An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical coherence tomography (OCT) system for measuring the lens displacement caused by the acoustic radiation force. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. The noninvasive measurement method also utilizes phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to distinguish between tissue stiffness, such as that attributable to disease, and effects on measured stiffness that result from external factors, such as pressure applied to the tissue. Preferably, the method is used to detect tissue stiffness and to evaluate the presence of its stiffness even if it is affected by other factors such as intraocular pressure (IOP) in the case of cornea, sclera, or the lens. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases (such as keratoconus).

A sensorized surgical tool including a fiber optic shape tracking sensor for endovascular applications and methods of making the same.

Systems and methods for electronically monitoring chest sounds and/or sensing electrical cardiac signals such as ECG signals are provided. In one embodiment, a hybrid stethdiographer has a sensing assembly with a chestpiece and a user interface. Stethdiographer also includes a conduit, a power source compartment, a pair of binaurals and a corresponding pair of earpieces. The user interface includes a record button, a mode selector and a display screen. The chestpiece includes a diaphragm and a plurality of electrical cardiac sensors.

A sensor device is described herein. The sensor device includes a multi-dimensional optical sensor and processing circuitry, wherein the multi-dimensional optical sensor generates images and the processing circuitry is configured to output data that is indicative of hemodynamics of a user based upon the images. The sensor device is non-invasive, and is able to be incorporated into wearable devices, thereby allowing for continuous output of the data that is indicative of the hemodynamics of the user.

An object information acquiring apparatus comprises a light irradiation unit configured to irradiate lights having different wavelengths respectively; an acoustic wave receiving unit configured to receive an acoustic wave by each of the lights having different wavelengths respectively, and convert into an electric signal that corresponds to each of the lights having different wavelengths; a characteristic information acquiring unit configured to acquire characteristic distribution related to each position in the object based on the electric signal; a statistics acquiring unit configured to acquire a histogram from the characteristic distribution; and an image information acquiring unit configured to acquire image information causing a display device to display the characteristic distribution in the object and the histogram.

Systems and methods for estimating the location of a wave source based upon low frequency measurements acquired using multiple receivers. In one aspect, a method for estimating an end range of a radiation beam delivered to a target is provided. The method includes controlling a radiation treatment system to deliver a radiation beam inducing at least one low frequency thermoacoustic wave inside a target, and detecting, using receivers positioned about the target, sonic signals corresponding to the at least one low frequency thermoacoustic wave. The method also includes analyzing the sonic signals to determine differences in times-of-flight associated with different receivers, and estimating an end range of the radiation beam by correlating the differences in times-of-flight. The method further includes generating a report indicative of the end range of the radiation beam.

A method for locating at least one target, in an electromagnetically absorbent environment, includes: emitting at least one electromagnetic excitation signal from a source; receiving, by an acoustic sensor, an acoustic signal from emission of the excitation signal; detecting, in the received acoustic signal, a first time of receipt of a first response to the excitation signal from an acoustic disturbance caused by electromagnetic heterogeneity of the target in the environment; estimating a first distance between the target and the acoustic sensor using the first time of receipt; detecting, in the same received acoustic signal, a second time of receipt of a second response to the excitation signal from an acoustic disturbance caused by acoustic heterogeneity of the target in the environment; estimating a second distance between the source and target using the second time of receipt; obtaining a location of the target from the first and second estimated distances.

The disclosure relates to a method and system for controlling glucose levels comprising receiving behavioral sensor measurements and analyte sensor measurements, determining a plurality of analyte profiles from continuous analyte sensor measurements; grouping the plurality of analyte profiles into clusters; assigning a selected behavioral parameter or a selected pattern of behavioral parameters to each analyte profile in a first cluster, and providing a treatment recommendation.

An electroactive photonic polymer sensing device includes an imaging component that uses photonic energy to generate a photocurrent that represents a molecular parameter, wherein the imaging component includes a photosensitive material and at least one of a laser diode and/or photodiode; and a memory component that stores a representation of the molecular parameter, wherein the memory component includes at least one of a protein, vitamin, lipid, carbon allotrope, carbon tetra fluoride. A method of sensing polymers using an electroactive photonic sensing device includes converting, using an imaging component, photonic energy into electrochemical energy to generate a photocurrent that represents a molecular parameter, wherein the imaging device includes a photosensitive material and at least one of a laser diode and/or photodiode; and storing, using a memory component, a representation of the molecular parameter, wherein the memory component includes at least one of a vitamin, lipid, carbon allotrope, carbon tetra fluoride.

A system may include a controller operably connected to a diabetic therapy delivery system. The controller may be configured to: receive therapy inputs including a therapy input indicative of a glucose measure; determine a therapy input index using the at least one therapy input including the therapy input indicative of a glucose measure; map the determined therapy input index to a graded glucose control; and set the graded glucose control based on the mapped graded glucose control for the determined therapy input index, wherein the graded glucose control includes at least one of a neuromodulation target, a neuromodulation type, or at least one neuromodulation parameter value. The diabetic therapy delivery system may be configured to deliver the therapy for graded glucose control using the graded glucose control that was set based on the mapped graded glucose control.