A co/counter propagating acousto-optic modulator is provided that creates a low-intensity focused ultrasound (FUS) wave on a laser beam in a medium such as water without any auxiliary mediators or special software/hardware. The main optical effect of the FUS is the controllable focusing of the laser beam through modification of the refractive index of the medium in a time-stable and dynamic fashion. The laser beam and the FUS wave are coaxially mixed and propagated through each other. The FUS pressure field highly amplifies the power density, highly amplifies the intensity, sharpens the diameter, and reduces the full width at half maximum (FWHM) of the laser beam. The FUS pressure field keeps the laser beam's lensing power positive, with small fluctuations, as long as the ultrasound wave is coaxially propagated with the laser beam.

An intraoral optical probe is provided that includes a distal elongate optical waveguide for interrogating dental tissue. In some example embodiments, the elongate optical waveguide has dimensions suitable for the insertion of the waveguide into an exposed root canal. According to various example embodiments, the elongate optical waveguide, when inserted into an internal region of a tooth, can direct incident optical radiation from the intraoral optical probe directly onto an inner surface, such as an internal surface of a root canal, such that status of the root canal can be interrogated directly. The intraoral optical probe may be employed to provide intraoperative feedback regarding internal dental tissue, such as interoperative feedback pertaining to the interior of the root canal during an endodontic procedure, location of secondary or lateral root canals, location of the apex or tip of the root canal system and or detection of the pulp chamber roof or floor.

Method and systems for optimizing acoustic energy transmission in implantable devices are disclosed. Transducer elements transmit acoustic locator signals towards a receiver assembly, and the receiver responds with a location signal. The location signal can reveal information related to the location of the receiver and the efficiency of the transmitted acoustic beam received by the receiver. This information enables the transmitter to target the receiver and optimize the acoustic energy transfer between the transmitter and the receiver. The energy can be used for therapeutic purposes, for example, stimulating tissue or for diagnostic purposes.

Systems and methods are directed to generating and analyzing light. Spatial light response around a human fingertip in response to electrical stimulation is associated with the status of various body organs. A system that provides a particularized response indication based on spatial light response includes a camera, an electrical signal generator, a light source, a circuit, and a computer. The signal generator stimulates emission of light from the finger when the finger is at a position relative to the camera. The light source illuminates the finger at the position. The circuit activates the light source and the camera to obtain a first image of the finger at the position, activates the signal generator and the camera to obtain a second image of the emission of light from the finger at the position, determines a direction from the first image, determines a centroid from the second image, and determines a description of the second image in accordance with the direction and the centroid. The computer receives indicia of the description and provides the particularized response indication in accordance with the description, wherein the particularized response indication describes a status of various body organs.

A system for imaging a biological sample including a tubular body having a side wall defining an interior shaped and sized for receiving the biological sample, an electromagnetic source positioned at one end of the tubular body interior for directing electromagnetic energy into the biological sample in the body interior, and an ultrasonic transducer positioned along said side wall of the body for receiving ultrasonic energy induced by the electromagnetic energy and transmitted through the biological sample.

The present disclosure provides a system with an innovative electrode designed as an RF/microwave antenna as well as methods to monitor/assess biological tissue and perform surgical procedures.

Combined transducer arrays for imaging features of tissue include a transducer array configured for transmit-receive ultrasound imaging, and a transducer array configured for receive-only thermoacoustic imaging. The transmit-receive transducer array includes a plurality of transmit-receive array elements, and the receive-only transducer array includes a plurality of receive-only array elements. The receive-only array elements are registered with and surround the transmit-receive array elements. The receive-only transducer array and transmit-receive transducer array may be housed in an ultrasound probe. The combined transducer arrays may be used in composite imaging of tissue, based on the registration of the transmit-receive array elements and the receive-only array elements. Registration of the transmit-receive array and the receive-only array may involve physical alignment or proximity of these transducer arrays, and may use data representative of known geometry and positions of elements of the two arrays in reconstructing respective images (ultrasound and thermoacoustic) in composite imaging.

A thermoacoustic imaging system is provided for use in combination with an ultrasound imaging system for imaging features of tissue, the ultrasound imaging system including an ultrasound imaging probe including a transmit-receive transducer array with a plurality of transmit-receive array elements. The thermoacoustic imaging system includes a receive-only transducer array with a plurality of receive-only array elements, registered with the plurality of transmit-receive array elements. The transmit-receive transducer array is housed in an ultrasound imaging probe, and the receive-only transducer array is housed in a thermoacoustic imaging probe. The thermoacoustic imaging probe is mechanically joined to the ultrasound imaging probe, e.g., as a sleeve fitted to the ultrasound imaging probe. A combined ultrasound transducer system including the ultrasound imaging probe and an thermoacoustic imaging probe may be used in composite imaging of tissue based upon the registration of the receive-only array elements with the transmit-receive array elements.

A method for correcting fat-induced aberrations in ultrasound imaging comprises segmenting a thermoacoustic absorption image of a region of interest into at least one fat region and at least one non-fat region, creating a speed of sound map by assigning a speed of sound to each region based on tissue type of the region, correcting aberrations in the segmented thermoacoustic absorption image using the assigned speeds of sound thereby generating a corrected thermoacoustic image, and correcting an ultrasound image of the region of interest using the corrected thermoacoustic image and the speed of sound map.

A method and system for inspecting biological tissue that has no applied coatings or treatments to improve reflectivity comprises an optical detection system with an exposed surface for inspection by an optical detection system; and a laser for exciting an ultrasonic wave within the tissue, which wave propagates within the tissue at least near the surface. The optical detection system includes: a laser to emit a pulsed detection laser beam onto the surface at a detection spot, the pulsed laser beam having a wavelength at which there is large scattering and little absorption by the tissue, and a pulse duration is chosen to correspond with ultrasonic propagation times associated with a range of depths of the scan, whereby the fluence of the detection laser is not applied unless ultrasonic information regarding a given depth is being obtained; and large tendue collection optics for collecting reflected and backscattered light from the detection spot; and a demodulator to extract information from the ultrasonic wave from the collected light.