Modified Tryptamine, Tryptamine-2-deoxy-uridine (TrpdU) and TrpdU-phosphoramidites for oligonucleotide syn-thesis are provided, as well as improved methods of their synthesis and oligonucleotides comprising at least one modified TrpdU nucleotide.

Using various embodiments, an autonomous robot using data captured from a living subject are disclosed. In one embodiment, an autonomous robot is described comprising a robotic skeleton designed similar to that of a human skeleton to simulate similar movements as performed by living subjects. The movements of the robotic skeleton are resultant due to control signals received by effectors present near or on the robotic skeleton. The robot can be configured to receive sensor data transmitted from a sensor apparatus that periodically gathers the sensor data from a living subject. The robot can then process the sensor data to transmit control signals to the effectors to simulate the actions performed by the living subject and perform a predictive analysis to learn the capability of generating spontaneous and adaptive actions, resulting in an autonomous robot that can adapt to its surroundings.

A tactile device for correcting biomechanical abnormalities using physical virtual reality simulations includes an outer hollow sphere, a pliable inner hollow sphere, a plurality of actuators, and a framework. The plurality of actuators physically couple the outer hollow sphere to the pliable inner hollow sphere, and are configured to reshape the pliable inner hollow sphere as the outer hollow sphere and the pliable inner hollow sphere rotate. The framework includes a plurality of powered rollers which support the outer hollow sphere and control a rotational speed and direction of the outer and inner spheres. A set of pressure sensors detect pressure applied by a user against the pliable inner hollow sphere as the user moves within. One or more processors determine a biomechanical abnormality in the user based on pressure readings from the pressure sensors. A sphere controller then modifies a physical configuration of the pliable inner hollow sphere.

Certain exemplary ultrasound probe method and/or apparatus embodiments are described, which can be used for 2D and/or 3D imaging soft tissue in an intra oral cavity.

A neuromuscular, physiological, biomechanical, or musculoskeletal activity monitoring system for a subject is provided. The system includes a wearable inertial measurement unit including at least one accelerometer and/or at least one gyroscope. The system also includes a controller in communication with an output component. The controller is configured to: receive and process information from the inertial measurement unit representative of one or more physical actions performed by the subject; generate an inertial data set for the one or more physical actions based on the received and processed information; compare the generated inertial data set to reference data stored on computer readable memory in communication with the controller; and cause the output component to provide feedback including predictive injury information. The predictive injury information is based, at least in part, on the comparison between the generated data set and the reference data.

Systems and methods are disclosed that facilitate providing guidance to a user during performance of a program or routine using a personalized avatar. In an aspect, a system includes a reception component configured to receive biochemical information about a physiological state or condition of a user, including information identifying a presence or a status of one or more biomarkers. The system further includes an analysis component configured to determine or infer one or more characteristics of the physiological state or condition of the user based on the information identifying the presence or the status of the one or more biomarkers, and a visualization component configured to adapt an appearance of an avatar presented to the user based on the one or more characteristics to reflect the one or more characteristics.

Identifying an alteration in a musculoskeletal system of a subject includes detecting physical quantities representative of a state of mind of the subject, generating a biomechanical model for the subject, determining combined movements of muscles and bones as a function of the physical quantities and the biomechanical model, converting the combined movements into movement steps of human body segments of the subject and human body joints of the subject, the movement steps being computed as a function of first joint parameters of a first joint and at least one second joint parameter computed as a function of second joints affected by the movement of the first joint, identifying the alteration based on a failed matching between parameters, determined based on the movement steps, and reference values representative of alteration thresholds in the musculoskeletal system, and determining a belonging of the alteration to group(s) of musculoskeletal pathologies.

Systems and methods are disclosed that facilitate providing guidance to a user during performance of a program or routine using a personalized avatar. In an aspect, a system includes a reception component configured to receive biochemical information about a physiological state or condition of a user, including information identifying a presence or a status of one or more biomarkers. The system further includes an analysis component configured to determine or infer one or more characteristics of the physiological state or condition of the user based on the information identifying the presence or the status of the one or more biomarkers, and a visualization component configured to adapt an appearance of an avatar presented to the user based on the one or more characteristics to reflect the one or more characteristics.

This invention relates to molecular diagnostics and, more specifically DNA-based tests for the prognosis and/or monitoring of fibrotic disease progression in humans, and processes for stratifying patients based on their likely rates of fibrotic disease progression. The invention also relates to the field of therapy for fibrotic disease, based on such prognoses, monitoring and stratification results, such as in monitoring and/or stratifying and/or treating patients having a higher likelihood of rapid fibrotic disease progression.

An apparatus for guiding a biomedical electrode is provided, which guides a biomedical electrode to be brought into close contact with a living body surface of a voluntary muscle into optimum close contact positions on the basis of positions of the voluntary muscle and a neuromuscular junction of the voluntary muscle inside the living body surface. The relative positions of the voluntary muscle and the neuromuscular junction of the voluntary muscle to the living body surface are detected from muscle action potentials detected by myoelectric detection electrodes put into close contact with a large number of positions on the living body surface. On the basis of the relative position information, a close contact position of the biomedical electrode to be brought into close contact with the living body surface of the voluntary muscle is guided to an optimum position.