate a plurality of exposure frames. The method includes applying edge enhancement to edges within an exposure frame of the plurality of exposure frames. The method is such that at least a portion of the plurality of pulses of electromagnetic radiation emitted by the emitter comprises one or more of electromagnetic radiation having a wavelength from about 770 nm to about 790 nm.

A telesurgical mentoring platform with a wheeled base, a lower rack mounted on the base, an upper rack extending vertically from the lower rack, a compactly foldable articulated arm that is configured to extend horizontally outward away from the upper rack and configured to connect to a connector piece holding an end effectuator at its distal end, a tablet personal computer; the console configured to be readily mobilized on the floor of an existing operating room and is capable of providing a connectivity point for communication, audiovisual, and data transfer services in an operating room.

Provided are a capsule endoscope apparatus for supporting a lesion diagnosis and a lesion diagnosis supporting method using the same. The capsule endoscope apparatus for supporting lesion diagnosis includes an imaging unit configured to capture one or more images of an inside of a body, a control unit configured to detect a suspected lesion region in the images and perform a precision diagnosis procedure when a suspected lesion region corresponding to a value equal to or greater than a certain threshold is detected, an image processing unit configured to process the images in the precision diagnosis procedure, and a communication module configured to transmit and receive processed images to another capsule endoscope apparatus or a terminal by using a wireless communication method.

Endoscopes of this disclosure, such as colonoscopes, provide a broader field of view and allow extended access of surgical tools, and also enable efficient packing of all necessary elements in the tip section, while maintaining their functionality. Methods and systems of this disclosure include for capturing and displaying still and video images using an endoscope corresponding to a left-side looking viewing element, a front-looking viewing element, and a right-side looking viewing element of an endoscopic tip generated in a native aspect ratio.

Endoscopes of this disclosure, such as colonoscopes, provide a broader field of view and allow extended access of surgical tools, and also enable efficient packing of all necessary elements in the tip section, while maintaining their functionality. Methods and systems of this disclosure include for capturing and displaying still and video images using an endoscope corresponding to a left-side looking viewing element, a front-looking viewing element, and a right-side looking viewing element of an endoscopic tip generated in a native aspect ratio.

A visualization system including multiple light sources, an image sensor configured to detect imaging data from the multiple light sources, and a control circuit is disclosed. At least one of the light sources is configured to emit a pattern of structured light. The control circuit is configured to receive the imaging data from the image sensor, generate a three-dimensional digital representation of the anatomical structure from the pattern of structured light detected by the imaging data, obtain metadata from the imaging data, overlay the metadata on the three-dimensional digital representation, receive updated imaging data from the image sensor, and generate an updated three-dimensional digital representation of the anatomical structure based on the updated imaging data. The visualization system can be communicatively coupled to a situational awareness module configured to determine a surgical scenario based on input signals from multiple surgical devices.

An endoscope with an optical channel is held and positioned by a robotic surgical system. A capture unit captures (1) a visible first image at a first time and (2) a visible second image combined with a fluorescence image at a second time. An image processing system receives (1) the visible first image and (2) the visible second image combined with the fluorescence image and generates at least one fluorescence image. A display system outputs an output image including an artificial fluorescence image.

A manipulation assembly includes a delivery catheter having a lumen extending therethrough and a deployment catheter positioned within the delivery catheter. The deployment catheter is independently manipulatable with respect to the delivery catheter. The assembly further includes a visualization element extendable distally beyond the deployment catheter and an ablation probe comprising an energy transmitting surface positionable to ablate tissue adjacent to a distal end of the ablation probe. The ablation probe is extendable distally beyond the deployment catheter.