Polymeric compositions, methods, and delivery devices for inhibiting bleeding are disclosed. The method includes applying a dried material topically to a wound site, where the material may include a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood and where the material may not include an active agent such as thrombin. A spring-loaded delivery device as described herein may be used to apply the dried material.

A medical dispensing device which includes a catheter, an applicator tip at a distal end of the catheter, the catheter and the applicator tip defining a lumen having a longitudinal axis and a distal opening, a plunger in the lumen and movable along the longitudinal axis, and a plurality of elements in the lumen proximal to the distal opening and distal to the plunger, the plurality of elements stacked along the longitudinal axis for dispersement of one element at a time through the distal opening via a force applied by the plunger.

A two-part tissue thickness compensator assembly can include a first tissue thickness compensator configured to be positioned relative to an anvil of a surgical stapler, a second tissue thickness compensator configured to be positioned relative to a staple cartridge of the surgical stapler, and a hinge connecting the first tissue thickness compensator to the second tissue thickness compensator. The first and/or second tissue thickness compensators may include additional engagement features, such as a raised ridge that engages a slot in the anvil and/or the staple cartridge. In certain embodiments, the first and/or second tissue thickness compensators may include an encasement that contains a suitable biologic agent. An end effector assembly may be provided for attachment to a surgical instrument that includes, for example, a staple cartridge, an anvil, a first tissue thickness compensator positioned on the anvil, and a second tissue thickness compensator positioned on the staple cartridge.

An end effector including an anvil and a staple cartridge assembly is disclosed. The staple cartridge assembly comprises a deck having steps defined thereon for compressing tissue positioned between the anvil and the staple cartridge assembly to different pressures. The staple cartridge assembly further comprises staples having different unformed heights removably stored therein. The staples are deformed against the anvil to different formed heights.

A knot tying device including a sheath configured for placement over a surgical instrument. The sheath includes a proximal end portion and a distal end portion. The distal end portion is elastically reconfigurable between a straightened configuration and a hook shaped configuration. Position of the sheath on the surgical instrument is adjustable between an extended position in which the sheath extends beyond a distal tip of the surgical instrument and a retracted position in which the sheath is pulled back from the distal tip of the surgical instrument. The distal end portion is in the hook shaped configuration when the sheath is in the extended position and the distal end portion is in the straightened configuration when the sheath is in the retracted position.

A staple cartridge comprising a tissue thickness compensator is disclosed. The tissue thickness compensator comprises an uncompressed height, a compressed height, an outer encasement, and tubular structures aligned along the longitudinal axis. The tubular structures are configured to collapse when pressure is applied to the tissue thickness compensator by tissue during the firing motion.

An occlusion balloon device includes a shaft comprising at least one inflation lumen and an inflatable balloon, the inflatable balloon having a plurality of independently inflatable and deflatable balloon portions and being in communication with the at least one inflation lumen. A method and a system comprising the occlusion balloon device enable assessment and treatment of a perforation in a vessel of a patient.

Various surgical kits are provided including a sealing cuff configured to be positioned around a body lumen and a sealant. In one embodiment, the sealing cuff can form an enclosed loop around an anastomosis and can define an interior chamber for receiving sealant therein. The sealing cuff can ensure that sealant remains in contact with the body lumen as the sealant cures and reinforces the anastomosis. Methods for sealing an anastomosis are also provided and include delivering sealant to the sealing cuff, inserting inflatable members so that they are positioned adjacent to the anastomosis, and delivering fluid to at least one of the inflatable members to expand an inner wall of the tubular organ. In certain aspects, gas and/or liquid can be delivered to an anastomosis, such as after the sealant has solidified, in order to test the effectiveness of the seal.

A sealant injection needle assembly includes a cannula assembly and a stylet assembly. The cannula assembly has a cannula hub and a cannula having a first longitudinal sealant passage and a second longitudinal sealant passage. The first longitudinal sealant passage has a first proximal sealant port and a first distal sealant port. The second longitudinal sealant passage has a second proximal sealant port and a second distal sealant port. The stylet assembly has a stylet advance hub and a stylet configured for longitudinal movement in a lumen of the cannula. The stylet has a first stage position and a second stage position. The stylet has a first exterior circumvolving channel longitudinally spaced apart from the second exterior circumvolving channel that are separately selectively and sequentially positionable in fluid communication with both of the first distal sealant port and the second distal sealant port of the cannula.

Sealant delivery systems, sealant applicators, and injection needle assemblies are disclosed. A sealant delivery system includes a sealant applicator that has two chambers separate from one another. Each chamber includes an output port on a distal end thereof. The sealant applicator also has a quarter turn connector disposed on a distal end of the sealant applicator adjacent to the output port of each chamber. The quarter turn connector is shaped to releasably interlock with a corresponding quarter turn connector of an injection needle assembly having input ports or a corresponding quarter turn connector of a dual chamber mixing syringe having mixing ports. When the injection needle assembly or the dual chamber mixing syringe is coupled to the sealant applicator via the quarter turn connector, the input ports or the mixing ports are aligned and sealed with the output port of each chamber of the sealant applicator.