A surgical instrument is disclosed to remove tissue, in particular unhealthy tissue or tissue containing cancer cells, from a body and to analyse the removed tissue. A tissue removal device is arranged at a distal end of the surgical instrument, wherein the distal part of the surgical instrument comprises a movable part, for example a bendable part, to adjust a position and/or orientation of the tissue removal device with respect to a proximal end of the surgical instrument, wherein movement of the movable part can be controlled by an operator. A discharge channel is connected to the tissue removal device for discharge of removed tissue. A tissue analysis device comprises an analysis sensor to analyse non-removed tissue in front of the tissue removal device, wherein the tissue analysis device is configured to provide a sensor signal representative for an analysed characteristic of the tissue.

An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapor from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapor and/or liquid to or towards an analyzer. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.

Devices, systems, and methods of the present disclosure are directed to efficient and accurate removal of tissue from a three-dimensional anatomic structure, such as a breast, of a patient. For example, a cup can be positioned on the patient's breast to conform the breast (e.g. via suction) to a known three-dimensional contour, and a cutting tip can be moved along the three-dimensional contour at one or more predetermined distances from at least one surface of the cup. The cutting tip can remove tissue along the three-dimensional contour to form a skin envelope. As compared to a manual process performed by a surgeon, formation of the envelope through controlled movement of the cutting tip along the three-dimensional contour can improve control over dimensions of the envelope, thus, facilitating achievement of consistent outcomes by reducing the likelihood of complications associated with an envelope that is too thick, too thin, or uneven.

A method for obtaining a probability in a 3D probability map, includes: obtaining at least one value of at least one parameter for each stop of a 3D moving window, wherein a first, second, third and fourth of the stops are partially overlapped, the first and second stops are shifted from each other by a distance equal to a first dimension of a computation voxel, the first and third stops are shifted from each other by a distance equal to a second dimension of the computation voxel, and the first and fourth stops are shifted from each other by a distance equal to a third dimension of the computation voxel; matching the at least one value to a classifier to obtain a first probability for each stop of the 3D moving window; and calculating a second probability for the computation voxel based on information associated with the first probabilities for the first through fourth stops.

Devices, systems, and methods of the present disclosure are directed to efficient and accurate removal of tissue from a three-dimensional anatomic structure, such as a breast, of a patient. For example, a cup can be positioned on the patient's breast to conform the breast (e.g. via suction) to a known three-dimensional contour, and a cutting tip can be moved along the three-dimensional contour at one or more predetermined distances from at least one surface of the cup. The cutting tip can remove tissue along the three-dimensional contour to form a skin envelope. As compared to a manual process performed by a surgeon, formation of the envelope through controlled movement of the cutting tip along the three-dimensional contour can improve control over dimensions of the envelope, thus, facilitating achievement of consistent outcomes by reducing the likelihood of complications associated with an envelope that is too thick, too thin, or uneven.

Among others, the present invention provides apparatus for interacting with a biological subject to detect circulating tumor cells therein, comprising one device for sending a signal to the biological subject and optionally receiving a response to the signal from the biological entity.

The disclosure pertains to a system for localizing an anatomical site of interest. The system comprises a grid localization system (GLS) comprising a plurality of access regions and one or more indicators configured to identify from the plurality of access regions an access region of interest for accessing the anatomical site of interest. The GLS can also comprise a depth indicator. The system can further comprise, in communication with the GLS, a processor and a computer-readable medium comprising instructions that, when executed by the processor, causes the one or more indicators to identify the access region of interest. Furthermore, the system can comprise an imaging unit. Even further, the system can comprise an automated access device that accesses the anatomical site of interest based on input from the GLS and/or the processor. Also provided are methods of accessing an anatomical site of interest using the systems disclosed herein.

The invention provides systems and methods for tissue-mounted photonics. Devices of some embodiments implement photonic sensing and actuation in flexible and/stretchable device architectures compatible with achieving long term, mechanically robust conformal integration with a range of tissue classes, including in vivo biometric sensing for internal and external tissues. Tissue-mounted photonic systems of some embodiments include colorimetric, fluorometric and/or spectroscopic photonics sensors provided in pixelated array formats on soft, elastomeric substrates to achieve spatially and/or or temporally resolved sensing of tissue and/or environmental properties, while minimize adverse physical effects to the tissue. Tissue-mounted photonic systems of some embodiments enable flexible passive or active optical sensing modalities, including sensing compatible with optical readout using a mobile electronic devices such as a mobile phone or tablet computer.

Described herein are an apparatus and method by which at least one core specimen is obtained from a patient. The specimen is optionally placed on a tray, in a holder, or in another device designed to hold the tissue specimen; images of the specimens are acquired with optical coherence tomography, optical coherence tomography image data and, optionally, data from an additional imaging or analysis method, and when analyzed with the tissue classification process yield information on one or more of: the adequacy of the specimens obtained; the likelihood that they contain abnormal or malignant tissue; the regions and/or specimens most likely to contain diagnostic tissue; the approximate dimensions, area, or volume of the abnormal tissue; and the probable type of abnormality.

A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications.