A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

An ultrasonic diagnostic imaging system acquires volume image flow data sets of subvolumes of a blood vessel over at least a cardiac cycle. Image data of the subvolumes is then aligned both spatially and temporally to produce 3D images of the volume flow of the blood vessel over a heart cycle. A volume flow profile curve is produced from the acquired volume image flow data sets. The subvolumes are scanned starting with the center of the blood vessel and proceeding outward therefrom. The blood vessel center may be designated manually by a user or automatically by the ultrasound system by Doppler or other methods. Each subvolume is scanned over a heart cycle, with the systolic phase in the temporal center of the acquisition interval. The subvolumes are scanned in synchronism with the heart cycle and the estimation of a heart cycle is updated during each subvolume data acquisition interval.

Provided is a probe which transmits an ultrasonic wave to a diagnostic site and receives a reception signal which is a reflected wave. The probe includes: a plurality of transducers; a plurality of low-noise amplifying circuits respectively corresponding to the plurality of transducers; and a single differential converter which converts a control signal rising with the elapse of time to a first bias signal rising with the elapse of time and a second bias signal falling with the elapse of time to control the plurality of low-noise amplifying circuits, and the low-noise amplifying circuit includes: an attenuator which attenuates an electric signal from the transducer; a first amplifying circuit which sets the first bias signal as a bias and amplifies an output signal of the attenuator to be gradually increased with the elapse of time; a second amplifying circuit which sets the second bias signal as a bias and amplifies the output signal of the attenuator to be gradually reduced with the elapse of time; and a subtractor which subtracts an output of the first amplifying circuit and an output of the second amplifying circuit.

The present disclosure a system and method for generating a tomographic image of a subject. In some aspects, the method includes receiving an initial image acquired from a subject using the tomographic imaging system, and performing, using the initial image and a cost function model, a penalty calculation based on a spatially variant hyper-parameter. The method also includes generating an updated image using the penalty calculation, and generating a finalized image by iteratively updating the updated image until a stopping criterion is met.

The present disclosure a system and method for generating a tomographic image of a subject. In some aspects, the method includes receiving an initial image acquired from a subject using the tomographic imaging system, and performing, using the initial image and a cost function model, a penalty calculation based on a spatially variant hyper-parameter. The method also includes generating an updated image using the penalty calculation, and generating a finalized image by iteratively updating the updated image until a stopping criterion is met.

The present invention provides improved methods and systems for generating enhanced images of a volume of tissue. In an aspect, the method comprises receiving from a transducer, a plurality of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating from the acoustic signals, a first reflection rendering that characterizes sound reflection, the first reflection rendering comprising a first distribution of reflection values across a region of the volume of tissue; generating from the acoustic signals, a sound speed rendering that characterizes sound speed, the sound speed rendering comprising a distribution of sound speed values across the region; generating from the sound speed rendering, a second reflection rendering that characterizes sound reflection, the second reflection rendering comprising a second distribution of reflection values across the region; and rendering one or more combined images, based on the first reflection rendering and the second reflection rendering.

The present invention provides improved methods and systems for generating enhanced images of a volume of tissue. In an aspect, the method comprises receiving from a transducer, a plurality of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating from the acoustic signals, a first reflection rendering that characterizes sound reflection, the first reflection rendering comprising a first distribution of reflection values across a region of the volume of tissue; generating from the acoustic signals, a sound speed rendering that characterizes sound speed, the sound speed rendering comprising a distribution of sound speed values across the region; generating from the sound speed rendering, a second reflection rendering that characterizes sound reflection, the second reflection rendering comprising a second distribution of reflection values across the region; and rendering one or more combined images, based on the first reflection rendering and the second reflection rendering.

Synthetic-aperture ultrasound tomography systems and methods using scanning arrays and algorithms configured to simultaneously acquire ultrasound transmission and reflection data, and process the data for improved ultrasound tomography imaging, wherein the tomography imaging comprises total-variation regularization, or a modified total variation regularization, particularly with edge-guided or spatially variant regularization.

Synthetic-aperture ultrasound tomography systems and methods using scanning arrays and algorithms configured to simultaneously acquire ultrasound transmission and reflection data, and process the data for improved ultrasound tomography imaging, wherein the tomography imaging comprises total-variation regularization, or a modified total variation regularization, particularly with edge-guided or spatially variant regularization.

A photoacoustic measurement probe and a probe unit capable of preventing generation of artifacts in a photoacoustic measurement apparatus are obtained. In a photoacoustic measurement probe having a light emitting unit that emits measurement light toward a subject, an acoustic wave detection element that detects an acoustic wave emitted from a portion of the subject that has received the measurement light, and a housing which has a surface facing the subject at the time of use and in which the light emitting unit and the acoustic wave detection element are housed, at least one slit that is opened to the housing surface and that extends from the housing surface toward the inside of the housing is provided between the light emitting unit and the acoustic wave detection element.