A biological information measuring apparatus includes a cover member and a hardware processor. The cover member is provided with sensors for detecting biological signals to cover a position of a biological part of a subject. The hardware processor is configured to estimate a positional relation of the position of the biological part of the subject with respect to the cover member at a first time point. The hardware processor superimposes first point cloud and second point cloud. The first point cloud is acquired by a non-contact mechanism front the subject at the first time point and represents a surface of the biological part of the subject in a coordinate system of the sensors. The second point cloud is created based on a morphological image of the subject captured by a biological structure acquiring apparatus and represents the surface of the biological part of the subject.

Provided herein are compounds useful for imaging granzyme B. An exemplary compound provided herein is useful as a radiotracer for position emission tomography (PET) and/or single photon emission tomography (SPECT) imaging. Methods of imaging granzyme B, combination therapies, and kits comprising the granzyme B imaging agents are also provided.

Fluorescence videostroboscopy imaging is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a controller configured to cause the emitter to emit the pulses of electromagnetic radiation at a strobing frequency determined based on a vibration frequency of vocal cords of a user. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 795 nm to about 815 nm.

A locator assembly (100) for determining a location of an arrhythmogenic foci (632) in or near a heart (101). The locator assembly (100) includes a device body (112) and a plurality of electrodes (102). The plurality of electrodes (102) receive electrical signals from the heart (101) to determine the location of the arrhythmogenic foci (632). The plurality of electrodes (102) can be coupled to the device body (112). At least two of the plurality of electrodes (102) can positioned circumferentially about the device body (112). The plurality of electrodes (102) can be positionable so that the plurality of electrodes (102) are in electrical communication with the heart (101).

A method for determining a location of an arrhythmogenic foci (632) in or near a heart (101) includes the steps of positioning a locator assembly (100) within the heart (101), the locator assembly (100) including a plurality of electrodes (102) that receive electrical signals from the heart (101), generating a first signal array (733) from the electrical signals received by the plurality of electrodes (102) to determine an actual location of the arrhythmogenic foci (632), artificially stimulating the heart (101) based on the actual location determined by the first signal array (733) to generate a second signal array (733), and confirming the actual location of the arrhythmogenic foci (632) by comparing the first signal array (733) with the second signal array (735). In some embodiments, the locator assembly (100) includes a plurality of bipolar electrodes (102).

There is provided herein a system and a method for an insertion device positioning guidance system comprising: an electromagnetic field generator configured to generate an electromagnetic field covering a treatment area; a reference sensor configured to be positioned, within the treatment area, on the subject's torso, the reference sensor is configured to define a reference coordinate system representing the position and orientation of the subject's torso relative to the field generator; a registration sensor configured to mark at least a first and a second anatomic locations relative to the reference coordinate system; and a processor configured to operate the field generator, read signals obtained from the reference sensor and the registration sensor, calculate a position and orientation thereof relative to the field generator, generate a 3D anatomic map representing the torso of the subject and the first and second anatomic locations, the processor is further configured to facilitate visualization on the 3D anatomic map of a position, orientation and/or path of a tip sensor, located in a distal tip section of the insertion device, with respect to the first and second anatomic locations, independent of the subject's movement and independent of deviations in the position and/or orientation of the field generator, thus determination of a successful medical procedure is facilitated.

Presented are systems and methods for the accurate acquisition of medical measurement data of a body part of patient. To assist in acquiring accurate medical measurement data, an automated diagnostic and treatment system provides instructions to the patient to allow the patient to precisely position a medical instrument in proximity to a target spot of a body part of patient. For a stethoscope examination, the steps may include utilizing object tracking to determine if the patient has moved the stethoscope to a recording site; utilizing DSP processing to confirm that the stethoscope is in operation, utilizing DSP processing to generate a pre-processed audio sample from a recorded audio signal; using machine learning (ML) to determine if a signal of interest (SOI) is present in the pre-processed sample. If SoI is present, using ML to evaluate characteristics in the signal which indicate the presence of abnormalities in the organ being measured.

The present invention relates to a portable probe for photoacoustic tomography, capable of performing line-by-line scanning or area-by-area scanning by using a small number of light inputs; and a real-time photoacoustic tomography device. The probe for photoacoustic tomography includes: a lens receiving light inputs from an optical fiber so as to make the same proceed as small diameter parallel light; a Powell lens receiving the small diameter parallel light and generating a line beam of a predetermined thickness, and allowing energy dispersed on a line to be uniform on the entire line; a lens making the line beam pass therethrough such that the line beam has a predetermined width and a reduced thickness so as to be line-focused at a target area; an acoustic reflection glass for separating, from a light path, an acoustic wave outputted from the target area; and an acoustic measurement unit for measuring acoustic strength.

A method for analyzing the biomechanical activity of a human subject and the exposure to a biomechanical risk factor in a context of physical activity, which comprises collecting signals from sensors of one or more muscles of the subject, collecting signals representing the movement of the subject, and processing these signals to extract signals representative of the vibratory behavior of the muscle or muscles of the subject. This method also comprises detecting a drift of the vibratory signals in relation to a frame of reference of the vibratory behavior of the muscle or muscles in the context of physical activity, and predicting a physiological break time necessary for the subject's muscles to recover their reference vibratory behavior.

This analytical data analysis method uses machine learning of analysis result data (31) measured by an analyzer (1), and includes generating simulated data (32) in which a data variation has been added to the analysis result data (31) within a range that does not affect identification, performing the machine learning using the generated simulated data (32), and performing discrimination using a discrimination criterion (23b) obtained through the machine learning.