A therapy platform can leverage mood tracking to personalize delivery of therapy. User input data is collected to generate one or more mood scores that change over time. Tracked mood scores can include an overall mood score (e.g., −100 to 100 where −100 represents a strongly negative or “bad” mood and 100 represents a strongly positive or “happy” mood) and/or enumerated mood scores (e.g., numerical scores tracking individual, enumerated moods, such as “anxious,” “sad,” “tired,” “happy,” and the like). In some cases, an overall mood score can be made up of enumerated mood scores. Tracked mood scores can be used to inform the selection of what therapy to provide. For example, a first therapy tool may be selected for delivery when the user evidences a first set of mood scores, whereas a second therapy tool may be selected when the user evidences a second set of mood scores.

A healthcare apparatus includes a BCG sensor; a camera; and a processor configured: to detect a ROI) corresponding to the face from the color facial image; to convert the detected first color image into a black and white image to acquire a first black and white image; to convert the detected second color image into a black and white image to acquire a second black and white image; to apply the acquired first black and white image and the acquired second black and white image to a predetermined trained algorithm model to output a remote photoplethysmography (rPPG) signal waveform of the subject; to calculate a first stress index based on the first heart rate variability; to calculate a second stress index based on the second heart rate variability; and to output a stress index of the subject based on the first stress index and the second stress index.

A healthcare apparatus includes a BCG sensor; a camera; and a processor configured: to detect a ROI) corresponding to the face from the color facial image; to convert the detected first color image into a black and white image to acquire a first black and white image; to convert the detected second color image into a black and white image to acquire a second black and white image; to apply the acquired first black and white image and the acquired second black and white image to a predetermined trained algorithm model to output a remote photoplethysmography (rPPG) signal waveform of the subject; to calculate a first stress index based on the first heart rate variability; to calculate a second stress index based on the second heart rate variability; and to output a stress index of the subject based on the first stress index and the second stress index.

A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.

Systems and methods are disclosed for evaluating human eye tracking. One method includes receiving data representing the location of and/or information tracked by an individual's eye or eyes before, during, or after the individual performs a task; identifying a temporal phase or a biomechanical phase of the task performed by the individual; identifying a visual cue in the identified temporal phase or biomechanical phase; and scoring the tracking of the individual's eye or eyes by comparing the data to the visual cue.

The present invention relates to a device, system and method for determining an emotional state of a user based on emotion-induced cortisol estimation. The device comprises an interface (11) for obtaining a psychophysiological signal trace (22) indicative of one or more measured stimulus responses corresponding to a neural stress response; a processing unit (12) for processing the psychophysiological signal trace, wherein the processing unit is configured to determine one or more stimulus responses (29) in the psychophysiological signal trace (22); to determine a first contribution (91) to an estimated future cortisol level trace (93) based on the one or more determined stimulus responses (29) in the psychophysiological signal trace (22);to determine a second contribution (92) to the estimated future cortisol level trace (93) based on one or more anticipated future stimulus responses (96); and to determine an estimated future emotional state of the user based on said first and said second contribution to the estimated future cortisol level trace (93). The invention further relates to a corresponding computer program and a wearable device (30).

Example systems, methods, and apparatus are provided for using data collected from the responses of an individual with the computerized tasks of a cognitive platform to derive performance metrics as an indicator of cognitive abilities, and applying predictive models to generate an indication of neurodegenerative condition. The example systems, methods, and apparatus also can be configured to adapt the computerized tasks to enhance the individual's cognitive abilities, and for using data collected from the responses of an individual with the adapted computerized tasks to derive performance metrics and applying predictive models to generate the indication of neurodegenerative condition.

The computer implemented method makes it possible to discern, for a variety of sensations, whether a sensation is a pleasant (comfortable) sensation or a sensation of discomfort. A classifier is generated for discerning the stress or comfort/discomfort of a subject. The method comprising: a) imparting, to a subject, different stimuli under the same environment, and obtaining brain wave data or analysis data thereof for the environment; b) correlating a reaction of the subject relating to the stimulation and the difference of the brain wave data or analysis data thereof obtained under the environment; c) generating a classifier for discerning the stress or comfort/discomfort of the subject, on the basis of the correlation; and d) performing comfort/discomfort discernment using a basic step for amplifying a sample from a small stimulation.

Systems and methods for mapping neuronal circuitry in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a neuronal shape graph, including obtaining functional brain imaging data from an imaging device, where the functional brain imaging data includes a time-series of voxels describing neuronal activation over time in a patient's brain, lowering the dimensionality of the functional brain imaging data to a set of points, where each point represents the brain state at a particular time in the timeseries, binning the points into a plurality of bins, clustering the binned points, and generating a shape graph from the clustered points, where nodes in the shape graph represent a brain state and edges between the nodes represent transitions between brain states.

Systems and methods for mapping neuronal circuitry in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a neuronal shape graph, including obtaining functional brain imaging data from an imaging device, where the functional brain imaging data includes a time-series of voxels describing neuronal activation over time in a patient's brain, lowering the dimensionality of the functional brain imaging data to a set of points, where each point represents the brain state at a particular time in the timeseries, binning the points into a plurality of bins, clustering the binned points, and generating a shape graph from the clustered points, where nodes in the shape graph represent a brain state and edges between the nodes represent transitions between brain states.