Transducer probes for ophthalmological instruments operating without the use of light (such as contact tonometers and ultrasound pachymeters)—whether structured substantially monolithically (as one piece) or in a hybrid or composite fashion (and, therefore, reversibly separable into constituent components)—the axially-located front transducer surface of which is surrounded by a ridge of material not representing the surface of the transducer, in which the overall front cornea-contacting surface of which is inwardly shaped to reduce or even completely avoid measurement errors associated with the use of conventionally-structured versions of probes traditionally use with such instruments. Ophthalmological instruments utilizing such probes and methods of use. Biological protection of eye during use of such instruments.

Transducer probes for ophthalmological instruments operating without the use of light (such as contact tonometers and ultrasound pachymeters)—whether structured substantially monolithically (as one piece) or in a hybrid or composite fashion (and, therefore, reversibly separable into constituent components)—the axially-located front transducer surface of which is surrounded by a ridge of material not representing the surface of the transducer, in which the overall front cornea-contacting surface of which is inwardly shaped to reduce or even completely avoid measurement errors associated with the use of conventionally-structured versions of probes traditionally use with such instruments. Ophthalmological instruments utilizing such probes and methods of use. Biological protection of eye during use of such instruments.

What is provided are methods of analyzing at least one image of the anterior segment of an eye and for selecting an intraocular lens (IOL). The methods may include detecting at least one image from an anterior segment of the eye; identifying a location of a reference structure on the eye using a plurality of points of a landmark on the anterior segment of the eye; and calculating at least one quantitative dimension of the anterior segment of the eye using the reference structure. The newly identified landmarks and quantifiable dimensions improve the characterization of the anterior segment in order to better predict the position and movement of the intraocular lens. The improved methods for analyzing the imaging of the anterior segment of the eye allows for improvements in the refractive outcomes of cataract surgery, glaucoma procedures, refractive outcomes, and other eye-related diseases.

What is provided are methods of analyzing at least one image of the anterior segment of an eye and for selecting an intraocular lens (IOL). The methods may include detecting at least one image from an anterior segment of the eye; identifying a location of a reference structure on the eye using a plurality of points of a landmark on the anterior segment of the eye; and calculating at least one quantitative dimension of the anterior segment of the eye using the reference structure. The newly identified landmarks and quantifiable dimensions improve the characterization of the anterior segment in order to better predict the position and movement of the intraocular lens. The improved methods for analyzing the imaging of the anterior segment of the eye allows for improvements in the refractive outcomes of cataract surgery, glaucoma procedures, refractive outcomes, and other eye-related diseases.

An imaging system for cell-based therapies is provided. The imagining system includes one or more optical tags configured for insertion into a cell or biological tissue, an excitation light source configured to illuminate the one or more optical tags; a detector configured to measure optical emission of the one or more optical tags; an imaging subsystem configured to determine a three-dimensional location of each of the one or more optical tags in the cell or biological tissue; and a controller in electrical communication with the excitation light source, the detector, and the imaging subsystem. Each of the one or more optical tags has a contrasting feature and includes a fluorescent material. The contrasting feature may be defined by at least one of a refractive index, shape, color, and laser emission of each optical tag of the one or more optical tags.

A system for determining an lop of a subject includes a pressurizing device for applying pressure of varying magnitude over an external surface of an eye of the subject; a monitoring device for monitoring internal vasculature of the eye and vasculature on or around the eye; and a processing unit for correlating a first pressure or pressure range with pulsation or collapse of the internal vasculature of the eye and a second pressure or pressure range with pulsation or collapse of the vasculature on or around the eye to thereby derive the IOP of the subject.

A system for determining an lop of a subject includes a pressurizing device for applying pressure of varying magnitude over an external surface of an eye of the subject; a monitoring device for monitoring internal vasculature of the eye and vasculature on or around the eye; and a processing unit for correlating a first pressure or pressure range with pulsation or collapse of the internal vasculature of the eye and a second pressure or pressure range with pulsation or collapse of the vasculature on or around the eye to thereby derive the IOP of the subject.

An intraocular pressure measurement arrangement is disclosed for measuring pressure of an eye of a patient. The arrangement can include at least one source for producing mechanical waves of several frequencies from a distance to the eye of the patient to generate at least one surface wave to the eye, a detector for detecting at least one surface wave from a distance from the eye to extract surface wave information, and a device for determining pressure information of the eye based on the surface wave information.

An intraocular pressure measurement arrangement is disclosed for measuring pressure of an eye of a patient. The arrangement can include at least one source for producing mechanical waves of several frequencies from a distance to the eye of the patient to generate at least one surface wave to the eye, a detector for detecting at least one surface wave from a distance from the eye to extract surface wave information, and a device for determining pressure information of the eye based on the surface wave information.

An ultrasound signal processor uses an excitation generator to cause displacement of a membrane or surface while a series of ultrasound pulses are applied to the membrane or surface. Phase differences between a transmitted signal and received signal are examined to determine the movement of the membrane or surface in response to the applied excitation. An examination of the phase response of the membrane or surface provides a determination as to whether the fluid type behind the membrane or surface is one of: no fluid, serum fluid, or purulent fluid.