Provided are apparatuses and methods for non-invasively and continuously measuring physiological parameters of a mammal subject. The apparatus includes multiple sensor systems attached to the mammal subject, and a microcontroller unit (MCU). The sensor systems are time-synchronized and communicate with each other wirelessly and bidirectionally. Each of the sensor systems includes at least one sensor configured to detect a vital sign of the mammal subject and generate a corresponding one of the physiological parameters. The MCU is in wireless communication with the plurality of sensor systems. In operation, the MCU receives, from the sensor systems, and displays the physiological parameters of the mammal subject. The apparatus and method can be used in applications such as developing therapeutics or vaccines for a disease, or diagnosing a disease.

The present disclosure generally relates to a physiological device (100) for an animal The physiological device (100) comprises: a housing (120) comprising a channel (122) therethrough; an attachment layer (140) disposed on the housing (120) for attaching the physiological device (100) to an integument portion (50) of the animal; and a sensor unit (160) comprising a set of physiological sensors (162) for measuring physiological signals from the animal integument portion (50), the sensor unit (160) engageable with the channel (122) for axial displacement within the channel (122), wherein when the device (100) is attached to the animal integument portion (50), the sensor unit (160) is axially displaceable within the channel (122) for adjusting contact with the animal integument portion (50) for measuring the physiological signals.

An example sensor apparatus includes two inductors with a first elastomer material between and at least one capacitor coupled to the two inductors. The at least one capacitor is configured, while in use, to at least partially wrap a circumference of an object and to exhibit a change in impedance in response to a pressure-manifestation change associated with the object, the change in impedance is to cause a change in the resonant frequency of the two inductors.

Described herein are systems, devices, and methods for non-invasive pregnancy testing. The systems, devices, and methods can be used to provide pregnancy status information of a subject by detecting cardiovascular activity of a fetus in the subject. Subjects can include ruminants, ungulates, and humans.

Systems and methods are disclosed to objectively identify sub-second behavioral modules in the three-dimensional (3D) video data that represents the motion of a subject. Defining behavioral modules based upon structure in the 3D video data itself—rather than using a priori definitions for what should constitute a measurable unit of action—identifies a previously-unexplored sub-second regularity that defines a timescale upon which behavior is organized, yields important information about the components and structure of behavior, offers insight into the nature of behavioral change in the subject, and enables objective discovery of subtle alterations in patterned action. The systems and methods of the invention can be applied to drug or gene therapy classification, drug or gene therapy screening, disease study including early detection of the onset of a disease, toxicology research, side-effect study, learning and memory process study, anxiety study, and analysis in consumer behavior.

Disclosed are products and methods for monitoring Klotho protein levels and for stabilizing Klotho protein in a mammalian blood sample, especially at room temperature or without freezing, for a period of time. Methods of detecting and quantifying Klotho protein levels, particularly endogenous and/or exogenous soluble alpha Klotho protein levels, methods of diagnosing Klotho protein deficiency, and methods of increasing Klotho protein levels or production, particularly endogenous and/or exogenous soluble alpha Klotho protein level(s), expression, or production, in a mammalian subject, and products useful in performing the same, including diagnostic kits and compositions for treating Klotho protein deficiency, are disclosed. Compositions are configured or formulated to augment natural soluble alpha Klotho protein production, attenuate Klotho protein damage or degradation, and/or supplement Klotho protein levels with exogenous, recombinant protein. Treatment methods and uses include administration of the compositions to human or non-human mammalian subjects.

A method for studying the behavior of an animal in an experimental area including stimulating the animal using a stimulus device; collecting data from the animal using a data collection device; analyzing the collected data; and developing a quantitative behavioral primitive from the analyzed data. A system for studying the behavior of an animal in an experimental area including a stimulus device for stimulating the animal; a data collection device for collecting data from the animal; a device for analyzing the collected data; and a device for developing a quantitative behavioral primitive from the analyzed data. A computer implemented method, a computer system and a nontransitory computer readable storage medium related to the same. Also, a method and apparatus for automatically discovering, characterizing and classifying the behavior of an animal in an experimental area. Further, use of a depth camera and/or a touch sensitive device related to the same.

Described herein are Dirofilarial exhalant signatures and methods of detecting a Dirofilaria signature in a non-blood biological sample, such as exhalant, that can be used to detect Dirofilarial infection in a subject, such as a canine.

A motion analytics system has a therapy boot, a camera for capturing motion of the therapy boot, and an external computing device communicatively coupled to the camera and the therapy boot. The therapy boot includes a foot portion, a shank portion, and a sole portion. The shank portion is disposed adjacently above the foot portion. The sole portion is disposed under the foot portion and includes sensors configured to detect motion of a user's foot. The external computing device receives motion data from the sensors and performs a data analytics method. The method includes organizing the received data; filtering at least a portion of the organized data through a frequency-based signal processing filter to remove background noise and interference therefrom; determining analytical data associated with one or more foot factors based on the filtered data; and categorizing the determined analytical data to provide context and insight about the user's motion.

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for implementing brain emulation neural networks on user devices. One of the methods includes obtaining, by a first component of a user device, a network input; processing, by the first component of the user device, the network input using an artificial neural network to generate a network output, wherein the artificial neural network has a network architecture that has been determined according to a synaptic connectivity graph, wherein the synaptic connectivity graph represents synaptic connectivity between neurons in a brain of a biological organism; and providing the network output for use by one or more second components of the user device.