A multifunctional ophthalmic instrument and method for assessing ocular surface health is disclosed. The instrument includes an illumination projector, which contains broadband light sources, covering visible and near infrared spectra, a zoom lens system with continuously variable magnification, a detection system to record said images, and a computer to display and analyze said images. Preferably, an eye alignment system with a beamsplitter is used to provide a fixation target for the eye under assessment. An optional thermal camera, operating in the long wave infrared spectrum is aligned paraxially to the zoom lens system. Further, an optional separate video camera is used to monitor the blink rate. Corneal topography and tear break up time could be evaluated with a low magnification, and microscopic features, such as tear meniscus height, meibomian gland orifices, are imaged at a high magnification. Meibomian glands and lipid layer thickness are analyzed with visible and near infrared spectra.

In a general aspect, a structured optical beam with position-dependent polarizations is prepared for human observation. In some examples, an optics method includes processing an optical beam to produce a structured optical beam for human observation. Processing the optical beam includes receiving the optical beam from a laser source; attenuating the optical beam to an exposure irradiance level that is safe for direct viewing by a human eye; expanding the optical beam to a size configured for a field of view of the human eye; and preparing the optical beam with a position-dependent polarization profile. The structured optical beam, which has the position-dependent polarization profile, is directed towards an observation region for human observation.

Disclosed is an eye examination apparatus that can be used in professional settings. The eye examination apparatus has a body having a first eye opening and a second eye opening for a user to see into the eye examination apparatus using two eyes. The eye examination apparatus also has a first camera coupled to the body and positioned to acquire ophthalmic images through the first eye opening, and a second camera coupled to the body and positioned to acquire ophthalmic images through the second eye opening. The eye examination apparatus also has at least one display coupled to the body and positioned to be viewable through the first eye opening and the second eye opening.

In some embodiments, techniques for using machine learning to enable visible light pupilometry are provided. In some embodiments, a smartphone may be used to create a visible light video recording of a pupillary light reflex (PLR). A machine learning model may be used to detect a size of a pupil in the video recording over time, and the size over time may be presented to a clinician. In some embodiments, a system that includes a smartphone and a box that holds the smartphone in a predetermined relationship to a subject's face is provided. In some embodiments, a sequential convolutional neural network architecture is used. In some embodiments, a fully convolutional neural network architecture is used.

Accommodating ophthalmic devices including an ambient light sensor and an accommodation sensor and related methods of use are described. In an example, the accommodation sensor is configured to measure a biological accommodation signal of an eye on or in which the accommodating ophthalmic device is mounted. In an embodiment, the accommodating ophthalmic device is configured to measure the biological accommodation signals based on ambient light, such as based on an intensity or amount of ambient light, incident on the accommodating ophthalmic device. Such ambient light may be measured with the ambient light sensor.

A retinal imaging system is provided. The system comprises: a fundus camera having a focusing mechanism; an imaging module configured for imaging user's face and eyes and providing image date indicative of a relative orientation between an optical axis of the fundus camera and a line of sight of user's eye at user's eye target position; a position and alignment system configured and operable to utilize the image data indicative of said relative orientation for positioning the fundus camera at an operative position such that the optical axis substantially coincides with the line of sight of user's eye, to enable focusing the fundus camera on the retina; a sensing system comprising one or more sensors, configured and operable for monitoring a user's face position with respect to a predetermined registration position and generating corresponding sensing data; and a safety controller configured and operable to be responsive to the sensing data, and upon identifying that the user's face position with respect to the predetermined registration position

The present disclosure provides systems and methods for diagnosing disease. In some aspects, an imaging system is provided that includes a light source configured to illuminate a retina of the eye with light, one or more imaging devices configured to receive light returned from the retina to generate one or more spatial-spectral images of the retina, and a computing device configured to receive the one or more spatial-spectral images of the retina, evaluate the one or more spatial-spectral images, and identify one or more biomarkers indicative of a neurogenerative pathology.

An ophthalmic apparatus includes an illumination optical system that generates slit-shaped illumination light using a first light source; an optical scanner that deflects the illumination light to a fundus of a subject's eye; an imaging optical system that captures light from the fundus using a rolling shutter method; an acquisition unit that acquires a fundus image of the subject's eye using light from a second light source; a flare determination unit that determines whether or not flare occurs by analyzing the fundus image; a controller that performs flare optimization control by controlling at least one of the first light source, the illumination optical system, the optical scanner, the imaging optical system, and the image sensor based on a first determination result obtained by the flare determination unit; and an image forming unit that forms an image of the fundus when the flare does not occur.

A light shielding system configured to shield at least one eye of a patient from incident light for an electroretinogram includes a substantially lighttight shielding box enclosing an inner space arranged to receive a handheld Ganzfeld stimulator, which box is mountable over the at least one eye of the patient; the box including at least one sleeve extending into the box to allow manipulation of the Ganzfeld stimulator.

An ophthalmic portable laser slit lamp for ophthalmic examination and a method of eye inspection. The device comprises a portable housing containing an electronic timer circuit, a rechargeable battery, a laser module containing a laser emitting diode, a fixed focusing lens that sets the appropriate focal distance for the examination method and a line generator lens acting as a slit aperture. The laser beam aimed to the eye of the patient illuminates the eye with a very thin straight laser line at a fixed focal distance. The device also comprises a safety timer circuit that protects the patients eye against irradiation overload. The method of the invention allows the surgeon to detect surgical eye disorders at the operating room and helps to carry out a correct diagnosis in a much more precise and effective way than any light or laser spot device.