A method of administering insulin includes receiving glucose measurements of a patient at a data processing device from a continuous glucose monitoring system. The glucose measurements are separated by a time interval. The method also includes receiving patient information at the data processing device and selecting a subcutaneous insulin treatment from a collection of subcutaneous insulin treatments. The selection is based on the glucose measurements and the patient information. The selection includes one or more of a subcutaneous standard program, a subcutaneous program without meal boluses, a meal-by-meal subcutaneous program without carbohydrate counting, a meal-by-meal subcutaneous program with carbohydrate counting, and a subcutaneous program for non-diabetic patients. The method also includes executing, using the data processing device, the selected subcutaneous insulin treatment.

In some aspects, an apparatus for a biosensor includes a sensor wire and a rigid member. The rigid member may be coupled to the sensor wire and include a contact surface. The contact surface may be sized to enable a suction head of a robotic placement device to create a vacuum seal on the contact surface for lifting the sensor wire and rigid member.

Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

A method for determining the biological age or pace of aging of an adult dog, said method comprising determining the levels of one or more biomarkers selected from the group consisting of (1) blood globulin levels, (2) blood total protein, (3) blood alkaline phosphatase, (4) blood platelet count, (5) blood mean corpuscular volume or (6) urine specific gravity, comparing the results with values obtained from healthy dogs of a known age and of a similar category (toy, small, medium, large or giant). Kits, systems and/or computer media for carrying out the method form further aspects of the invention.

A method of presenting data from a remote sensor that is monitoring a subject includes obtaining a data stream from the remote sensor, wherein the data stream includes a sensor metric, a metric identifier, dynamically updated integrity information about an accuracy of the sensor metric, and a diagnostic assessment of a health condition of the subject, and then displaying, via a display associated with the client device, the diagnostic assessment of the health condition of the subject, a metric statistic associated with the diagnostic assessment, and a recommendation as to an action to be taken by the subject.

A method for detecting a failure of at least one component of a continuous analyte monitoring system is disclosed. The continuous analyte monitoring system has a failure detection resistor and an analyte sensor having at least two measurement electrodes. A constant voltage is applied between the two measurement electrodes and a first response signal is measured. A failure detection signal that is distinguishable from the constant voltage and/or from the first response signal in frequency and/or in height is applied to the continuous monitoring system, and a second response signal to the failure detection signal is measured using the failure detection resistor. Information is determined depending on at least one actual property of the component by evaluating the first response signal and the second response signal. A failure is detected if the information deviates from an expected value by more than a predetermined tolerance.

This disclosure relates to a method of manufacturing an in vivo analyte sensing device, which is adapted for detecting at least one analyte in a body fluid or tissue and an in vivo analyte sensing device obtainable by said manufacturing method. Further, this disclosure relates to a method of manufacturing a sensor base plate and a sensor base plate obtainable by said manufacturing method. The sensor base plate may be used for the manufacture of an in vivo analyte sensing device.

Methods and systems for delaying alarms that include detecting an analyte level using an analyte sensor; and delaying the annunciation of an analyte alarm after the analyte level crosses an analyte threshold, wherein the delay is based on one or both of (1) a magnitude of difference between the analyte level and the analyte threshold and (2) a duration of time in which the analyte level has crossed the analyte threshold.

Glucose monitoring devices and related systems and methods, the glucose monitoring devices including a sensor electronics unit having a housing and a printed circuit board disposed within the housing, a transcutaneous glucose sensor assembly, and a conductive sensor connector. The printed circuit board includes a first electrical contact, the transcutaneous glucose sensor assembly includes a distal portion having a working electrode and proximal portion having a working-electrode contact in electrical communication with the working electrode, and the conductive sensor connector electrically connects the working-electrode contact with the first electrical contact. Further, the conductive sensor connector extends through a hole in the proximal portion of the transcutaneous glucose sensor assembly and through a hole in the printed circuit board.

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.