Systems for detecting, locating and mitigating impact forces directed towards a person's head are described herein. The systems include devices for wearing on a wearer's head. The devices include a base configured to conform to the wearer's head and retain a plurality of pouches on an outer surface of the base. The plurality of pouches are configured to absorb at least a portion of the impact force directed towards the outer surface of the base, provide an indication when the impact force directed towards the outer surface of the base has a magnitude exceeding a concussion-indicating level of force, and provide a location of impact when the impact force directed towards the outer surface of the base has a magnitude exceeding the concussion-indicating level of force.

The present disclosure provides systems and methods for predicting a disease state of a subject using ultrasound imaging and ancillary information to the ultrasound imaging. At least two quantitative measurements of a subject, including at least one measurement taken using ultrasound imaging, as part of quantified information can be identified. One of the quantitative measurements can be compared to a first predetermined standard, included as part of ancillary information to the quantified information, in order to identify a first initial value. Further, another of the quantitative measurements can be compared to a second predetermined standard, included as part of the ancillary information, in order to identify a second initial value. Subsequently, the quantitative information can be correlated with the ancillary information using the first initial value and the second initial value to determine a final value that is predictive of a disease state of the subject.

The present invention relates to assessing a psychophysiological responsiveness or non-responsiveness of a subject. A device (10) for assessing a psychophysiological responsiveness of a subject is presented, the device comprising a stimulus unit (11) for providing an electrical stimulus via a first and a second electrode (21, 22) to a skin (100) of the subject; a sensing unit (12) for acquiring an impedance signal (15) indicative of an impedance between the first and the second electrode in response to said electrical stimulus; and an analysis unit (13) adapted to identify an electrical double-layer based on the impedance signal acquired in response to the electrical stimulus and to determine a psychophysiological responsiveness of the subject based on the identified electrical double-layer. It has been found that identifying the presence or absence of an electrical double-layer based on the impedance signal acquired in response to the electrical stimulus can serve as a reliable indicator whether the subject is in a responsive or nonresponsive psychophysiological state. Further, a corresponding method, computer program and system (1) are presented.

The present invention provides method for the quantitative or qualitive evaluation and ement of the user's cognitive ability, screening and improving pathological neurological ions. This is achieved by integrating and adapting current-in-practice cognitive assessment niques to an augmented/mixed reality system, which presents signals and stimulations in various forms to the user meanwhile recording user's surroundings, performance, and responses. The stimulations enhance users' cognitive functions, and the acquired data are evaluated by statistic methods to generate an evaluation that is more standardized and reflective of user's actual condition than current methods.

It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyzes. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.

A method for fast high-resolution deep photoacoustic tomography of action potentials in brains is provided herein. The method may utilize a high-speed, high-spatial-resolution, deep-penetration photoacoustic computed tomography (PACT) system for real-time imaging of action potentials.

It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyzes. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.

A bipolar stimulation probe including a first electrode, a second electrode, a control module, and switches. The control module is configured to stimulate nerve tissue of a patient by generating (i) a first output signal indicative of a first pulse to be output from the first electrode, and (ii) a second output signal indicative of a second pulse to be output from the second electrode. The first pulse and the second pulse are monophasic. The switches are configured to output from the bipolar stimulation probe (i) the first pulse on the first electrode based on the first output signal, and (ii) the second pulse on the second electrode based on the second output signal.

A method for detecting an artificially induced neuromuscular response in a subject includes receiving a mechanomyography (MMG) output signal from a mechanical sensor in contact with a muscle of the subject; applying one or more conditioning filters to the MMG output signal to generate a conditioned signal and analyzing the conditioned signal to identify one or more candidate waveforms. Each candidate waveform meets one or more analog or digital signal characteristic criteria associated with an artificially induced neuromuscular response. The method then compares a first candidate waveform to a second candidate waveform to determine a degree of similarity between the first and second candidate waveforms, and provides an alert to a user that indicates detection of the artificially induced neuromuscular response when the degree of similarity exceeds a predetermined threshold.

An ultrasonic diagnostic imaging system produces an image of shear wave velocities by transmitting push pulses to generate shear waves. A plurality of tracking lines are transmitted and echoes received by a focusing beamformer adjacent to the location of the push pulses. The tracking lines are sampled in a time-interleaved manner. The echo data acquired along each tracking line is processed to determine the time of peak tissue displacement caused by the shear waves at points along the tracking line, and the times of peaks at adjacent tracking lines compared to compute a local shear wave velocity. The resultant map of shear wave velocity values is color-coded and displayed over an anatomical image of the region of interest.