A tomographic imaging system receives measurements at a set of frequencies of a wavefield scattered by an internal structure of an object, recursively reconstructs an image of the internal structure of the object until a termination condition is met, and renders the reconstructed image. For a current iteration, the system adds a frequency to a previous set of frequencies used during a previous iteration to produce a current set of frequencies, such that the added frequency is higher than any frequency in the previous set of frequencies, and reconstructs a current image of the internal structure of the object that minimizes a difference between a portion of the scattered wavefield measured at the current set of frequencies and a wavefield synthetized from the current image. A previous image determined during the previous iteration initializes the reconstruction of the current image.

A tomographic imaging system receives measurements at a set of frequencies of a wavefield scattered by an internal structure of an object, recursively reconstructs an image of the internal structure of the object until a termination condition is met, and renders the reconstructed image. For a current iteration, the system adds a frequency to a previous set of frequencies used during a previous iteration to produce a current set of frequencies, such that the added frequency is higher than any frequency in the previous set of frequencies, and reconstructs a current image of the internal structure of the object that minimizes a difference between a portion of the scattered wavefield measured at the current set of frequencies and a wavefield synthetized from the current image. A previous image determined during the previous iteration initializes the reconstruction of the current image.

Ultrasound devices and methods are described, including a repeatable ultrasound transducer probe having ultrasonic transducers and corresponding circuitry. The repeatable ultrasound transducer probe may be used individually or coupled with other instances of the repeatable ultrasound transducer probe to create a desired ultrasound device. The ultrasound devices may optionally be connected to various types of external devices to provide additional processing and image rendering functionality.

Ultrasound devices and methods are described, including a repeatable ultrasound transducer probe having ultrasonic transducers and corresponding circuitry. The repeatable ultrasound transducer probe may be used individually or coupled with other instances of the repeatable ultrasound transducer probe to create a desired ultrasound device. The ultrasound devices may optionally be connected to various types of external devices to provide additional processing and image rendering functionality.

In a transcatheter treatment support technique using a combination of a guide wire equipped with a photoacoustic technique and an ultrasonic imaging device, the ultrasonic imaging device estimates a front edge position of the guide wire using a difference between arrival times of photoacoustic waves arriving at an array of elements configuring an ultrasonic probe or a change of an image of the photoacoustic generation source, which depends on a distance of the photoacoustic generation source from an imaging region, and grasps a relationship between an imaging position and the front edge position of the guide wire using the estimation result. This enables visually grasping a relationship between a region (imaging region) from which an image is able to be obtained with reflective waves from a biological body with use of the ultrasonic probe and an insertion object present outside the region, particularly, the front edge of the guide wire.

Provided are a photoacoustic image generation apparatus and an insert that can evaluate whether a plurality of materials with different absorption wavelengths are present in the vicinity of a puncture needle, without preparing a plurality of light sources. A puncture needle is at least partially inserted into a subject. An optical fiber guides light with a first wavelength. A light emitting portion emits the light guided by the optical fiber. A light absorption/conversion member absorbs the light with the first wavelength emitted from the light emitting portion and converts the light with the first wavelength into light with a second wavelength. In addition, the light absorption/conversion member generates photoacoustic waves with the conversion into the light with the second wavelength.

Provided are a photoacoustic image generation apparatus and an insert that can evaluate whether a plurality of materials with different absorption wavelengths are present in the vicinity of a puncture needle, without preparing a plurality of light sources. A puncture needle is at least partially inserted into a subject. An optical fiber guides light with a first wavelength. A light emitting portion emits the light guided by the optical fiber. A light absorption/conversion member absorbs the light with the first wavelength emitted from the light emitting portion and converts the light with the first wavelength into light with a second wavelength. In addition, the light absorption/conversion member generates photoacoustic waves with the conversion into the light with the second wavelength.

A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample using a front device which is arranged and adapted to generate aerosol, smoke or vapour from the sample. Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improved a sample classification model.

A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample using a front device which is arranged and adapted to generate aerosol, smoke or vapour from the sample. Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improved a sample classification model.

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.