Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.

An oxygen-sensing assembly for attachment to a urinary catheter may include a housing having a flow pathway extending between an inlet end and an outlet end thereof, an oxygen sensor in operable communication with the flow pathway of the housing, the oxygen sensor configured to detect oxygen levels of a fluid flowing through the flow pathway and a flowrate sensor configured to detect a flowrate of the fluid flowing through the flow pathway. A risk of acute kidney injury may be determined based on the mass flowrate of oxygen through the flow pathway, determined based on the detected oxygen levels and the flowrate of the fluid through the flow pathway. Related catheter assemblies and methods are also disclosed.

The present invention relates to methods and apparatuses for estimating the status of a bladder, especially with respect to the likelihood of an imminent voiding of the bladder. The apparatuses carry out computer-implemented methods of estimating a bladder status employing a bladder monitor which collects bladder data (e.g. using ultrasound) and transmits the bladder data to a data processor for algorithmic conversion to a bladder status. Such algorithms may be trained and tuned to a particular person's bladder. Having established a bladder status based on otherwise esoteric bladder data, the data processor may then trigger an alert signal where the bladder status meets particular criteria indicating an imminent voiding event. Such a trigger signal may be used to alert a nocturnal enuresis patient to an impending void so that they can be awoken before any bedwetting occurs.

A method for determining a glomerular filtration rate (GFR) in a patient includes administering to said patient a compound of Formula I and transdermally measuring spectral energy emitted by the compound of Formula I over a measurement time window. The spectral energy is emitted by the compound of Formula I in response to electromagnetic radiation delivered to the compound of Formula I. The method also includes determining the GFR in said patient based on the measured spectral energy emitted by the compound of Formula I over the measurement time window by fitting an exponential function to the spectral energy as a function of time or a linear function to the log of the spectral energy as a function of time to calculate a rate constant associated with renal clearance over the measurement time window and directly related to the GFR normalized to a body size metric of the patient.

Embodiments of the invention provide devices and systems to monitor fullness of a patient’s bladder. One embodiment of a bladder fullness (BF) measure system comprises a sensor device (SD) and a controller. The SD generates an output signal (OS) based on the force exerted by the bladder against SD the wherein the OS corresponds to a degree of BF. The SD may be attached to the bladder wall or adjoining tissue and positioned between the bladder and the pubic bone such that the SD is not affected by tissues force other than that from the bladder. The controller connects to the SD and causes an associated implant to perform a function when the SD output signal exceeds a predetermined threshold. Embodiments are particularly useful for providing information on BF to patients suffering from spinal injury or other conditions whereby they have lost the ability to sense BF and/or voluntarily urinate.

Methods and apparatuses for monitoring and regulating physiological states and functions are disclosed. Several embodiments include application of one or more microelectrode arrays to a dorsal root ganglion for measurement of sensory neuron activity, or stimulation of sensory reflex circuits. The methods and apparatuses can be used, for example, for monitoring or controlling bladder function in a patient.

This application relates to a pressure sensor array for urodynamic testing capable of simultaneously measuring bladder pressure, prostate pressure, and urethral pressure, and to a test apparatus including the pressure sensor array. In one aspect, the pressure sensor array for urodynamic testing is installed in a catheter and includes a base substrate having flexibility.

The pressure sensor array may also include a bladder pressure sensor formed on a portion of the base substrate to be positioned in bladder and measuring bladder pressure. The pressure sensor array may further include a prostate pressure sensor formed on a portion of the base substrate to be positioned in prostate and measuring prostate pressure. The pressure sensor array may further include a urethral pressure sensor formed on a portion of the base substrate to be positioned in urethra and measuring urethral pressure.

A non-invasive detection device for uric acid includes a waterproof casing, a monitor, a detection part, and a processor. The waterproof casing includes an internal space and a detection end. The monitor is mounted on the waterproof casing. The detection part includes a detection passage, a light source module, and at least one sensor. The detection passage is configured for urine to pass through. The light source module emits a detection beam with a first wavelength to the detection passage. The at least one sensor is mounted in the internal space, receives the detection beam penetrating the urine, and generates a light intensity signal according to the detection beam. The processor electrically connects to the monitor, the light source module, and the at least one sensor. The processor receives the light intensity signal, and calculates the uric acid content in the urine to generate a detection result.

A non-invasive detection device for uric acid includes a waterproof casing, a monitor, a detection part, and a processor. The waterproof casing includes an internal space and a detection end. The monitor is mounted on the waterproof casing. The detection part includes a detection passage, a light source module, and at least one sensor. The detection passage is configured for urine to pass through. The light source module emits a detection beam with a first wavelength to the detection passage. The at least one sensor is mounted in the internal space, receives the detection beam penetrating the urine, and generates a light intensity signal according to the detection beam. The processor electrically connects to the monitor, the light source module, and the at least one sensor. The processor receives the light intensity signal, and calculates the uric acid content in the urine to generate a detection result.

Improved urine output collection apparatus and monitoring device features are provided. The disposable urine collection apparatus includes a collection reservoir and a diverter for controlling the flow of urine to a first passageway of the diverter in a first position and to a second passageway of the diverter in a second position, wherein the first passageway is fluidly interconnected to the collection reservoir. The disposable urine collection apparatus may include a cartridge having an internal chamber and inlet and outlet members interconnected to the cartridge, wherein the inlet member is selectively, fluidly interconnectable to the second passageway of the diverter, and wherein the outlet member is selectively, fluidly interconnectable to the collection reservoir. The monitoring device is interconnectable with the cartridge and operable to monitor a volume and/or level of urine collected within the cartridge. The cartridge may include a front portion and a reduced-width projecting portion extending rearwardly from the front portion. The projecting portion of the cartridge may be received within a recessed portion of the monitoring device. The monitoring device may include at least light source (e.g. a laser diode) for emitting a fan beam light signal into the projecting portion and a light detector array (e.g. a charge coupled device) for detection of the fan beam light signal and output of signals employable to determine a volume and/or level of collected urine.