A method for stimulating contraction of a target muscle, the method including: locating a first neuromuscular junction of a target muscle by visualization or palpation, delivering a first stimulus to the first neuromuscular junction, locating a second neuromuscular junction of the target muscle by visualization or palpation, and delivering a second stimulus to the second neuromuscular junction. The first and second stimuli are effective to stimulate contraction of the target muscle. Further, contraction of the target muscle is effective to result in a measurable increase of at least one of: output force of the target muscle or range of motion of a body part associated with extension or contraction of the target muscle.

The present embodiments discloses a musculoskeletal assessment system having a dimensioned base unit including a plurality of sensors configured to transmit medical information corresponding to a patient. Sensors include a motion sensor, a thermographic sensor, a photographic device, and a dynamometer. Each sensor transmits medical information via an integrated computer system.

A dental imager includes an elongated handle with a rotatable head coupled to a distal end thereof and having a central platform with a plurality of arcuate scanning arms pivotally coupled thereto by a hinge. The arcuate scanning arms are of a shape and size for general deployment around a tooth and each include at least one scanner and a roller guide that comfortably rolls along the surface of the tooth or gums to bias the scanners a desired distance from the surface of the tooth, conducive for imaging thereof. In this respect, such a dental imager may be used in a process to scan and record the contours of an intraoral surface, the data of which may be used to create a digital three-dimensional surface impression printable by a 3D printer or the like.

Modified Tryptamine, Tryptamine-2-deoxy-uridine (TrpdU) and TrpdU-phosphoramidites for oligonucleotide synthesis are provided, as well as improved methods of their synthesis and oligonucleotides comprising at least one modified TrpdU nucleotide.

An apparatus for guiding a biomedical electrode is provided, which guides a biomedical electrode to be brought into close contact with a living body surface of a voluntary muscle into optimum close contact positions on the basis of positions of the voluntary muscle and a neuromuscular junction of the voluntary muscle inside the living body surface. The relative positions of the voluntary muscle and the neuromuscular junction of the voluntary muscle to the living body surface are detected from muscle action potentials detected by myoelectric detection electrodes put into close contact with a large number of positions on the living body surface. On the basis of the relative position information, a close contact position of the biomedical electrode to be brought into close contact with the living body surface of the voluntary muscle is guided to an optimum position.

A method for measuring, monitoring, controlling, evaluating and correcting proprioceptive and/or postural and/or locomotor and/or motor and/or spatial orientation abilities of a user, includes measuring and processing in order to detect an effective movement or an effective posture of the user; comparing the effective movement or the effective posture to a theoretical movement or a theoretical posture; providing biological feedback in order to allow the user to correct his effective movement or his effective posture with respect to the theoretical movement or the theoretical posture; calculating and storing a score; transmitting the score to a third party in order to allow the latter to monitor the performances of the user; and automatically or non-automatically updating a level of difficulty.

A dental imager includes an elongated handle with a rotatable head coupled to a distal end thereof and having a central platform with a plurality of arcuate scanning arms pivotally coupled thereto by a hinge. The arcuate scanning arms are of a shape and size for general deployment around a tooth and each include at least one scanner and a roller guide that comfortably rolls along the surface of the tooth or gums to bias the scanners a desired distance from the surface of the tooth, conducive for imaging thereof. In this respect, such a dental imager may be used in a process to scan and record the contours of an intraoral surface, the data of which may be used to create a digital three-dimensional surface impression printable by a 3D printer or the like.

Systems and methods for identifying alterations in a musculoskeletal system of a subject are disclosed. After detecting physical quantities representative of a state of the subject, a biomechanical model for the subject is identified and combined movements of muscles and bones as a function of said physical quantities and of said biomechanical model are determined. The combined movements are converted into a plurality of movement steps of segments and joints. Parameters representative of the alterations are computed, and the parameters are compared with predefined reference values representative of alteration thresholds in the musculoskeletal system. The alterations are identified as a function of a failed matching between the computed parameters and the predefined reference values, and the belonging of this correspondence to one or more groups of musculoskeletal pathologies as a function of said identified alteration is determined.

The disclosed system enables monitoring of user's biological indicators for signs of impairment or disease. The system obtains a permission from a user to access a biological indicator. The system obtains a history of the biological indicator associated with the user, where the biological indicator includes movement associated with the user, a voice associated with the user, or an appearance associated with the user. The system obtains a symptom indicating an undesirable state of the user, where the symptom includes a musculoskeletal affliction. The system monitors the biological indicator of user. The system detects an anomaly in the biological indicator by comparing the biological indicator with the history of the biological indicator. The system determines whether the anomaly indicates the undesirable state of the user. Upon determining that the anomaly indicates the undesirable state of the user, the system provides a notification.

A system is disclosed herein for providing a kinetic assessment and preparation of a prosthetic joint comprising one or more prosthetic components. The system comprises a prosthetic component including sensors and circuitry configured to measure load, position of load, and joint alignment. The system further includes a remote system for receiving, processing, and displaying quantitative measurements from the sensors. The kinetic assessment measures joint alignment under loading that will be similar to that of a final joint installation. The kinetic assessment can use trial or permanent prosthetic components. Furthermore, adjustments can be made to the applied load magnitude, position of load, and joint alignment by various means to fine-tune an installation. The kinetic assessment increases both performance and reliability of the installed joint by reducing error that is introduced by elements that load or modify the joint dynamics not taken into account by prior assessment methods.