A system and method for screening cervical cancer is disclosed. The system and method enable screening of cervical cancer locally at geographical location of subjects using minimum infrastructure. The system includes a visual inspection kit, a device, and a subject connection module. The visual inspection kit may include a vital stain having a predefined concentration, a sterile accessory, and an applicator accessory. The device may include an application for data collection, storage, transmission, retrieval and analytics and the subject connection module is configured to manage interaction with subjects. The method includes screening a subject using the visual inspection kit, storing and analyzing the images using the device, and connecting with subject using the subject connection module.

Provided herein relates to methods and systems of a complex biomolecule sampling using machine learning algorithms. The methods and systems provided herein can aid in selection of previously unknown biomarkers and provide a report comprising a score or probability relating to a specified biological state. The methods and systems provided herein can aid in the rational design of particles to capture biomarkers.

An apparatus for detecting material within a sample includes a light emitting unit for directing at least one light beam through the sample. The at least one light beam has a unique signature combination associated therewith responsive to passing through the sample. A Raman spectroscopic unit receives the at least one light beam that has passed through the sample and performs a Raman spectroscopic analysis to detect a first signature associated with the sample. An infrared spectroscopic unit receives the at least one light beam that has passed through the sample and performs an infrared spectroscopic analysis to detect a second signature associated with the sample. A database includes a plurality of unique combinations of the first signature and the second signature. Each of the plurality of unique combinations of the first signature and the second signature are associated with a particular material. A processor detects the material within the sample responsive to a comparison of a unique combination of the first signature and the second signature detected by the Raman spectroscopic unit and the infrared spectroscopic unit with the plurality of unique combinations of first signature and second signature within the database and determines a matching unique combination of the first signature and the second signature within the database, wherein identification of the unique combination of the first signature and the second signature enables detection of the material not detectable using either the first signature or the second signature alone.

Disclosed are instruments and methods for acquiring co-registered orthogonal fluorescence and photoacoustic volumetric projections of an interrogated object. In an embodiment, an instrument includes a rotary mechanism configured to rotate an interrogated object relative to an array of photoacoustic transducers and an optical detector. An optical excitation unit is configured to irradiate the interrogated object with pulses of light, inducing both fluorescence and photoacoustic responses inside the interrogated object at each of a plurality of rotational positions. The array of photoacoustic transducers includes unfocused elements arranged in a pattern along an axis of rotation, the elements configured to detect photoacoustic signals generated inside the volume of the interrogated object. The optical detector is arranged opposite to the array of photoacoustic transducers with respect to the axis of rotation and is configured to register sources of fluorescence excited inside the interrogated object. Each of the optical excitation axes form with each of the optical detection axes, and with each of the photoacoustic detection axes, angles that are between 60 and 90 so as to enable acquisition of co-registered orthogonal fluorescence and photoacoustic volumetric projections of the interrogated object.

Described here is a deep brain stimulation (DBS) approach that targets several relevant nodes within brain circuitry, while monitoring multiple symptoms for efficacy. This approach to multi-symptom monitoring and stimulation therapy may be used as an extra stimulation setting in extant DBS devices, particularly those equipped for both stimulation and sensing. The therapeutic efficacy of DBS devices is extended by optimizing them for multiple symptoms (such as sleep disturbance in addition to movement disorders), thus increasing quality of life for patients.

A ceramic guide device includes a columnar ceramic guide including a first portion including a first end, a second portion including a second end and having a smaller diameter than a diameter of the first portion, and a third portion disposed between the first portion and the second portion, the columnar ceramic guide provided with an insertion hole through which a long wire electrode can be inserted from the first end to the second end; and the long wire electrode that penetrates through the insertion hole, the long wire electrode including a first protruding portion projecting from the first end, and a second protruding portion projecting from the second end.

Methods, systems, and devices are provided for assessing visual function, especially in animals. For example, a device can be used for assessing visual functions, such as PLR and OMR, in animals that includes a visual stimulus unit. The device can also include one or more input devices that include at least one camera that is configured to monitor movement of the test subject and a processor that is configured to analyze the movement of the test subject taken by the camera and to assess visual functions of the test subject. The device can be used in a system including a designated general location for the test subject in which the test subject can see the visual stimulus unit and move freely while being monitored by the camera.

Methods and systems are disclosed for remotely and/or automatically controlling a probe to measure signals.

Disclosed herein is early genetic screening to aid in the selection of dogs for assistance training programs. Disclosed methods include a method for predicting the probability of canine success in a training program, involving genotyping a biological sample from a canine; determining at least one mobile element insertion copy number within the Williams-Beuren Syndrome (WBS) locus on canine chromosome 6; and predicting the probability of the canine's success in a training program based on the at least one mobile element insertion copy number. Another disclosed method is a method of producing dogs that are more likely to exhibit a sociable behavior, involving providing a male and female dog for breeding; determining at least one mobile element insertion copy number within the Williams-Beuren Syndrome (WBS) locus on canine chromosome 6 for each of the provided dogs; and mating the dogs of step (a) to produce offspring.

Disclosed are systems and methods for detecting and quantifying chemicals in a sample using an animal having been trained to detect the chemical. A lower detection limit at which the animal can detect the chemical is determine. The animal is enclosed in a chamber, and air is introduced to the chamber in a series of tests having a different ratio of filtered air not having contacted the sample to air from the sample at increasing concentrations of the chemical until the animal detects the chemical. Then the concentration of the chemical in the sample is approximated by dividing the lower detection limit at which the non-human animal detects the chemical species by a ratio of a volume of air in contact with the sample to a total volume of air entering the chamber at which the non-human animal detects the chemical.